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The A allele of cluster of differentiation 36 (CD36) SNP 1761667 associates with decreased lipid taste perception in obese Tunisian women
I. Mrizak, O. Šerý, J. Plesnik, A. Arfa, M. Fekih, A. Bouslema, M. Zaouali, Z. Tabka, NA. Khan,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1947 do Před 1 rokem
ProQuest Central
od 2001-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2001-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2001-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2001-01-01 do Před 1 rokem
- MeSH
- alely MeSH
- antigeny CD36 genetika MeSH
- aplikace orální MeSH
- chuť genetika MeSH
- chuťová percepce genetika MeSH
- chuťové pohárky fyziologie MeSH
- dietní tuky * MeSH
- dospělí MeSH
- genotyp MeSH
- interleukin-6 krev MeSH
- jednonukleotidový polymorfismus MeSH
- kyselina olejová chemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- obezita patofyziologie MeSH
- preference v jídle MeSH
- shluková analýza MeSH
- TNF-alfa genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Tunisko MeSH
Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-α (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-α gene polymorphisms.
Department of Physiology and Functional Exploration Farhat Hached University Hospital Sousse Tunisia
Institute of Animal Physiology and Genetics Academy of Science Veveří 97 602 00Brno Czech Republic
Citace poskytuje Crossref.org
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- $a Recent studies have suggested that excessive intake of dietary fat is associated with obesity. Some obese subjects have been reported to exhibit high thresholds for the gustatory detection of lipids via lipid receptors, such as cluster of differentiation 36 (CD36). We studied lingual detection thresholds for emulsions containing oleic acid in obese Tunisian women (n 203) using a three-alternative forced choice (3-AFC) method. Genotyping of the TNF-α (rs1800629), IL-6 (rs1800795) and CD36 (rs1761667) genes was performed to associate with lipid taste perception thresholds. The CD36 genotype distribution was as follows: GG (n 42), AG (n 102) and AA (n 59). Women with the CD36 GG genotype exhibited oral detection thresholds for oleic acid that were more than three times lower than those with the CD36 AA genotype. The present study confirms a high threshold of gustatory fat detection in obese women with the CD36 AA genotype, but there is no significant association with the IL-6 and TNF-α gene polymorphisms.
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