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Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers
I. Blanco, K. Kuchenbaecker, D. Cuadras, X. Wang, D. Barrowdale, GR. de Garibay, P. Librado, A. Sánchez-Gracia, J. Rozas, N. Bonifaci, L. McGuffog, VS. Pankratz, A. Islam, F. Mateo, A. Berenguer, A. Petit, I. Català, J. Brunet, L. Feliubadaló, E....
Language English Country United States
Document type Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
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- MeSH
- Estrogen Receptor alpha metabolism MeSH
- Hyaluronan Receptors genetics MeSH
- Aurora Kinase A genetics MeSH
- Extracellular Matrix Proteins genetics MeSH
- Genetic Predisposition to Disease genetics MeSH
- Genetic Loci genetics MeSH
- Genes, BRCA1 * MeSH
- Genes, BRCA2 * MeSH
- Nuclear Proteins genetics MeSH
- Polymorphism, Single Nucleotide MeSH
- Carcinogenesis genetics MeSH
- Humans MeSH
- Mammary Glands, Human metabolism MeSH
- Evolution, Molecular MeSH
- Mutation * MeSH
- Breast Neoplasms enzymology genetics pathology MeSH
- Likelihood Functions MeSH
- Microtubule-Associated Proteins genetics MeSH
- Cell Cycle Proteins genetics MeSH
- Retrospective Studies MeSH
- Tubulin genetics MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation carriers. Following on these observations, we further assessed the link between the AURKA-HMMR-TPX2-TUBG1 functional module and risk of breast cancer in BRCA1 or BRCA2 mutation carriers. Forty-one single nucleotide polymorphisms (SNPs) were genotyped in 15,252 BRCA1 and 8,211 BRCA2 mutation carriers and subsequently analyzed using a retrospective likelihood approach. The association of HMMR rs299290 with breast cancer risk in BRCA1 mutation carriers was confirmed: per-allele hazard ratio (HR) = 1.10, 95% confidence interval (CI) 1.04-1.15, p = 1.9 x 10(-4) (false discovery rate (FDR)-adjusted p = 0.043). Variation in CSTF1, located next to AURKA, was also found to be associated with breast cancer risk in BRCA2 mutation carriers: rs2426618 per-allele HR = 1.10, 95% CI 1.03-1.16, p = 0.005 (FDR-adjusted p = 0.045). Assessment of pairwise interactions provided suggestions (FDR-adjusted pinteraction values > 0.05) for deviations from the multiplicative model for rs299290 and CSTF1 rs6064391, and rs299290 and TUBG1 rs11649877 in both BRCA1 and BRCA2 mutation carriers. Following these suggestions, the expression of HMMR and AURKA or TUBG1 in sporadic breast tumors was found to potentially interact, influencing patients' survival. Together, the results of this study support the hypothesis of a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers.
All Wales Medical Genetics Service Glan Clwyd Hospital Rhyl United Kingdom
All Wales Medical Genetics Services Singleton Hospital Swansea United Kingdom
Cancer Epigenetics and Biology Program IDIBELL L'Hospitalet del Llobregat Catalonia Spain
Cancer Genetics Laboratory Department of Genetics University of Pretoria Arcadia South Africa
Catalan Institution for Research and Advanced Studies Barcelona Catalonia Spain
Center for Genomic Medicine Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Center for Individualized Medicine Mayo Clinic Scottsdale Arizona United States of America
Center for Medical Genetics Ghent University Ghent Belgium
Centre François Baclesse Caen France
Clinical Cancer Genetics City of Hope Duarte California United States of America
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark
Department of Clinical Genetics Academic Medical Center Amsterdam The Netherlands
Department of Clinical Genetics Erasmus University Medical Center Rotterdam The Netherlands
Department of Clinical Genetics Helsinki University Central Hospital Helsinki Finland
Department of Clinical Genetics Karolinska University Hospital Stockholm Sweden
Department of Clinical Genetics Leiden University Medical Center Leiden The Netherlands
Department of Clinical Genetics Maastricht University Medical Center Maastricht The Netherlands
Department of Clinical Genetics Odense University Hospital Odense Denmark
Department of Clinical Genetics Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Department of Clinical Genetics Vejle Hospital Vejle Denmark
