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Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
WH. Goodson, L. Lowe, DO. Carpenter, M. Gilbertson, A. Manaf Ali, A. Lopez de Cerain Salsamendi, A. Lasfar, A. Carnero, A. Azqueta, A. Amedei, AK. Charles, AR. Collins, A. Ward, AC. Salzberg, A. Colacci, AK. Olsen, A. Berg, BJ. Barclay, BP. Zhou,...
Carcinogenesis.
2015 ;
36 Suppl 1 (-) :
S254-S296.
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S., přehledy
Perzistentní odkaz
https://www.medvik.cz/link/bmc15031312
Grantová podpora
NT13663
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
Medline Complete (EBSCOhost)
od 1996-01-01 do Před 1 rokem
PubMed
26106142
DOI
10.1093/carcin/bgv039
Knihovny.cz E-zdroje
- MeSH
- karcinogeneze chemicky indukované MeSH
- karcinogeny životního prostředí škodlivé účinky MeSH
- lidé MeSH
- nádory chemicky indukované etiologie MeSH
- nebezpečné látky škodlivé účinky MeSH
- vystavení vlivu životního prostředí škodlivé účinky MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.
Analytische Milieu en Geochemie Vrije Universiteit Brussel Brussel B1050 Belgium
Baylor College of Medicine Houston TX 77030 USA
Cancer Research UK Cambridge Institute University of Cambridge Robinson Way Cambridge CB2 0RE UK
Centre De Recherche En Cancerologie De Lyon Lyon U1052 UMR5286 France
Charles University Prague 3rd Faculty of Medicine CZ 100 00 Prague 10 Czech Republic
Computer Science Department Southern Illinois University Carbondale IL 62901 USA
Department of Anatomy and Cell Biology University of Western Ontario London Ontario N6A 3K7 Canada
Department of Anatomy College of Medicine Yeungnam University Daegu 705 717 South Korea
Department of Biochemistry and Biology University of Bath Claverton Down Bath BA2 7AY UK
Department of Biochemistry and Cancer Biology Meharry Medical College Nashville TN 37208 USA
Department of Biochemistry Rush University Chicago IL 60612 USA
Department of Biology Jackson State University Jackson MS 39217 USA
Department of Biomedical Engineering and Cancer Biology Vanderbilt University Nashville TN 37235 USA
Department of Biomedical Sciences University of Cagliari 09124 Cagliari Italy
Department of Bioscience and Biotechnology Sejong University Seoul 143 747 Korea
Department of Cell Biology Pharmamar SAU Avda De los Reyes 1 28770 Colmenar Viejo Madrid Spain
Department of Experimental and Clinical Medicine University of Firenze Florence 50134 Italy
Department of Hygiene Kawasaki Medical School Matsushima Kurashiki Okayama 701 0192 Japan
Department of Life Sciences Tzu Chi University Hualien 970 Taiwan
Department of Medicine McGill University Montreal Quebec H4A 3J1 Canada
Department of Medicine Oncology and Pathology Stanford University Stanford CA 94305 USA
Department of Molecular and Cellular Biochemistry University of Kentucky Lexington KY 40508 USA
Department of Natural Science The City University of New York at Hostos Campus Bronx NY 10451 USA
Department of Nutrition University of Oslo Oslo Norway
Department of Obstetrics and Gynecology University of Melbourne Victoria 3052 Australia
Department of Pathology Kuwait University Safat 13110 Kuwait
Department of Pathology Wayne State University Detroit MI 48201 USA
Department of Pharmaceutical Sciences West Virginia University Morgantown WV 26506 USA
Department of Surgery Pathology Immunology Duke University Medical Center Durham NC 27710 USA
