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Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups
KW. Pajtler, H. Witt, M. Sill, DT. Jones, V. Hovestadt, F. Kratochwil, K. Wani, R. Tatevossian, C. Punchihewa, P. Johann, J. Reimand, HJ. Warnatz, M. Ryzhova, S. Mack, V. Ramaswamy, D. Capper, L. Schweizer, L. Sieber, A. Wittmann, Z. Huang, P....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
NLK
Cell Press Free Archives
od 2002-02-01 do Před 1 rokem
Free Medical Journals
od 2002 do Před 1 rokem
- MeSH
- adaptorové proteiny signální transdukční genetika MeSH
- dítě MeSH
- dospělí MeSH
- ependymom klasifikace genetika patologie MeSH
- fosfoproteiny genetika MeSH
- fúze genů MeSH
- genetická transkripce MeSH
- genová dávka MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- metylace DNA MeSH
- mladiství MeSH
- mladý dospělý MeSH
- nádory centrálního nervového systému klasifikace genetika patologie MeSH
- předškolní dítě MeSH
- senioři MeSH
- stanovení celkové genové exprese MeSH
- věkové faktory * MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.
Clinical Cooperation Unit Neuropathology German Cancer Research Center 69120 Heidelberg Germany
Clinical Cooperation Unit Pediatric Oncology German Cancer Research Center 69120 Heidelberg Germany
Department of Developmental Neurobiology St Jude Children's Research Hospital Memphis TN 38105 USA
Department of Family Health University of Texas Health Science Center SON Houston TX 77030 USA
Department of Neurological Surgery University of California San Francisco San Francisco CA 94143 USA
Department of Neuropathology NN Burdenko Neurosurgical Institute 125047 Moscow Russia
Department of Neuropathology University of Bonn 53127 Bonn Germany
Department of Neuropathology University of Heidelberg 69120 Heidelberg Germany
Department of Oncogenomics Academic Medical Center 1105AZ Amsterdam the Netherlands
Department of Pathology NYU Langone Medical Center New York NY 10016 USA
Department of Pathology St Jude Children's Research Hospital Memphis TN 38105 USA
Department of Pathology University of Bern 3010 Bern Switzerland
Department of Pathology University of Cambridge Cambridge CB2 1TN UK
Department of Pediatrics University of Colorado Denver Aurora CO 80045 USA
Department of Vertebrate Genomics Max Planck Institute for Molecular Genetics 14195 Berlin Germany
Departments of Pediatrics and Neurology NYU Langone Medical Center New York NY 10016 USA
Division of Biostatistics German Cancer Research Center 69120 Heidelberg Germany
Division of Hematology Oncology Hospital for Sick Children Toronto ON M5G 1X8 Canada
Division of Molecular Genetics German Cancer Research Center 69120 Heidelberg Germany
Division of Pediatric Neurooncology German Cancer Research Center 69120 Heidelberg Germany
German Cancer Consortium 69120 Heidelberg Germany
Institute for Neuropathology University Hospital Münster 48149 Münster Germany
Laboratory Medicine and Pathobiology University of Toronto Toronto ON M5G 1L7 Canada
Pediatric Hematology Oncology Schneider Children's Medical Center of Israel 49202 Petah Tikva Israel
The Donnelly Center University of Toronto Toronto ON M5S 3E1 Canada
Citace poskytuje Crossref.org
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