Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Protective effect of ginsenoside against acute renal failure via reduction of renal oxidative stress and enhanced expression of ChAT in the proximal convoluted tubule and ERK1/2 in the paraventricular nuclei

J. Zhou, H. A. Zhang, Y. Lin, H. M. Liu, Y. M. Cui, Y. Xu, N. Zhao, J. M. Ma, K. Fan, C. L. Jiang

. 2014 ; 63 (5) : 597-604. [pub] 20140605

Language English Country Czech Republic

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc15036731

Generation of reactive oxygen species significantly contributes to the pathogenesis of acute renal failure (ARF) induced by myoglobin release. Ginsenosides (GS), the principal active ingredients of ginseng, is considered as an extremely good antioxidative composition of Chinese traditional and herbal drugs. The purpose of the present study was to investigate the protective effect of ginsenoside in rats with ARF on the changes of cholinergic nervous system in the kidney as well as on the involvement of mitogen-activated protein kinases (MAPK) in the hypothalamic paraventricular nuclei (PVN). In our assay, glycerol-induced acute renal failure in rats was employed to study the protective effects of ginsenoside. Our results indicated that the treatment of ARF rats with ginsenosides for 48 h significantly reduced lipid peroxidation, restored the superoxide dismutase (SOD) level. Meanwhile, the obvious increase of choline acetyltransferase-immunoreactivity (ChAT-IR) in the proximal convoluted tubular cells (PCT) was observed by immunohistochemistry in ARF+GS group. The same effect was also observed in the changes of p-ERK1/2-IR in the hypothalamic paraventricular nuclei. Our results suggest that ginsenoside administered orally may have a strong renal protective effect against glycerol-induced ARF, reduce the renal oxidative stress, and ginsenoside can also activate the cholinergic system in PCT, simultaneously MAPK signal pathway in the PVN was also activated.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15036731
003      
CZ-PrNML
005      
20151123141552.0
007      
ta
008      
151120s2014 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.932721 $2 doi
035    __
$a (PubMed)24908085
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Zhou, J. $u Department of Physiology, Dalian Medical University, Dalian, China; Department of Dermatology, Dalian Economic & Technological Developmental Area Hospital, Dalian, China
245    10
$a Protective effect of ginsenoside against acute renal failure via reduction of renal oxidative stress and enhanced expression of ChAT in the proximal convoluted tubule and ERK1/2 in the paraventricular nuclei / $c J. Zhou, H. A. Zhang, Y. Lin, H. M. Liu, Y. M. Cui, Y. Xu, N. Zhao, J. M. Ma, K. Fan, C. L. Jiang
520    9_
$a Generation of reactive oxygen species significantly contributes to the pathogenesis of acute renal failure (ARF) induced by myoglobin release. Ginsenosides (GS), the principal active ingredients of ginseng, is considered as an extremely good antioxidative composition of Chinese traditional and herbal drugs. The purpose of the present study was to investigate the protective effect of ginsenoside in rats with ARF on the changes of cholinergic nervous system in the kidney as well as on the involvement of mitogen-activated protein kinases (MAPK) in the hypothalamic paraventricular nuclei (PVN). In our assay, glycerol-induced acute renal failure in rats was employed to study the protective effects of ginsenoside. Our results indicated that the treatment of ARF rats with ginsenosides for 48 h significantly reduced lipid peroxidation, restored the superoxide dismutase (SOD) level. Meanwhile, the obvious increase of choline acetyltransferase-immunoreactivity (ChAT-IR) in the proximal convoluted tubular cells (PCT) was observed by immunohistochemistry in ARF+GS group. The same effect was also observed in the changes of p-ERK1/2-IR in the hypothalamic paraventricular nuclei. Our results suggest that ginsenoside administered orally may have a strong renal protective effect against glycerol-induced ARF, reduce the renal oxidative stress, and ginsenoside can also activate the cholinergic system in PCT, simultaneously MAPK signal pathway in the PVN was also activated.
650    _2
$a akutní poškození ledvin $x chemicky indukované $x enzymologie $x patologie $x prevence a kontrola $7 D058186
650    _2
$a aplikace orální $7 D000284
650    _2
$a zvířata $7 D000818
650    _2
$a antioxidancia $x aplikace a dávkování $x farmakologie $7 D000975
650    _2
$a cholin-O-acetyltransferasa $x metabolismus $7 D002795
650    _2
$a cytoprotekce $7 D019610
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a ginsenosidy $x aplikace a dávkování $x farmakologie $7 D036145
650    _2
$a glycerol $7 D005990
650    _2
$a proximální tubuly ledvin $x účinky léků $x enzymologie $x patologie $7 D007687
650    _2
$a peroxidace lipidů $x účinky léků $7 D015227
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a malondialdehyd $x metabolismus $7 D008315
650    _2
$a mitogenem aktivovaná proteinkinasa 1 $x metabolismus $7 D019950
650    _2
$a mitogenem aktivovaná proteinkinasa 3 $x metabolismus $7 D048052
650    _2
$a oxidační stres $x účinky léků $7 D018384
650    _2
$a nucleus paraventricularis hypothalami $x účinky léků $x enzymologie $7 D010286
650    _2
$a fosforylace $7 D010766
650    _2
$a potkani Sprague-Dawley $7 D017207
650    _2
$a signální transdukce $x účinky léků $7 D015398
650    _2
$a superoxiddismutasa $x metabolismus $7 D013482
650    _2
$a časové faktory $7 D013997
650    _2
$a upregulace $7 D015854
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Zhang, H. A. $u Department of Physiology, Dalian Medical University, Dalian, China;Division of Cardiovascular Research, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
700    1_
$a Lin, Y. $u Department of Pharmacology, Dalian Medical University, Dalian, China
700    1_
$a Liu, H. M. $u Department of Clinical Medicine, Dalian Medical University, Dalian, China
700    1_
$a Cui, Y. M. $u Department of Clinical Medicine, Dalian Medical University, Dalian, China
700    1_
$a Xu, Y. $u Department of Clinical Medicine, Dalian Medical University, Dalian, China
700    1_
$a Zhao, N. $u Department of Anatomy, Dalian Medical University, Dalian, China
700    1_
$a Ma, J. M. $u Department of Anatomy, Dalian Medical University, Dalian, China
700    1_
$a Fan, K. $u Department of Anatomy, Dalian Medical University, Dalian, China
700    1_
$a Jiang, C. L. $u Department of Physiology, Dalian Medical University, Dalian, China
773    0_
$w MED00003824 $t Physiological research Academia Scientiarum Bohemoslovaca $x 1802-9973 $g Roč. 63, č. 5 (2014), s. 597-604
856    41
$u http://www.biomed.cas.cz/physiolres/ $y domovská stránka časopisu
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20151120 $b ABA008
991    __
$a 20151123093604 $b ABA008
999    __
$a ok $b bmc $g 1098019 $s 919918
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 63 $c 5 $d 597-604 $e 20140605 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20151120

Find record

Citation metrics

Archiving options