Platelet Glycoprotein GPIIb-IIIa Complex [trombocytový glykoproteinový komplex IIb-IIIa]

topical
93
Terms

Glycoproteins IIb-IIIa
GPIIb-IIIa Receptors
Integrin alpha-IIb beta-3
Integrin alphaIIbbeta3

Persistent link   https://www.medvik.cz/link/D019039
Definition

Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.

DUI
D019039 MeSH Browser
CUI
M0028424
Previous indexing
Platelet Membrane Glycoproteins (1987-1995); Integrins (1992-1995)
History note
1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995
Public note
1996; see PLATELET MEMBRANE GLYCOPROTEINS 1987-95; INTEGRIN ALPHAIIBBETA3 was indexed under INTEGRINS 1992-95

Combination

deficiency
Thrombasthenia

Allowable subheadings

AD
administration & dosage 8
AE
adverse effects 2
AG
agonists
AA
analogs & derivatives
AN
analysis 3
AI
antagonists & inhibitors 67
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 1
CL
classification
DE
drug effects 4
EC
economics
GE
genetics 4
HI
history
IM
immunology 3
IP
isolation & purification
ME
metabolism 4
PK
pharmacokinetics
PD
pharmacology 4
PH
physiology 4
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 22
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D09 Carbohydrates 723
D09.400 Glycoconjugates 58
D09.400.430 Glycoproteins 638
D09.400.430.890 Membrane Glycoproteins 201
D09.400.430.890.625 Platelet Membrane Glycoproteins 33
D09.400.430.890.625.136 CD36 Antigens 51
D09.400.430.890.625.298 Integrin alpha2beta1 3
D09.400.430.890.625.379 Integrin alpha5beta1 3
D09.400.430.890.625.419 Integrin alpha6beta1
D09.400.430.890.625.439 Integrin alphaVbeta3 7
D09.400.430.890.625.449 Lysosomal-Associated Membrane Protein 1 3
D09.400.430.890.625.460 Platelet Glycoprotein GPIb-IX Complex 8
D09.400.430.890.625.785 Platelet Glycoprotein GPIIb-IIIa Complex 93
D09.400.430.890.625.800 Receptors, Thrombin 14
D09.400.430.890.625.905 P-Selectin 43
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 579
D12.776.395 Glycoproteins 638
D12.776.395.550 Membrane Glycoproteins 201
D12.776.395.550.625 Platelet Membrane Glycoproteins 33
D12.776.395.550.625.136 CD36 Antigens 51
D12.776.395.550.625.298 Integrin alpha2beta1 3
D12.776.395.550.625.379 Integrin alpha5beta1 3
D12.776.395.550.625.419 Integrin alpha6beta1
D12.776.395.550.625.439 Integrin alphaVbeta3 7
D12.776.395.550.625.449 Lysosomal-Associated Membrane Protein 1 3
D12.776.395.550.625.460 Platelet Glycoprotein GPIb-IX Complex 8
D12.776.395.550.625.785 Platelet Glycoprotein GPIIb-IIIa Complex 93
D12.776.395.550.625.800 Receptors, Thrombin 14
D12.776.395.550.625.905 P-Selectin 43
D12.776.543 Membrane Proteins 850
D12.776.543.550 Membrane Glycoproteins 201
D12.776.543.550.625 Platelet Membrane Glycoproteins 33
D12.776.543.550.625.136 CD36 Antigens 51
D12.776.543.550.625.298 Integrin alpha2beta1 3
D12.776.543.550.625.379 Integrin alpha5beta1 3
D12.776.543.550.625.419 Integrin alpha6beta1
D12.776.543.550.625.439 Integrin alphaVbeta3 7
D12.776.543.550.625.449 Lysosomal-Associated Membrane Protein 1 3
D12.776.543.550.625.460 Platelet Glycoprotein GPIb-IX Complex 8
D12.776.543.550.625.785 Platelet Glycoprotein GPIIb-IIIa Complex 93
D12.776.543.550.625.800 Receptors, Thrombin 14
D12.776.543.550.625.905 P-Selectin 43
D12.776.543.750 Receptors, Cell Surface 511
D12.776.543.750.705 Receptors, Immunologic 129
D12.776.543.750.705.408 Integrins 118
D12.776.543.750.705.408.460 Receptors, Cytoadhesin 2
D12.776.543.750.705.408.460.170 Integrin alpha6beta4
D12.776.543.750.705.408.460.700 Platelet Glycoprotein GPIIb-IIIa Complex 93
D12.776.543.750.705.408.460.870 Receptors, Vitronectin 1
D12.776.543.750.705.675 Platelet Membrane Glycoproteins 33
D12.776.543.750.705.675.136 CD36 Antigens 51
D12.776.543.750.705.675.352 Integrin alpha2beta1 3
D12.776.543.750.705.675.460 Integrin alpha5beta1 3
D12.776.543.750.705.675.514 Integrin alpha6beta1
D12.776.543.750.705.675.541 Integrin alphaVbeta3 7
D12.776.543.750.705.675.554 Lysosomal-Associated Membrane Protein 1 3
D12.776.543.750.705.675.568 Platelet Glycoprotein GPIb-IX Complex 8
D12.776.543.750.705.675.784 Platelet Glycoprotein GPIIb-IIIa Complex 93
D12.776.543.750.705.675.892 Receptors, Thrombin 14

platelet glycoprotein (GP)IIIa 49-66 Chemical MeSH Browser

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