Department of Urology Kasr Al Ainy School of Medicine Cairo University El Manial Cairo 11559 Egypt
Department of Urology University of California Davis Sacramento CA 95817 USA
Environmental Risk and Health Unit Flemish Institute for Technological Research 2400 Mol Belgium
Faculty of Medicine University of Otago Dunedin 9054 New Zealand
Getting to Know Cancer Guelph N1G 1E4 Canada
Hacettepe University Center for Stem Cell Research and Development Ankara 06640 Turkey
Harvard Medical School Brigham and Women's Hospital Boston MA 02115 USA
INRS Institut Armand Frappier 531 Boulevard des Prairies Laval QC H7V 1B7 Canada
Institut De Recerca Hospital Vall D'Hebron Passeig Vall d'Hebron 119 129 08035 Barcelona Spain
Instituto de Alta Investigacion Universidad de Tarapaca Arica Chile
Istituto di Genetica Molecolare CNR Via Abbiategrasso 207 27100 Pavia Italy
Laboratory for Cell Genetics Vrije Universiteit Brussel 1050 Brussels Belgium
Lancaster Environment Centre Lancaster University Bailrigg Lancaster LA1 4AP UK
Lineberger Comprehensive Cancer Center University of North Carolina at Chapel Hill NC 27599 USA
Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington DC 20057 USA
Mouse Models of Cancer Therapies Group Vall d'Hebron Institute of Oncology 08035 Barcelona Spain
Mouse Models of Cancer Therapies Group Vall d'Hebron Institute of Oncology Barcelona 08010 Spain
National Institute for Environmental Studies 16 2 Onogawa Tsukuba Ibraki 3058506 Japan
Planet Biotechnologies Inc St Albert Alberta T8N 5K4 Canada
School of Biological Sciences The University of Reading Whiteknights Reading RG6 6UB England
School of Biological Sciences University of Reading Hopkins Building Reading Berkshire RG6 6UB UK
School of Biological Sciences University of Reading Reading RG6 6UB UK
School of Biotechnology Yeungnam University Gyeongbuk 712 749 South Korea
Spanish National Cancer Research Centre CNIO Melchor Fernandez Almagro 3 28029 Madrid Spain
Stanford University Department of Medicine Division of Oncology Stanford CA 94305 USA
Citace poskytuje Crossref.org
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- $a Goodson, William H $u California Pacific Medical Center Research Institute, 2100 Webster Street #401, San Francisco, CA 94115, USA, Getting to Know Cancer, Room 229A, 36 Arthur Street, Truro, Nova Scotia B2N 1X5, Canada, Lancaster Environment Centre, Lancaster University, Bailrigg, Lancaster LA1 4AP, UK, Institute for Health and the Environment, University at Albany, 5 University Pl., Rensselaer, NY 12144, USA, Getting to Know Cancer, Guelph N1G 1E4, Canada, School of Biotechnology, Faculty of Agriculture Biotechnology and Food Sciences, Sultan Zainal Abidin University, Tembila Campus, 22200 Besut, Terengganu, Malaysia, Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Navarra, Pamplona 31008, Spain, Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA, Instituto de Biomedicina de Sevilla, Consejo Superior de Investigaciones Cientificas. Hospital Universitario Virgen del Rocio, Univ. de Sevilla., Avda Manuel Siurot sn. 41013 Sevilla, Spain, Department of Experimental and Clinical Medicine, University of Firenze, Florence 50134, Italy, School of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK, Department of Nutrition, University of Oslo, Oslo, Norway, Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK, Department of Public Health Sciences, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy, Department of Chemicals and Radiation, Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo N-0403, Norway, Planet Biotechnologies Inc., St Albert, Alberta T8N 5K4, Canada, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40508, USA, Spanish National Cancer Research Centre, CNI
