-
Je něco špatně v tomto záznamu ?
A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease
MV. Holmes, R. Frikke-Schmidt, D. Melis, R. Luben, FW. Asselbergs, JM. Boer, J. Cooper, J. Palmen, P. Horvat, J. Engmann, KW. Li, NC. Onland-Moret, MH. Hofker, M. Kumari, BJ. Keating, JA. Hubacek, V. Adamkova, R. Kubinova, M. Bobak, KT. Khaw, BG....
Jazyk angličtina Země Irsko
Typ dokumentu časopisecké články, metaanalýza, Research Support, N.I.H., Extramural, práce podpořená grantem, přehledy
- MeSH
- alely MeSH
- apolipoprotein E4 genetika MeSH
- dospělí MeSH
- genotyp * MeSH
- heterozygot MeSH
- interakce genů a prostředí MeSH
- kohortové studie MeSH
- koronární nemoc genetika MeSH
- kouření škodlivé účinky MeSH
- lidé středního věku MeSH
- lidé MeSH
- rizikové faktory MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
BACKGROUND: Conflicting evidence exists on whether smoking acts as an effect modifier of the association between APOE genotype and risk of coronary heart disease (CHD). METHODS AND RESULTS: We searched PubMed and EMBASE to June 11, 2013 for published studies reporting APOE genotype, smoking status and CHD events and added unpublished data from population cohorts. We tested for presence of effect modification by smoking status in the relationship between APOE genotype and risk of CHD using likelihood ratio test. In total 13 studies (including unpublished data from eight cohorts) with 10,134 CHD events in 130,004 individuals of European descent were identified. The odds ratio (OR) for CHD risk from APOE genotype (ε4 carriers versus non-carriers) was 1.06 (95% confidence interval (CI): 1.01, 1.12) and for smoking (present vs. past/never smokers) was OR 2.05 (95%CI: 1.95, 2.14). When the association between APOE genotype and CHD was stratified by smoking status, compared to non-ε4 carriers, ε4 carriers had an OR of 1.11 (95%CI: 1.02, 1.21) in 28,789 present smokers and an OR of 1.04 (95%CI 0.98, 1.10) in 101,215 previous/never smokers, with no evidence of effect modification (P-value for heterogeneity = 0.19). Analysis of pack years in individual participant data of >60,000 with adjustment for cardiovascular traits also failed to identify evidence of effect modification. CONCLUSIONS: In the largest analysis to date, we identified no evidence for effect modification by smoking status in the association between APOE genotype and risk of CHD.
Department of Cardiology Division Heart and Lungs University Medical Center Utrecht The Netherlands
Department of Clinical Biochemistry Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Department of Epidemiology and Public Health University College London London UK
Department of Public Health and Primary Care University of Cambridge Cambridge UK
Durrer Center for Cardiogenetic Research ICIN Netherlands Heart Institute Utrecht The Netherlands
Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark
Julius Center for Health Sciences and Primary Care University Medical Center Utrecht The Netherlands
MRC Epidemiology Unit Institute of Metabolic Science University of Cambridge UK
National Institute of Public Health Srobarova 48 10042 Prague Czech Republic
- 000
- 00000naa a2200000 a 4500
- 001
- bmc15031885
- 003
- CZ-PrNML
- 005
- 20151008112516.0
- 007
- ta
- 008
- 151005s2014 ie f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.atherosclerosis.2014.07.038 $2 doi
- 035 __
- $a (PubMed)25173947
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ie
- 100 1_
- $a Holmes, Michael V $u Department of Surgery, Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Epidemiology & Public Health, University College London, London, UK. Electronic address: mvholmes@gmail.com.
