Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.

DUI

D019039 MeSH Prohlížeč

CUI

M0028424

Předchozí užití

Platelet Membrane Glycoproteins (1987-1995); Integrins (1992-1995)

Historická pozn.

1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995

Veřejná pozn.

1996; see PLATELET MEMBRANE GLYCOPROTEINS 1987-95; INTEGRIN ALPHAIIBBETA3 was indexed under INTEGRINS 1992-95