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- $a Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead / $c WH. Goodson, L. Lowe, DO. Carpenter, M. Gilbertson, A. Manaf Ali, A. Lopez de Cerain Salsamendi, A. Lasfar, A. Carnero, A. Azqueta, A. Amedei, AK. Charles, AR. Collins, A. Ward, AC. Salzberg, A. Colacci, AK. Olsen, A. Berg, BJ. Barclay, BP. Zhou, C. Blanco-Aparicio, CJ. Baglole, C. Dong, C. Mondello, CW. Hsu, CC. Naus, C. Yedjou, CS. Curran, DW. Laird, DC. Koch, DJ. Carlin, DW. Felsher, D. Roy, DG. Brown, E. Ratovitski, EP. Ryan, E. Corsini, E. Rojas, EY. Moon, E. Laconi, F. Marongiu, F. Al-Mulla, F. Chiaradonna, F. Darroudi, FL. Martin, FJ. Van Schooten, GS. Goldberg, G. Wagemaker, GN. Nangami, GM. Calaf, G. Williams, GT. Wolf, G. Koppen, G. Brunborg, HK. Lyerly, H. Krishnan, H. Ab Hamid, H. Yasaei, H. Sone, H. Kondoh, HK. Salem, HY. Hsu, HH. Park, I. Koturbash, IR. Miousse, AI. Scovassi, JE. Klaunig, J. Vondráček, J. Raju, J. Roman, JP. Wise, JR. Whitfield, J. Woodrick, JA. Christopher, J. Ochieng, JF. Martinez-Leal, J. Weisz, J. Kravchenko, J. Sun, KR. Prudhomme, KB. Narayanan, KA. Cohen-Solal, K. Moorwood, L. Gonzalez, L. Soucek, L. Jian, LS. D'Abronzo, LT. Lin, L. Li, L. Gulliver, LJ. McCawley, L. Memeo, L. Vermeulen, L. Leyns, L. Zhang, M. Valverde, M. Khatami, MF. Romano, M. Chapellier, MA. Williams, M. Wade, MH. Manjili, ME. Lleonart, M. Xia, MJ. Gonzalez, MV. Karamouzis, M. Kirsch-Volders, M. Vaccari, NB. Kuemmerle, N. Singh, N. Cruickshanks, N. Kleinstreuer, N. van Larebeke, N. Ahmed, O. Ogunkua, PK. Krishnakumar, P. Vadgama, PA. Marignani, PM. Ghosh, P. Ostrosky-Wegman, PA. Thompson, P. Dent, P. Heneberg, P. Darbre, P. Sing Leung, P. Nangia-Makker, QS. Cheng, RB. Robey, R. Al-Temaimi, R. Roy, R. Andrade-Vieira, RK. Sinha, R. Mehta, R. Vento, R. Di Fiore, R. Ponce-Cusi, R. Dornetshuber-Fleiss, R. Nahta, RC. Castellino, R. Palorini, R. Abd Hamid, SA. Langie, SE. Eltom, SA. Brooks, S. Ryeom, SS. Wise, SN. Bay, SA. Harris, S. Papagerakis, S. Romano, S. Pavanello, S. Eriksson, S. Forte, SC. Casey, S. Luanpitpong, TJ. Lee, T. Otsuki, T. Chen, T. Massfelder, T. Sanderson, T. Guarnieri, T. Hultman, V. Dormoy, V. Odero-Marah, V. Sabbisetti, V. Maguer-Satta, WK. Rathmell, W. Engström, WK. Decker, WH. Bisson, Y. Rojanasakul, Y. Luqmani, Z. Chen, Z. Hu,
- 520 9_
- $a Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.
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- 700 1_
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- 700 1_
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- 700 1_
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- $a Moorwood, Kim $u Department of Biochemistry and Biology, University of Bath, Claverton Down, Bath BA2 7AY, UK.
- 700 1_
- $a Gonzalez, Laetitia $u Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
- 700 1_
- $a Soucek, Laura $u Mouse Models of Cancer Therapies Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain, Catalan Institution for Research and Advanced Studies (ICREA), Barcelona 08010, Spain.