Department of Epidemiology Columbia University New York New York United States of America
Department of Epidemiology Netherlands Cancer Institute Amsterdam The Netherlands
Department of Genetic Engineering and Biotechnology University of Dhaka Dhaka Bangladesh
Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland
Department of Gynecology and Obstetrics Ludwig Maximilian University Munich Munich Germany
Department of Gynecology and Obstetrics University Hospital Ulm Ulm Germany
Department of Health Sciences Research Mayo Clinic Rochester Minnesota United States of America
Department of Human Genetics Leiden University Medical Center Leiden The Netherlands
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester United States of America
Department of Medical Genetics University Medical Center Utrecht Utrecht The Netherlands
Department of Molecular Genetics National Institute of Oncology Budapest Hungary
Department of Molecular Medicine Sapienza University Rome Italy
Department of Oncology Karolinska University Hospital Stockholm Sweden
Department of Oncology Lund University Hospital Lund Sweden
Department of Oncology Mayo Clinic Rochester Minnesota United States of America
Department of Oncology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Department of Pathology Leiden University Medical Center Leiden The Netherlands
Department of Tumour Biology Institut Curie Paris France
Division of Cancer Medicine Peter MacCallum Cancer Centre East Melbourne Victoria Australia
Family Cancer Clinic Netherlands Cancer Institute Amsterdam The Netherlands
Fondazione Istituto di Oncologia Molecolare Milan Italy
Hereditary Cancer Program Catalan Institute of Oncology Hospital Josep Trueta Girona Catalonia Spain
Hereditary Cancer Program Catalan Institute of Oncology L'Hospitalet del Llobregat Catalonia Spain
Immunology and Molecular Oncology Unit Istituto Oncologico Veneto Padua Italy
Institut National de la Santé et de la Recherche Médicale U830 Institut Curie Paris France
Institute for Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany
Institute of Cell and Molecular Pathology Hannover Medical School Hannover Germany
Institute of Human Genetics Campus Virchov Klinikum Charite Berlin Berlin Germany
Institute of Human Genetics University of Münster Münster Germany
Laboratoire de Génétique Chromosomique Hôtel Dieu Centre Hospitalier Chambéry France
Molecular Genetics of Breast Cancer German Cancer Research Center Heidelberg Germany
Molecular Oncology Laboratory Hospital Clínico San Carlos San Carlos Research Institute Madrid Spain
N N Petrov Institute of Oncology St Petersburg Russia
North West Thames Regional Genetics Service Kennedy Galton Centre Harrow United Kingdom
Oncology Service Hospital de la Santa Creu i Sant Pau Barcelona Catalonia Spain
Queensland Institute of Medical Research Berghofer Medical Research Institute Brisbane Australia
Sackler Faculty of Medicine Tel Aviv University Ramat Aviv Israel
The Institute of Oncology Chaim Sheba Medical Center Ramat Gan Israel
Université Paris Descartes Sorbonne Paris Cité Paris France
Women's College Research Institute University of Toronto Toronto Canada
References provided by Crossref.org
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- 700 1_
- $a van der Luijt, Rob B $u Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
- 700 1_
- $a Ligtenberg, Marjolijn J L $u Department of Human Genetics and Department of Pathology, Radboud university medical center, Nijmegen, The Netherlands.
- 700 1_
- $a Devilee, Peter $u Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
- 700 1_
- $a Wijnen, Juul T $u Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
- 700 1_
- $a Rookus, Matti A $u Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
- 700 1_
- $a Meijers-Heijboer, Hanne E J $u Department of Clinical Genetics, Vrije Universiteit (VU) University Medical Centre, Amsterdam, The Netherlands.
- 700 1_
- $a Blok, Marinus J $u Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
- 700 1_
- $a van den Ouweland, Ans M W $u Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Aalfs, Cora M $u Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.
