The ability of four newly developed reversible inhibitors of acetylcholinesterase (PC-37, PC-48, JaKo 39, JaKo 40) and currently available carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was evaluated and compared. No reversible inhibitor of acetylcholinesterase studied was able to decrease the LD50 value of soman in mice. Thus, the pharmacological pre-treatment with pyridostigmine or newly synthesized inhibitors of acetylcholinesterase was not able to significantly protect mice against soman-induced lethal acute toxicity. In addition, neither pyridostigmine nor new reversible inhibitors of acetylcholinesterase was able to increase the efficacy of antidotal treatment (the oxime HI-6 in combination with atropine) of soman-poisoned mice. These findings demonstrate that pharmacological pre-treatment of soman-poisoned mice with tested reversible inhibitors of acetylcholinesterase is not promising.

Department of Toxicology Faculty of Military Health Sciences Hradec Kralove Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc15032017

003      

CZ-PrNML

005      

20151007105535.0

007      

ta

008      

151005s2014 enk f 000 0|eng||

009      

AR

024    7_

$a 10.1111/bcpt.12269 $2 doi

035    __

$a (PubMed)24842281

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a enk

100    1_

$a Kassa, Jiri $u Department of Toxicology, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.

245    14

$a The evaluation of prophylactic efficacy of newly developed reversible inhibitors of acetylcholinesterase in soman-poisoned mice - a comparison with commonly used pyridostigmine / $c J. Kassa, J. Korabecny, V. Sepsova, M. Tumova,

520    9_

$a The ability of four newly developed reversible inhibitors of acetylcholinesterase (PC-37, PC-48, JaKo 39, JaKo 40) and currently available carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of antidotal treatment of soman-poisoned mice was evaluated and compared. No reversible inhibitor of acetylcholinesterase studied was able to decrease the LD50 value of soman in mice. Thus, the pharmacological pre-treatment with pyridostigmine or newly synthesized inhibitors of acetylcholinesterase was not able to significantly protect mice against soman-induced lethal acute toxicity. In addition, neither pyridostigmine nor new reversible inhibitors of acetylcholinesterase was able to increase the efficacy of antidotal treatment (the oxime HI-6 in combination with atropine) of soman-poisoned mice. These findings demonstrate that pharmacological pre-treatment of soman-poisoned mice with tested reversible inhibitors of acetylcholinesterase is not promising.

650    _2

$a zvířata $7 D000818

650    _2

$a antidota $x terapeutické užití $7 D000931

650    _2

$a cholinesterasové inhibitory $x terapeutické užití $7 D002800

650    _2

$a LD50 $7 D007928

650    _2

$a mužské pohlaví $7 D008297

650    _2

$a myši $7 D051379

650    _2

$a piperaziny $x terapeutické užití $7 D010879

650    _2

$a pyridostigmin-bromid $x terapeutické užití $7 D011729

650    _2

$a soman $x antagonisté a inhibitory $x otrava $7 D012999

650    _2

$a takrin $x analogy a deriváty $x terapeutické užití $7 D013619

655    _2

$a srovnávací studie $7 D003160

655    _2

$a časopisecké články $7 D016428

655    _2

$a práce podpořená grantem $7 D013485

700    1_

$a Korabecny, Jan

700    1_

$a Sepsova, Vendula

700    1_

$a Tumova, Martina

773    0_

$w MED00007578 $t Basic & clinical pharmacology & toxicology $x 1742-7843 $g Roč. 115, č. 6 (2014), s. 571-6

856    41

$u https://pubmed.ncbi.nlm.nih.gov/24842281 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y a $z 0

990    __

$a 20151005 $b ABA008

991    __

$a 20151007105721 $b ABA008

999    __

$a ok $b bmc $g 1092893 $s 915143

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2014 $b 115 $c 6 $d 571-6 $e 20140606 $i 1742-7843 $m Basic & clinical pharmacology & toxicology $n Basic Clin Pharmacol Toxicol $x MED00007578

LZP    __

$a Pubmed-20151005