- 700 1_
- $a Jian, Le $u School of Public Health, Curtin University, Bentley, WA 6102, Australia, Department of Urology, University of California Davis, Sacramento, CA 95817, USA.
- 700 1_
- $a D'Abronzo, Leandro S $u Department of Urology, University of California Davis, Sacramento, CA 95817, USA.
- 700 1_
- $a Lin, Liang-Tzung $u Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
- 700 1_
- $a Li, Lin $u School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.
- 700 1_
- $a Gulliver, Linda $u Faculty of Medicine, University of Otago, Dunedin 9054, New Zealand.
- 700 1_
- $a McCawley, Lisa J $u Department of Biomedical Engineering and Cancer Biology, Vanderbilt University, Nashville, TN 37235, USA.
- 700 1_
- $a Memeo, Lorenzo $u Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.
- 700 1_
- $a Vermeulen, Louis $u Center for Experimental Molecular Medicine, Academic Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands.
- 700 1_
- $a Leyns, Luc $u Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
- 700 1_
- $a Zhang, Luoping $u Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720-7360, USA.
- 700 1_
- $a Valverde, Mahara $u Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.
- 700 1_
- $a Khatami, Mahin $u Inflammation and Cancer Research, National Cancer Institute (NCI) (Retired), National Institutes of Health, Bethesda, MD 20892, USA.
- 700 1_
- $a Romano, Maria Fiammetta $u Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
- 700 1_
- $a Chapellier, Marion $u Centre De Recherche En Cancerologie, De Lyon, Lyon, U1052-UMR5286, France.
- 700 1_
- $a Williams, Marc A $u United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.
- 700 1_
- $a Wade, Mark $u Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, Via Adamello 16, 20139 Milano, Italy.
- 700 1_
- $a Manjili, Masoud H $u Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA 23298, USA.
- 700 1_
- $a Lleonart, Matilde E $u Institut De Recerca Hospital Vall D'Hebron, Passeig Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
- 700 1_
- $a Xia, Menghang $u Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Bethesda, MD 20892-3375, USA.
- 700 1_
- $a Gonzalez, Michael J $u University of Puerto Rico, Medical Sciences Campus, School of Public Health, Nutrition Program, San Juan 00921, Puerto Rico.
- 700 1_
- $a Karamouzis, Michalis V $u Department of Biological Chemistry, Medical School, University of Athens, Institute of Molecular Medicine and Biomedical Research, 10676 Athens, Greece.
- 700 1_
- $a Kirsch-Volders, Micheline $u Laboratory for Cell Genetics, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
- 700 1_
- $a Vaccari, Monica $u Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, 40126 Bologna, Italy.
- 700 1_
- $a Kuemmerle, Nancy B $u Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
- 700 1_
- $a Singh, Neetu $u Advanced Molecular Science Research Centre (Centre for Advanced Research), King George's Medical University, Lucknow, Uttar Pradesh 226 003, India.
- 700 1_
- $a Cruickshanks, Nichola $u Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
- 700 1_
- $a Kleinstreuer, Nicole $u Integrated Laboratory Systems Inc., in support of the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, RTP, NC 27709, USA.
- 700 1_
- $a van Larebeke, Nik $u Analytische, Milieu en Geochemie, Vrije Universiteit Brussel, Brussel B1050, Belgium.
- 700 1_
- $a Ahmed, Nuzhat $u Department of Obstetrics and Gynecology, University of Melbourne, Victoria 3052, Australia.
- 700 1_
- $a Ogunkua, Olugbemiga $u Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
- 700 1_
- $a Krishnakumar, P K $u Center for Environment and Water, Research Institute, King Fahd University of Petroleum and Minerals, Dhahran 3126, Saudi Arabia .
- 700 1_
- $a Vadgama, Pankaj $u School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
- 700 1_
- $a Marignani, Paola A $u Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
- 700 1_
- $a Ghosh, Paramita M $u Department of Urology, University of California Davis, Sacramento, CA 95817, USA.
