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Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN
S. Hafez Ghoran, S. Saeidnia, E. Babaei, F. Kiuchi, M. Dusek, V. Eigner, A. Dehno Khalaji, A. Soltani, P. Ebrahimi, H. Mighani,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Flavonoids chemistry isolation & purification pharmacology MeSH
- Antineoplastic Agents, Phytogenic chemistry isolation & purification pharmacology MeSH
- Crystallography, X-Ray MeSH
- Humans MeSH
- Models, Molecular MeSH
- Cell Line, Tumor MeSH
- Neoplasms drug therapy MeSH
- Plant Extracts chemistry MeSH
- Scilla chemistry MeSH
- Cell Survival drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3',4'-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a=11.7676 (2)Å, b=20.1174 (4)Å, c=7.8645 (9)Å, β=93.544 (2)°, V=1858.23 (7)Å(3), monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
Department of Animal Biology School of Natural Sciences University of Tabriz Tabriz Iran
Department of Chemistry Faculty of Sciences Golestan University Gorgan 4913815759 Iran
Department of Chemistry Gorgan Branch Islamic Azad University Gorgan Iran
Department of Pharmaceutical Sciences Faculty of Pharmacy Keio University Tokyo Japan
Institute of Physics AS CR v v i Na Slovance 2 182 21 Prague 8 Czech Republic
References provided by Crossref.org
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- $a Hafez Ghoran, Salar $u Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran; Department of Chemistry, Faculty of Sciences, Golestan University, Gorgan 4913815759, Iran. Electronic address: S.Hafezghoran@gu.ac.ir.
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- $a In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3',4'-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a=11.7676 (2)Å, b=20.1174 (4)Å, c=7.8645 (9)Å, β=93.544 (2)°, V=1858.23 (7)Å(3), monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
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