• Je něco špatně v tomto záznamu ?

MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study

AI. Tsonis, P. Zisimopoulou, K. Lazaridis, J. Tzartos, E. Matsigkou, V. Zouvelou, R. Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M....

. 2015 ; 284 (-) : 10-7. [pub] 20150427

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15031337

Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15031337
003      
CZ-PrNML
005      
20151013122729.0
007      
ta
008      
151005s2015 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.jneuroim.2015.04.015 $2 doi
035    __
$a (PubMed)26025053
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Tsonis, A I $u Hellenic Pasteur Institute, Athens, Greece; University of Patras, Patras, Greece.
245    10
$a MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study / $c AI. Tsonis, P. Zisimopoulou, K. Lazaridis, J. Tzartos, E. Matsigkou, V. Zouvelou, R. Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M. De Baets, M. Losen, P. Martinez-Martinez, KA. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen, A. Maniaol, C. Casasnovas Pons, J. Pitha, M. Jakubíkova, F. Hanisch, SJ. Tzartos,
520    9_
$a Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a autoprotilátky $x krev $7 D001323
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a průtoková cytometrie $7 D005434
650    _2
$a lidé $7 D006801
650    _2
$a mezinárodní spolupráce $7 D007391
650    _2
$a proteiny související s LDL-receptory $x imunologie $7 D026502
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a myasthenia gravis $x krev $x diagnóza $x patologie $7 D009157
650    _2
$a neuromyelitis optica $x diagnóza $7 D009471
650    _2
$a radioimunoanalýza $7 D011863
650    _2
$a tyrosinkinasové receptory $x imunologie $7 D020794
650    _2
$a receptory cholinergní $x imunologie $7 D011950
650    _2
$a thymus $x patologie $7 D013950
650    _2
$a hyperplazie thymu $x diagnóza $7 D013952
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Zisimopoulou, P $u Hellenic Pasteur Institute, Athens, Greece. Electronic address: zisimopoulou@pasteur.gr.
700    1_
$a Lazaridis, K $u Hellenic Pasteur Institute, Athens, Greece.
700    1_
$a Tzartos, J $u Hellenic Pasteur Institute, Athens, Greece.
700    1_
$a Matsigkou, E $u Hellenic Pasteur Institute, Athens, Greece.
700    1_
$a Zouvelou, V $u Neurology Department, Aeginition Hospital, Athens, Greece.
700    1_
$a Mantegazza, R $u Neurological Institute "C. Besta", Milano, Italy.
700    1_
$a Antozzi, C $u Neurological Institute "C. Besta", Milano, Italy. $7 gn_A_00007581
700    1_
$a Andreetta, F $u Neurological Institute "C. Besta", Milano, Italy. $7 gn_A_00006435
700    1_
$a Evoli, A $u Institute of Neurology, Catholic University, Rome, Italy.
700    1_
$a Deymeer, F $u Istanbul University, Istanbul, Turkey.
700    1_
$a Saruhan-Direskeneli, G $u Istanbul University, Istanbul, Turkey.
700    1_
$a Durmus, H $u Istanbul University, Istanbul, Turkey.
700    1_
$a Brenner, T $u Hadassah Hebrew University Medical Center, Jerusalem, Israel.
700    1_
$a Vaknin, A $u Hadassah Hebrew University Medical Center, Jerusalem, Israel.
700    1_
$a Berrih-Aknin, S $u UPMC and INSERM, Paris, France.
700    1_
$a Behin, A $u UPMC and INSERM, Paris, France.
700    1_
$a Sharshar, T $u Raymond Poincaré Hospital, Garches, France.
700    1_
$a De Baets, M $u School for Mental Health and Neuroscience, Maastricht University, The Netherlands.
700    1_
$a Losen, M $u School for Mental Health and Neuroscience, Maastricht University, The Netherlands.
700    1_
$a Martinez-Martinez, P $u School for Mental Health and Neuroscience, Maastricht University, The Netherlands.
700    1_
$a Kleopa, K A $u The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
700    1_
$a Zamba-Papanicolaou, E $u The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
700    1_
$a Kyriakides, T $u The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus.
700    1_
$a Kostera-Pruszczyk, A $u Department of Neurology, Medical University of Warsaw, Poland.
700    1_
$a Szczudlik, P $u Department of Neurology, Medical University of Warsaw, Poland.
700    1_
$a Szyluk, B $u Department of Neurology, Medical University of Warsaw, Poland.
700    1_
$a Lavrnic, D $u Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
700    1_
$a Basta, I $u Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
700    1_
$a Peric, S $u Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
700    1_
$a Tallaksen, C $u Norway Department of Neurology, Ullevaal University Hospital, Oslo, Norway; Faculty of Medicine, Olso University, Norway.
700    1_
$a Maniaol, A $u Norway Department of Neurology, Ullevaal University Hospital, Oslo, Norway.
700    1_
$a Casasnovas Pons, C $u Bellvitge University Hospital, Barcelona, Spain.
700    1_
$a Pitha, J $u Department of Neurology and Clinical Neuroscience Center, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic.
700    1_
$a Jakubíkova, M $u Department of Neurology and Clinical Neuroscience Center, 1st Faculty of Medicine, Charles University and General Teaching Hospital, Prague, Czech Republic.
700    1_
$a Hanisch, F $u Universitätsklinikum Halle, Germany.
700    1_
$a Tzartos, S J $u Hellenic Pasteur Institute, Athens, Greece; University of Patras, Patras, Greece; Tzartos NeuroDiagnostics, Athens, Greece. Electronic address: tzartos@pasteur.gr.
773    0_
$w MED00002834 $t Journal of neuroimmunology $x 1872-8421 $g Roč. 284, č. - (2015), s. 10-7
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26025053 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20151005 $b ABA008
991    __
$a 20151013122918 $b ABA008
999    __
$a ok $b bmc $g 1092213 $s 914463
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 284 $c - $d 10-7 $e 20150427 $i 1872-8421 $m Journal of neuroimmunology $n J Neuroimmunol $x MED00002834
LZP    __
$a Pubmed-20151005

Najít záznam

Citační ukazatele

    Možnosti archivace