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Expression of p16 in squamous cell carcinoma of the mobile tongue is independent of HPV infection despite presence of the HPV-receptor syndecan-1
N. Sgaramella, PJ. Coates, K. Strindlund, L. Loljung, G. Colella, G. Laurell, R. Rossiello, LL. Muzio, C. Loizou, G. Tartaro, K. Olofsson, K. Danielsson, R. Fåhraeus, K. Nylander,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1947 to 1 year ago
Freely Accessible Journals
from 1947 to 1 year ago
PubMed Central
from 1947 to 1 year ago
Europe PubMed Central
from 1947 to 1 year ago
ProQuest Central
from 2000-01-01 to 1 year ago
Open Access Digital Library
from 1947-01-01
Open Access Digital Library
from 1999-01-01
Medline Complete (EBSCOhost)
from 1999-01-01 to 2015-11-17
Nursing & Allied Health Database (ProQuest)
from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2000-01-01 to 1 year ago
PubMed
26057450
DOI
10.1038/bjc.2015.207
Knihovny.cz E-resources
- MeSH
- DNA, Viral analysis MeSH
- Adult MeSH
- In Situ Hybridization MeSH
- Papillomavirus Infections complications MeSH
- Middle Aged MeSH
- Humans MeSH
- Human papillomavirus 16 isolation & purification MeSH
- Neoplasm Proteins analysis physiology MeSH
- Head and Neck Neoplasms mortality virology MeSH
- Tongue Neoplasms mortality virology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Carcinoma, Squamous Cell mortality virology MeSH
- Syndecan-1 analysis physiology MeSH
- Receptors, Virus physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. METHODS: Samples from 109 patients with primary TSCC were analysed for the presence of HPV16 by in situ hybridisation and for expression of its surrogate marker p16 and the HPV receptor syndecan-1 by immunhistochemistry. RESULTS: No evidence of HPV16 DNA was observed in the tumours, although one-third showed p16 staining. There was no difference in the expression of the primary HPV receptor, syndecan-1, between TSCC and a group of tonsil SCC. CONCLUSION: Whereas p16 is expressed in some TSCCs, HPV16 is undetectable, therefore, p16 cannot be used as a surrogate marker for high-risk HPV-infection in this tumour. Despite presence of the HPV-receptor syndecan-1 in TSCC, HPV prefers the tonsillar environment. Lack of p16 associates with worse prognosis primarily in patients aged ⩽40 years with tongue SCC. The improved prognosis seen in p16-positive TSCC can be due to induction of a senescent phenotype or an inherent radiosensitivity due to the ability of p16 to inhibit homologous recombination repair.
Department of Clinical and Experimental Medicine University of Foggia Foggia 71122 Italy
Department of Clinical Sciences ENT Uppsala University Uppsala SE 751 05 Sweden
Department of Medical Biosciences Umeå University Umeå SE 901 85 Sweden
Department of Odontology Umeå University Umeå SE 90185 Sweden
References provided by Crossref.org
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- $a Sgaramella, N $u 1] Department of Medical Biosciences, Umeå University, Umeå SE-901 85, Sweden [2] Multidisciplinary Department of Medical, Surgical and Dental Specialties, Second University of Naples, Naples, Italy.
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- $a BACKGROUND: Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. METHODS: Samples from 109 patients with primary TSCC were analysed for the presence of HPV16 by in situ hybridisation and for expression of its surrogate marker p16 and the HPV receptor syndecan-1 by immunhistochemistry. RESULTS: No evidence of HPV16 DNA was observed in the tumours, although one-third showed p16 staining. There was no difference in the expression of the primary HPV receptor, syndecan-1, between TSCC and a group of tonsil SCC. CONCLUSION: Whereas p16 is expressed in some TSCCs, HPV16 is undetectable, therefore, p16 cannot be used as a surrogate marker for high-risk HPV-infection in this tumour. Despite presence of the HPV-receptor syndecan-1 in TSCC, HPV prefers the tonsillar environment. Lack of p16 associates with worse prognosis primarily in patients aged ⩽40 years with tongue SCC. The improved prognosis seen in p16-positive TSCC can be due to induction of a senescent phenotype or an inherent radiosensitivity due to the ability of p16 to inhibit homologous recombination repair.
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