- 700 1_
- $a Rodriguez, Gustavo C $u Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Chicago, Illinois, United States of America.
- 700 1_
- $a Phillips, Kelly-Anne A $u Division of Cancer Medicine, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
- 700 1_
- $a Piedmonte, Marion $u Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, United States of America.
- 700 1_
- $a Nerenstone, Stacy R $u Central Connecticut Cancer Consortium, Hartford Hospital/Helen and Harry Gray Cancer Center, Hartford, Connecticut, United States of America.
- 700 1_
- $a Bae-Jump, Victoria L $u Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina, United States of America.
- 700 1_
- $a O'Malley, David M $u Division of Gynecologic Oncology, Ohio State University, Columbus Cancer Council, Hilliard, Ohio, United States of America.
- 700 1_
- $a Ratner, Elena S $u Division of Gynecologic Oncology, Yale University School of Medicine, New Haven, Connecticut, United States of America.
- 700 1_
- $a Schmutzler, Rita K $u Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
- 700 1_
- $a Wappenschmidt, Barbara $u Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
- 700 1_
- $a Rhiem, Kerstin $u Centre of Familial Breast and Ovarian Cancer and Centre for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany.
- 700 1_
- $a Engel, Christoph $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Meindl, Alfons $u Department of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
- 700 1_
- $a Ditsch, Nina $u Department of Gynecology and Obstetrics, Ludwig-Maximilian University Munich, Munich, Germany.
- 700 1_
- $a Arnold, Norbert $u Department of Gynecology and Obstetrics, Christian-Albrechts-University of Kiel University Medical Center Schleswig-Holstein, Kiel, Germany.
- 700 1_
- $a Plendl, Hansjoerg J $u Institute of Human Genetics, Christian-Albrechts-University of Kiel University Medical Center Schleswig-Holstein, Kiel, Germany.
- 700 1_
- $a Niederacher, Dieter $u Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
- 700 1_
- $a Sutter, Christian $u Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
- 700 1_
- $a Wang-Gohrke, Shan $u Department of Gynecology and Obstetrics, University Hospital Ulm, Ulm, Germany.
- 700 1_
- $a Steinemann, Doris $u Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.
- 700 1_
- $a Preisler-Adams, Sabine $u Institute of Human Genetics, University of Münster, Münster, Germany.
- 700 1_
- $a Kast, Karin $u Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
- 700 1_
- $a Varon-Mateeva, Raymonda $u Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany.
- 700 1_
- $a Gehrig, Andrea $u Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.
- 700 1_
- $a Bojesen, Anders $u Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
- 700 1_
- $a Pedersen, Inge Sokilde $u Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
- 700 1_
- $a Sunde, Lone $u Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
- 700 1_
- $a Jensen, Uffe Birk $u Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
- 700 1_
- $a Thomassen, Mads $u Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
- 700 1_
- $a Kruse, Torben A $u Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
- 700 1_
- $a Foretova, Lenka $u Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
- 700 1_
- $a Peterlongo, Paolo $u Fondazione Istituto di Oncologia Molecolare (IFOM), Fondazione Italiana per la Ricerca sul Cancro (FIRC), Milan, Italy.
- 700 1_
- $a Bernard, Loris $u Department of Experimental Oncology, Istituto Europeo di Oncologia (IEO), Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
- 700 1_
- $a Peissel, Bernard $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione Istituto Nazionale Tumori (INT), Milan, Italy.
- 700 1_
- $a Scuvera, Giulietta $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione Istituto Nazionale Tumori (INT), Milan, Italy.
- 700 1_
- $a Manoukian, Siranoush $u Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione Istituto Nazionale Tumori (INT), Milan, Italy.
- 700 1_
- $a Radice, Paolo $u Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Fondazione Istituto Nazionale Tumori (INT), Milan, Italy.
- 700 1_
- $a Ottini, Laura $u Department of Molecular Medicine, "Sapienza" University, Rome, Italy.
- 700 1_
- $a Montagna, Marco $u Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padua, Italy.
- 700 1_
- $a Agata, Simona $u Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Padua, Italy.
