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UBL5 is essential for pre-mRNA splicing and sister chromatid cohesion in human cells
Y. Oka, H. Varmark, K. Vitting-Seerup, P. Beli, J. Waage, A. Hakobyan, M. Mistrik, C. Choudhary, M. Rohde, S. Bekker-Jensen, N. Mailand,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 2000 do Před 1 rokem
PubMed Central
od 2000
Europe PubMed Central
od 2000 do Před 1 rokem
Open Access Digital Library
od 2000-07-01
Medline Complete (EBSCOhost)
od 2000-07-01 do Před 1 rokem
Wiley Free Content
od 2000 do Před 1 rokem
PubMed
25092792
DOI
10.15252/embr.201438679
Knihovny.cz E-zdroje
- MeSH
- adaptorové proteiny signální transdukční genetika MeSH
- chromatidy genetika MeSH
- HeLa buňky MeSH
- lidé MeSH
- ligasy genetika MeSH
- mitóza genetika MeSH
- oční proteiny genetika metabolismus MeSH
- prekurzory RNA genetika MeSH
- proteiny buněčného cyklu genetika MeSH
- regulace genové exprese MeSH
- Saccharomyces cerevisiae - proteiny genetika MeSH
- segregace chromozomů genetika MeSH
- sestřih RNA genetika MeSH
- spliceozomy genetika MeSH
- ubikvitiny genetika metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
UBL5 is an atypical ubiquitin-like protein, whose function in metazoans remains largely unexplored. We show that UBL5 is required for sister chromatid cohesion maintenance in human cells. UBL5 primarily associates with spliceosomal proteins, and UBL5 depletion decreases pre-mRNA splicing efficiency, leading to globally enhanced intron retention. Defective sister chromatid cohesion is a general consequence of dysfunctional pre-mRNA splicing, resulting from the selective downregulation of the cohesion protection factor Sororin. As the UBL5 yeast orthologue, Hub1, also promotes spliceosome functions, our results show that UBL5 plays an evolutionary conserved role in pre-mRNA splicing, the integrity of which is essential for the fidelity of chromosome segregation.
Department of Cell Death and Metabolism Danish Cancer Society Research Center Copenhagen Denmark
Institute of Molecular and Translational Medicine Palacky University Olomouc Czech Republic
Citace poskytuje Crossref.org
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