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T-cell receptor Vβ skewing frequently occurs in refractory cytopenia of childhood and is associated with an expansion of effector cytotoxic T cells: a prospective study by EWOG-MDS
AM. Aalbers, MM. van den Heuvel-Eibrink, I. Baumann, HB. Beverloo, GJ. Driessen, M. Dworzak, A. Fischer, G. Göhring, H. Hasle, F. Locatelli, B. De Moerloose, P. Noellke, M. Schmugge, J. Stary, A. Yoshimi, M. Zecca, CM. Zwaan, JJ. van Dongen, R....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Freely Accessible Science Journals
od 2011-01-28
PubMed Central
od 2011
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od 2011
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od 2011-01-01 do 2017-12-31
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od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01 do 2017-12-31
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2011-01-01
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od 2011-01-01
PubMed
24786393
DOI
10.1038/bcj.2014.28
Knihovny.cz E-zdroje
- MeSH
- cytotoxické T-lymfocyty imunologie MeSH
- dítě MeSH
- imunosupresivní léčba MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- myelodysplastické syndromy imunologie patologie MeSH
- pancytopenie imunologie MeSH
- předškolní dítě MeSH
- prospektivní studie MeSH
- receptory antigenů T-buněk alfa-beta imunologie MeSH
- studie případů a kontrol MeSH
- T-lymfocyty - podskupiny chemie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
Immunosuppressive therapy (IST), consisting of antithymocyte globulin and cyclosporine A, is effective in refractory cytopenia of childhood (RCC), suggesting that, similar to low-grade myelodysplastic syndromes in adult patients, T lymphocytes are involved in suppressing hematopoiesis in a subset of RCC patients. However, the potential role of a T-cell-mediated pathophysiology in RCC remains poorly explored. In a cohort of 92 RCC patients, we prospectively assessed the frequency of T-cell receptor (TCR) β-chain variable (Vβ) domain skewing in bone marrow and peripheral blood by heteroduplex PCR, and analyzed T-cell subsets in peripheral blood by flow cytometry. TCRVβ skewing was present in 40% of RCC patients. TCRVβ skewing did not correlate with bone marrow cellularity, karyotype, transfusion history, HLA-DR15 or the presence of a PNH clone. In 28 patients treated with IST, TCRVβ skewing was not clearly related with treatment response. However, TCRVβ skewing did correlate with a disturbed CD4(+)/CD8(+) T-cell ratio, a reduction in naive CD8(+) T cells, an expansion of effector CD8(+) T cells and an increase in activated CD8(+) T cells (defined as HLA-DR(+), CD57(+) or CD56(+)). These data suggest that T lymphocytes contribute to RCC pathogenesis in a proportion of patients, and provide a rationale for treatment with IST in selected patients with RCC.
Department of Hematology University Children's Hospital Zurich Switzerland
Department of Immunology Erasmus MC Erasmus University Medical Center Rotterdam The Netherlands
Department of Pathology Clinical Centre South West Böblingen Clinics Böblingen Germany
Department of Pediatric Hematology Oncology Ghent University Hospital Ghent Belgium
Department of Pediatrics Aarhus University Hospital Skejby Aarhus Denmark
Institute of Cell and Molecular Pathology Hannover Medical School Hannover Germany
Pediatric Hematology Fondazione IRCCS Policlinico San Matteo Pavia Italy
Citace poskytuje Crossref.org
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