- 700 1_
- $a Maugard, Christine $u Laboratoire de Diagnostic Génétique et Service d'Onco-Hématologie, Hopitaux Universitaire de Strasbourg, Centre Hospitalier Régional Universitaire (CHRU) Nouvel Hôpital Civil, Strasbourg, France.
- 700 1_
- $a Simard, Jacques $u Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada.
- 700 1_
- $a Soucy, Penny $u Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Canada.
- 700 1_
- $a Berger, Andreas $u Department of Gynecology and Obstetrics, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Fink-Retter, Anneliese $u Department of Gynecology and Obstetrics, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Singer, Christian F $u Department of Gynecology and Obstetrics, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Rappaport, Christine $u Department of Gynecology and Obstetrics, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Geschwantler-Kaulich, Daphne $u Department of Gynecology and Obstetrics, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Tea, Muy-Kheng $u Department of Gynecology and Obstetrics, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Pfeiler, Georg $u Department of Gynecology and Obstetrics, and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a ,
- 700 1_
- $a John, Esther M $u Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, United States of America.
- 700 1_
- $a Miron, Alex $u Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
- 700 1_
- $a Neuhausen, Susan L $u Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, United States of America.
- 700 1_
- $a Terry, Mary Beth $u Department of Epidemiology, Columbia University, New York, New York, United States of America.
- 700 1_
- $a Chung, Wendy K $u Departments of Pediatrics and Medicine, Columbia University Medical Center, New York, New York, United States of America.
- 700 1_
- $a Daly, Mary B $u Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America.
- 700 1_
- $a Goldgar, David E $u Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
- 700 1_
- $a Janavicius, Ramunas $u Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, State Research Centre Institute for Innovative medicine, Vilnius, Lithuania.
- 700 1_
- $a Dorfling, Cecilia M $u Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Arcadia, South Africa.
- 700 1_
- $a van Rensburg, Elisabeth J $u Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Arcadia, South Africa.
- 700 1_
- $a Fostira, Florentia $u Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products (IRRP), National Centre for Scientific Research Demokritos, Athens, Greece.
- 700 1_
- $a Konstantopoulou, Irene $u Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products (IRRP), National Centre for Scientific Research Demokritos, Athens, Greece.
- 700 1_
- $a Garber, Judy $u Center for Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America.
- 700 1_
- $a Godwin, Andrew K $u Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America.
- 700 1_
- $a Olah, Edith $u Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
- 700 1_
- $a Narod, Steven A $u Women's College Research Institute, University of Toronto, Toronto, Canada.
- 700 1_
- $a Rennert, Gad $u Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B Rappaport Faculty of Medicine, Haifa, Israel.
- 700 1_
- $a Paluch, Shani Shimon $u The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
- 700 1_
- $a Laitman, Yael $u The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel.
- 700 1_
- $a Friedman, Eitan $u The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
- 700 1_
- $a ,
- 700 1_
- $a Liljegren, Annelie $u Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.
- 700 1_
- $a Rantala, Johanna $u Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
- 700 1_
- $a Stenmark-Askmalm, Marie $u Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
- 700 1_
- $a Loman, Niklas $u Department of Oncology, Lund University Hospital, Lund, Sweden.
- 700 1_
- $a Imyanitov, Evgeny N $u N.N. Petrov Institute of Oncology, St.-Petersburg, Russia.
- 700 1_
- $a Hamann, Ute $u Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 700 1_
- $a ,
- 700 1_
- $a Spurdle, Amanda B $u Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, Australia.
- 700 1_
- $a Healey, Sue $u Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, Australia.
- 700 1_
- $a Weitzel, Jeffrey N $u Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America.
- 700 1_
- $a Herzog, Josef $u Clinical Cancer Genetics, City of Hope, Duarte, California, United States of America.
- 700 1_
- $a Margileth, David $u St. Joseph Hospital of Orange, Care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, United States of America.
- 700 1_
- $a Gorrini, Chiara $u The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Canada.
- 700 1_
- $a Esteller, Manel $u Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Catalonia, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, L'Hospitalet del Llobregat, Catalonia, Spain; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Catalonia, Spain.
