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Chemistry of silybin
D. Biedermann, E. Vavříková, L. Cvak, V. Křen,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
24977260
DOI
10.1039/c3np70122k
Knihovny.cz E-resources
- MeSH
- Molecular Structure MeSH
- Silybum marianum chemistry MeSH
- Seeds chemistry MeSH
- Silymarin chemistry isolation & purification pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Silybin, a secondary metabolite isolated from the seeds of the blessed milk thistle (Silybum marianum) was discovered as the first member of a new family of natural compounds called flavonolignans in 1959. Over the years it has received the research attention of many organic chemists. This research has resulted in a number of semisynthetic derivatives prepared in an effort to modulate and better target the biological activities of silybin or to improve its physical properties, such as its solubility. A fundamental breakthrough in silybin chemistry was the determination of the absolute configurations of silybin A and silybin B, and the development of methods for their separation. This review covers articles dealing with silybin chemistry and also summarizes all the derivatives prepared.
References provided by Crossref.org
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