ataxin-3 [Ataxin-3]

tematický
1
Termíny

ataxin 3
protein Machado-Josephovy nemoci
protein spinocerebelární ataxie typu 3

 

Ataxin-3 Protein
ATXN3 Protein
Machado-Joseph Disease Protein
SCA3 Protein
Spinocerebellar Ataxia 3 Protein

Perzistentní odkaz   https://www.medvik.cz/link/D000067699
Definice

Deubikvitinační enzym z rodiny ataxinů. Podílí se na homeostáze proteinů, genetické transkripci, regulaci cytoskeletu a vývoji svalů. Expanze trinukleotidových repetic CAG v kódující oblasti genu Ataxin-3 je spojena se spinocerebelární ataxií typu 3 (Machado-Josephovou nemocí).

A deubiquitinating enzyme of the ATAXINS family. It functions in protein homeostasis, GENETIC TRANSCRIPTION; CYTOSKELETON regulation, and MYOGENESIS. CAG TRINUCLEOTIDE REPEAT EXPANSION in the Ataxin-3 gene coding region is associated with spinocerebellar ataxia-3 (MACHADO-JOSEPH DISEASE).

DUI
D000067699 MeSH Prohlížeč
CUI
M000600684
RN
EC 3.4.19.12
Předchozí užití
Proteins (1995-1997); Nerve Tissue Proteins (1998-2015); Nuclear Proteins (1998-2015)
Historická pozn.
2016 (1995)
Veřejná pozn.
2016; ATAXIN-3 was indexed under NERVE TISSUE PROTEINS AND NUCLEAR PROTEINS 1998-2015, and under PROTEINS 1995-1997

D Chemikálie a léčiva
D08.811 enzymy 1 547
D08.811.037 deubikvitinasy 5
D08.811.037.250 ataxin-3 1
D08.811.037.500 thiolesterasa ubikvitinu 26
D12.776 proteiny 2 575
D12.776.631.069 ataxiny 2
D12.776.631.069.500 ataxin-1 2
D12.776.631.069.750 ataxin-2
D12.776.631.069.875 ataxin-3 1
D12.776.631.069.901 ataxin-7
D12.776.631.069.950 ataxin-10
D12.776.660 jaderné proteiny 451
D12.776.660.075 ataxiny 2
D12.776.660.075.500 ataxin-1 2
D12.776.660.075.750 ataxin-2
D12.776.660.075.875 ataxin-3 1
D12.776.660.075.900 ataxin-7