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High level of Tregs is a positive prognostic marker in patients with HPV-positive oral and oropharyngeal squamous cell carcinomas
E. Lukesova, J. Boucek, E. Rotnaglova, M. Salakova, E. Koslabova, M. Grega, T. Eckschlager, B. Rihova, B. Prochazka, J. Klozar, R. Tachezy,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
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PubMed
24864233
DOI
10.1155/2014/303929
Knihovny.cz E-resources
- MeSH
- Survival Analysis MeSH
- Biomarkers blood MeSH
- Killer Cells, Natural immunology MeSH
- Demography MeSH
- Cyclin-Dependent Kinase Inhibitor p16 metabolism MeSH
- Middle Aged MeSH
- Humans MeSH
- Oropharyngeal Neoplasms blood epidemiology immunology virology MeSH
- Papillomaviridae physiology MeSH
- Prognosis MeSH
- Proportional Hazards Models MeSH
- Regression Analysis MeSH
- T-Lymphocytes, Regulatory immunology MeSH
- Carcinoma, Squamous Cell blood epidemiology immunology virology MeSH
- Neoplasm Grading MeSH
- Age Factors MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors of viral etiology have a lower recurrence rate and better prognosis. OPSCC is linked to an alteration in the immune system. Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis. The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence. MATERIAL AND METHODS: Sixty patients with oral and oropharyngeal carcinomas were enrolled. They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA. Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry. RESULTS: Significantly better disease-specific survival (DSS) was observed in patients with HPV-positive tumors. Nodal status, tumor grade, recurrence, and CD8+/Tregs ratio were identified as factors influencing DSS. A higher level of Tregs and a lower ratio of CD8/Tregs influenced overall survival (OS) independently of HPV status and age. Patients with HPV-positive tumors and high levels of Tregs survived significantly better than patients from the other groups. CONCLUSION: Better survival is associated with HPV positivity and elevated Tregs levels. Our data suggest that HPV infection and Tregs do not influence patient prognosis in concurrence.
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- $a Lukešová, Eva $u Department of Otorhinolaryngology and Head and Neck Surgery, 1st Faculty of Medicine, Charles University in Prague, University Hospital Motol, 150 06 Prague, Czech Republic ; Department of Experimental Virology, Institute of Hematology and Blood Transfusion, 128 20 Prague, Czech Republic. $7 _AN076650
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