- 700 1_
- $a Ostrosky-Wegman, Patricia $u Department of Genomic Medicine and Environmental Toxicology, Institute for Biomedical Research, National Autonomous University of Mexico, Mexico City 04510, México.
- 700 1_
- $a Thompson, Patricia A $u Department of Pathology, Stony Brook School of Medicine, Stony Brook University, The State University of New York, Stony Brook, NY 11794-8691, USA.
- 700 1_
- $a Dent, Paul $u Departments of Neurosurgery and Biochemistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
- 700 1_
- $a Heneberg, Petr $u Charles University in Prague, Third Faculty of Medicine, CZ-100 00 Prague 10, Czech Republic.
- 700 1_
- $a Darbre, Philippa $u School of Biological Sciences, The University of Reading, Whiteknights, Reading RG6 6UB, England.
- 700 1_
- $a Sing Leung, Po $u School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, The People's Republic of China.
- 700 1_
- $a Nangia-Makker, Pratima $u Department of Pathology, Wayne State University, Detroit, MI 48201, USA.
- 700 1_
- $a Cheng, Qiang Shawn $u Computer Science Department, Southern Illinois University, Carbondale, IL 62901, USA.
- 700 1_
- $a Robey, R Brooks $u White River Junction Veterans Affairs Medical Center, White River Junction, VT 05009, USA, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
- 700 1_
- $a Al-Temaimi, Rabeah $u Human Genetics Unit, Department of Pathology, Faculty of Medicine, Kuwait University, Jabriya 13110, Kuwait.
- 700 1_
- $a Roy, Rabindra $u Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA.
- 700 1_
- $a Andrade-Vieira, Rafaela $u Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
- 700 1_
- $a Sinha, Ranjeet K $u Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA.
- 700 1_
- $a Mehta, Rekha $u Regulatory Toxicology Research Division, Bureau of Chemical Safety, Food Directorate, Health Canada, Ottawa, Ontario K1A 0K9, Canada.
- 700 1_
- $a Vento, Renza $u Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy , Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA 19122, USA.
- 700 1_
- $a Di Fiore, Riccardo $u Department of Biological, Chemical, and Pharmaceutical Sciences and Technologies, Polyclinic Plexus, University of Palermo, Palermo 90127, Italy .
- 700 1_
- $a Ponce-Cusi, Richard $u Instituto de Alta Investigacion, Universidad de Tarapaca, Arica, Chile.
- 700 1_
- $a Dornetshuber-Fleiss, Rita $u Department of Pharmacology and Toxicology, University of Vienna, Vienna A-1090, Austria, Institute of Cancer Research, Department of Medicine, Medical University of Vienna, Wien 1090, Austria.
- 700 1_
- $a Nahta, Rita $u Departments of Pharmacology and Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA 30322, USA.
- 700 1_
- $a Castellino, Robert C $u Division of Hematology and Oncology, Department of Pediatrics, Children's Healthcare of Atlanta, GA 30322, USA, Department of Pediatrics, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA.
- 700 1_
- $a Palorini, Roberta $u Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy, SYSBIO Centre of Systems Biology, Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
- 700 1_
- $a Abd Hamid, Roslida $u Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 43400 Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
- 700 1_
- $a Langie, Sabine A S $u Environmental Risk and Health Unit, Flemish Institute for Technological Research, 2400 Mol, Belgium.
- 700 1_
- $a Eltom, Sakina E $u Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
- 700 1_
- $a Brooks, Samira A $u Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.
- 700 1_
- $a Ryeom, Sandra $u Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
- 700 1_
- $a Wise, Sandra S $u Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, USA.
- 700 1_
- $a Bay, Sarah N $u Program in Genetics and Molecular Biology, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.
- 700 1_
- $a Harris, Shelley A $u Population Health and Prevention, Research, Prevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, M5G 2L7, Canada, Departments of Epidemiology and Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, M5T 3M7, Canada .