- 700 1_
- $a Gómez, Antonio $u Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Catalonia, Spain.
- 700 1_
- $a Sayols, Sergi $u Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Catalonia, Spain.
- 700 1_
- $a Vidal, Enrique $u Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Catalonia, Spain.
- 700 1_
- $a Heyn, Holger $u Cancer Epigenetics and Biology Program (PEBC), IDIBELL, L'Hospitalet del Llobregat, Catalonia, Spain.
- 700 1_
- $a ,
- 700 1_
- $a Stoppa-Lyonnet, Dominique $u Department of Tumour Biology, Institut Curie, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U830, Institut Curie, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
- 700 1_
- $a Léoné, Melanie $u Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon-Centre Léon Bérard, Lyon, France.
- 700 1_
- $a Barjhoux, Laure $u Institut National de la Santé et de la Recherche Médicale (INSERM) U1052, Centre National de la Recherche Scientifique (CNRS) UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
- 700 1_
- $a Fassy-Colcombet, Marion $u Department of Tumour Biology, Institut Curie, Paris, France.
- 700 1_
- $a de Pauw, Antoine $u Department of Tumour Biology, Institut Curie, Paris, France.
- 700 1_
- $a Lasset, Christine $u Université Lyon 1, Centre National de la Recherche Scientifique (CNRS) UMR5558, and Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
- 700 1_
- $a Ferrer, Sandra Fert $u Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France.
- 700 1_
- $a Castera, Laurent $u Department of Tumour Biology, Institut Curie, Paris, France.
- 700 1_
- $a Berthet, Pascaline $u Centre François Baclesse, Caen, France.
- 700 1_
- $a Cornelis, François $u Genetic Unit, Avicenne Hospital, Assitance Publique-Hôpitaux de Paris, Paris, Sud-Francilien Hospital, Evry-Corbeil, and University Hospital, Clermont-Ferrand, France.
- 700 1_
- $a Bignon, Yves-Jean $u Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France.
- 700 1_
- $a Damiola, Francesca $u Institut National de la Santé et de la Recherche Médicale (INSERM) U1052, Centre National de la Recherche Scientifique (CNRS) UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
- 700 1_
- $a Mazoyer, Sylvie $u Institut National de la Santé et de la Recherche Médicale (INSERM) U1052, Centre National de la Recherche Scientifique (CNRS) UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
- 700 1_
- $a Sinilnikova, Olga M $u Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon-Centre Léon Bérard, Lyon, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1052, Centre National de la Recherche Scientifique (CNRS) UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
- 700 1_
- $a Maxwell, Christopher A $u Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada.
- 700 1_
- $a Vijai, Joseph $u Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
- 700 1_
- $a Robson, Mark $u Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
- 700 1_
- $a Kauff, Noah $u Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
- 700 1_
- $a Corines, Marina J $u Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
- 700 1_
- $a Villano, Danylko $u Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
- 700 1_
- $a Cunningham, Julie $u Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
- 700 1_
- $a Lee, Adam $u Department of Oncology, Mayo Clinic, Rochester, Minnesota, United States of America.
- 700 1_
- $a Lindor, Noralane $u Center for Individualized Medicine, Mayo Clinic, Scottsdale, Arizona, United States of America.
- 700 1_
- $a Lázaro, Conxi $u Hereditary Cancer Program, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Catalonia, Spain.
- 700 1_
- $a Easton, Douglas F $u Epidemiological Study of Familial Breast Cancer (EMBRACE), Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.
- 700 1_
- $a Offit, Kenneth $u Clinical Genetics Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.
- 700 1_
- $a Chenevix-Trench, Georgia $u Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, Australia.
- 700 1_
- $a Couch, Fergus J $u Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, United States of America; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
- 700 1_
- $a Antoniou, Antonis C $u Epidemiological Study of Familial Breast Cancer (EMBRACE), Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom.
- 700 1_
- $a Pujana, Miguel Angel $u Breast Cancer and Systems Biology Unit, Catalan Institute of Oncology (ICO), Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Catalonia, Spain.
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