-
Je něco špatně v tomto záznamu ?
APOE and spatial navigation in amnestic MCI: results from a computer-based test
J. Laczó, R. Andel, M. Vyhnalek, K. Vlcek, Z. Nedelska, V. Matoska, I. Gazova, I. Mokrisova, K. Sheardova, J. Hort,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
PubMed
24749727
DOI
10.1037/neu0000072
Knihovny.cz E-zdroje
- MeSH
- amnézie komplikace genetika patologie MeSH
- apolipoprotein E4 genetika MeSH
- funkční lateralita MeSH
- hipokampus patologie MeSH
- kognitivní dysfunkce komplikace genetika patologie MeSH
- lidé MeSH
- neuropsychologické testy MeSH
- počítače MeSH
- prostorová navigace fyziologie MeSH
- prostorové učení fyziologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: We investigated the association between APOE ε4 status and spatial navigation in patients with amnestic mild cognitive impairment (aMCI) and assessed the role of hippocampal volume in this association. METHOD: Participants were 74 patients with clinically confirmed aMCI (33 APOE ε4 noncarriers, 26 heterozygous, and 15 homozygous ε4 carriers). Body-centered (egocentric) and world-centered (allocentric) spatial navigation in a computerized human analogue of the Morris Water Maze was assessed. Brain MRI with subsequent automated hippocampal volumetry was included. RESULTS: Groups were similar in neuropsychological profile. Controlling for age, sex, education, and free memory recall, the APOE ε4 carriers performed more poorly on all spatial navigation subtasks (ps < .05). APOE ε4 homozygotes performed worse than heterozygotes (p = .021). Right hippocampal volume accounted for the differences in allocentric and delayed subtasks (ps > .05), but not in the egocentric subtask (p < .001). CONCLUSIONS: Using an easy-to-use, computer-based tool to assess spatial navigation, we found spatial navigation deficits to worsen in a dose-dependent manner as a function of APOE ε4 status. This was at least partially due to differences in right hippocampal volume.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15023471
- 003
- CZ-PrNML
- 005
- 20150728094135.0
- 007
- ta
- 008
- 150709s2014 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1037/neu0000072 $2 doi
- 035 __
- $a (PubMed)24749727
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Laczó, Jan $u Charles University.
- 245 10
- $a APOE and spatial navigation in amnestic MCI: results from a computer-based test / $c J. Laczó, R. Andel, M. Vyhnalek, K. Vlcek, Z. Nedelska, V. Matoska, I. Gazova, I. Mokrisova, K. Sheardova, J. Hort,
- 520 9_
- $a OBJECTIVE: We investigated the association between APOE ε4 status and spatial navigation in patients with amnestic mild cognitive impairment (aMCI) and assessed the role of hippocampal volume in this association. METHOD: Participants were 74 patients with clinically confirmed aMCI (33 APOE ε4 noncarriers, 26 heterozygous, and 15 homozygous ε4 carriers). Body-centered (egocentric) and world-centered (allocentric) spatial navigation in a computerized human analogue of the Morris Water Maze was assessed. Brain MRI with subsequent automated hippocampal volumetry was included. RESULTS: Groups were similar in neuropsychological profile. Controlling for age, sex, education, and free memory recall, the APOE ε4 carriers performed more poorly on all spatial navigation subtasks (ps < .05). APOE ε4 homozygotes performed worse than heterozygotes (p = .021). Right hippocampal volume accounted for the differences in allocentric and delayed subtasks (ps > .05), but not in the egocentric subtask (p < .001). CONCLUSIONS: Using an easy-to-use, computer-based tool to assess spatial navigation, we found spatial navigation deficits to worsen in a dose-dependent manner as a function of APOE ε4 status. This was at least partially due to differences in right hippocampal volume.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a amnézie $x komplikace $x genetika $x patologie $7 D000647
- 650 _2
- $a apolipoprotein E4 $x genetika $7 D053327
- 650 _2
- $a počítače $7 D003201
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a funkční lateralita $7 D007839
- 650 _2
- $a hipokampus $x patologie $7 D006624
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a kognitivní dysfunkce $x komplikace $x genetika $x patologie $7 D060825
- 650 _2
- $a neuropsychologické testy $7 D009483
- 650 _2
- $a prostorové učení $x fyziologie $7 D065853
- 650 _2
- $a prostorová navigace $x fyziologie $7 D065854
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Andel, Ross $u University of South Florida. $7 xx0219748
- 700 1_
- $a Vyhnalek, Martin $u Charles University.
- 700 1_
- $a Vlcek, Kamil $u International Clinical Research Center, St. Anne's University Hospital Brno.
- 700 1_
- $a Nedelska, Zuzana $u Charles University.
- 700 1_
- $a Matoska, Vaclav $u Homolka Hospital.
- 700 1_
- $a Gazova, Ivana $u Charles University.
- 700 1_
- $a Mokrisova, Ivana $u Charles University.
- 700 1_
- $a Sheardova, Katerina $u International Clinical Research Center, St. Anne's University Hospital Brno.
- 700 1_
- $a Hort, Jakub $u Charles University.
- 773 0_
- $w MED00003502 $t Neuropsychology $x 1931-1559 $g Roč. 28, č. 5 (2014), s. 676-84
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/24749727 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20150709 $b ABA008
- 991 __
- $a 20150728094220 $b ABA008
- 999 __
- $a ok $b bmc $g 1083808 $s 906464
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 28 $c 5 $d 676-84 $i 1931-1559 $m Neuropsychology $n Neuropsychology $x MED00003502
- LZP __
- $a Pubmed-20150709