- 245 12
- $a A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease / $c MV. Holmes, R. Frikke-Schmidt, D. Melis, R. Luben, FW. Asselbergs, JM. Boer, J. Cooper, J. Palmen, P. Horvat, J. Engmann, KW. Li, NC. Onland-Moret, MH. Hofker, M. Kumari, BJ. Keating, JA. Hubacek, V. Adamkova, R. Kubinova, M. Bobak, KT. Khaw, BG. Nordestgaard, N. Wareham, SE. Humphries, C. Langenberg, A. Tybjaerg-Hansen, PJ. Talmud,
- 520 9_
- $a BACKGROUND: Conflicting evidence exists on whether smoking acts as an effect modifier of the association between APOE genotype and risk of coronary heart disease (CHD). METHODS AND RESULTS: We searched PubMed and EMBASE to June 11, 2013 for published studies reporting APOE genotype, smoking status and CHD events and added unpublished data from population cohorts. We tested for presence of effect modification by smoking status in the relationship between APOE genotype and risk of CHD using likelihood ratio test. In total 13 studies (including unpublished data from eight cohorts) with 10,134 CHD events in 130,004 individuals of European descent were identified. The odds ratio (OR) for CHD risk from APOE genotype (ε4 carriers versus non-carriers) was 1.06 (95% confidence interval (CI): 1.01, 1.12) and for smoking (present vs. past/never smokers) was OR 2.05 (95%CI: 1.95, 2.14). When the association between APOE genotype and CHD was stratified by smoking status, compared to non-ε4 carriers, ε4 carriers had an OR of 1.11 (95%CI: 1.02, 1.21) in 28,789 present smokers and an OR of 1.04 (95%CI 0.98, 1.10) in 101,215 previous/never smokers, with no evidence of effect modification (P-value for heterogeneity = 0.19). Analysis of pack years in individual participant data of >60,000 with adjustment for cardiovascular traits also failed to identify evidence of effect modification. CONCLUSIONS: In the largest analysis to date, we identified no evidence for effect modification by smoking status in the association between APOE genotype and risk of CHD.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a alely $7 D000483
- 650 _2
- $a apolipoprotein E4 $x genetika $7 D053327
- 650 _2
- $a kohortové studie $7 D015331
- 650 _2
- $a koronární nemoc $x genetika $7 D003327
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a interakce genů a prostředí $7 D059647
- 650 12
- $a genotyp $7 D005838
- 650 _2
- $a heterozygot $7 D006579
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a kouření $x škodlivé účinky $7 D012907
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a metaanalýza $7 D017418
- 655 _2
- $a Research Support, N.I.H., Extramural $7 D052061
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Frikke-Schmidt, Ruth $u Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
- 700 1_
- $a Melis, Daniela $u Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
- 700 1_
- $a Luben, Robert $u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Asselbergs, Folkert W $u Department of Cardiology, Division Heart & Lungs, University Medical Center, Utrecht, The Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands; Institute of Cardiovascular Science, faculty of Population Health Sciences, University College London, London, United Kingdom. $7 gn_A_00009526
- 700 1_
- $a Boer, Jolanda M A $u Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands.
- 700 1_
- $a Cooper, Jackie $u Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
- 700 1_
- $a Palmen, Jutta $u Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
- 700 1_
- $a Horvat, Pia $u Department of Epidemiology & Public Health, University College London, London, UK.
- 700 1_
- $a Engmann, Jorgen $u Department of Epidemiology & Public Health, University College London, London, UK.
- 700 1_
- $a Li, Ka-Wah $u Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
- 700 1_
- $a Onland-Moret, N Charlotte $u Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
- 700 1_
- $a Hofker, Marten H $u Department of Pediatrics, Molecular Genetics, University Medical Center Groningen and Groningen University, Groningen, The Netherlands.
- 700 1_
- $a Kumari, Meena $u Department of Epidemiology & Public Health, University College London, London, UK.
- 700 1_
- $a Keating, Brendan J $u Department of Surgery, Division of Transplantation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
- 700 1_
- $a Hubacek, Jaroslav A $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 4, 14021, Czech Republic.
- 700 1_
- $a Adamkova, Vera $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 4, 14021, Czech Republic. $7 gn_A_00001463
- 700 1_
- $a Kubinova, Ruzena $u National Institute of Public Health, Srobarova 48, 10042 Prague, Czech Republic.
- 700 1_
- $a Bobak, Martin $u Department of Epidemiology & Public Health, University College London, London, UK.
- 700 1_
- $a Khaw, Kay-Tee $u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Nordestgaard, Børge G $u The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
- 700 1_
- $a Wareham, Nick $u Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
- 700 1_
- $a Humphries, Steve E $u Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
- 700 1_
- $a Langenberg, Claudia $u Department of Epidemiology & Public Health, University College London, London, UK; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, UK.
- 700 1_
- $a Tybjaerg-Hansen, Anne $u Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark; The Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
- 700 1_
- $a Talmud, Philippa J $u Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
- 773 0_
- $w MED00009284 $t Atherosclerosis $x 1879-1484 $g Roč. 237, č. 1 (2014), s. 5-12
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/25173947 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20151005 $b ABA008
- 991 __
- $a 20151008112702 $b ABA008
- 999 __
- $a ok $b bmc $g 1092761 $s 915011
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 237 $c 1 $d 5-12 $e 20140815 $i 1879-1484 $m Atherosclerosis $n Atherosclerosis $x MED00009284
- LZP __
- $a Pubmed-20151005