- 700 1_
- $a Papagerakis, Silvana $u Department of Otolaryngology - Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
- 700 1_
- $a Romano, Simona $u Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
- 700 1_
- $a Pavanello, Sofia $u Department of Cardiac, Thoracic and Vascular Sciences, Unit of Occupational Medicine, University of Padova, Padova 35128, Italy.
- 700 1_
- $a Eriksson, Staffan $u Department of Anatomy, Physiology and Biochemistry, The Swedish University of Agricultural Sciences, PO Box 7011, VHC, Almas Allé 4, SE-756 51, Uppsala, Sweden.
- 700 1_
- $a Forte, Stefano $u Department of Experimental Oncology, Mediterranean Institute of Oncology, Via Penninazzo 7, Viagrande (CT) 95029, Italy.
- 700 1_
- $a Casey, Stephanie C $u Stanford University Department of Medicine, Division of Oncology, Stanford, CA 94305, USA.
- 700 1_
- $a Luanpitpong, Sudjit $u Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
- 700 1_
- $a Lee, Tae-Jin $u Department of Anatomy, College of Medicine, Yeungnam University, Daegu 705-717, South Korea.
- 700 1_
- $a Otsuki, Takemi $u Department of Hygiene, Kawasaki Medical School, Matsushima Kurashiki, Okayama 701-0192, Japan.
- 700 1_
- $a Chen, Tao $u Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.
- 700 1_
- $a Massfelder, Thierry $u INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France.
- 700 1_
- $a Sanderson, Thomas $u INRS-Institut Armand-Frappier, 531 Boulevard des Prairies, Laval, QC H7V 1B7, Canada.
- 700 1_
- $a Guarnieri, Tiziana $u Department of Biology, Geology and Environmental Sciences, Alma Mater Studiorum Università di Bologna, Via Francesco Selmi, 3, 40126 Bologna, Italy, Center for Applied Biomedical Research, S. Orsola-Malpighi University Hospital, Via Massarenti, 9, 40126 Bologna, Italy, National Institute of Biostructures and Biosystems, Viale Medaglie d' Oro, 305, 00136 Roma, Italy.
- 700 1_
- $a Hultman, Tove $u Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala, Sweden.
- 700 1_
- $a Dormoy, Valérian $u INSERM U1113, team 3 'Cell Signalling and Communication in Kidney and Prostate Cancer', University of Strasbourg, Faculté de Médecine, 67085 Strasbourg, France, Department of Cell and Developmental Biology, University of California, Irvine, CA 92697, USA.
- 700 1_
- $a Odero-Marah, Valerie $u Department of Biology/Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.
- 700 1_
- $a Sabbisetti, Venkata $u Harvard Medical School/Brigham and Women's Hospital, Boston, MA 02115, USA.
- 700 1_
- $a Maguer-Satta, Veronique $u United States Army Institute of Public Health, Toxicology Portfolio-Health Effects Research Program, Aberdeen Proving Ground, Edgewood, MD 21010-5403, USA.
- 700 1_
- $a Rathmell, W Kimryn $u Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.
- 700 1_
- $a Engström, Wilhelm $u Department of Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, PO Box 7028, 75007 Uppsala, Sweden.
- 700 1_
- $a Decker, William K $u Baylor College of Medicine, Houston, TX 77030, USA.
- 700 1_
- $a Bisson, William H $u Environmental and Molecular Toxicology, Environmental Health Science Center, Oregon State University, Corvallis, OR 97331, USA.
- 700 1_
- $a Rojanasakul, Yon $u Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA.
- 700 1_
- $a Luqmani, Yunus $u Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, PO Box 24923, Safat 13110, Kuwait and.
- 700 1_
- $a Chen, Zhenbang $u Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA.
- 700 1_
- $a Hu, Zhiwei $u Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.
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