• Something wrong with this record ?

Transcranial sonography and (123)I-FP-CIT single photon emission computed tomography in movement disorders

P. Bártová, O. Kraft, J. Bernátek, M. Havel, P. Ressner, K. Langová, R. Herzig, D. Skoloudík,

. 2014 ; 40 (10) : 2365-71.

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16000637

Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and (123)I-FP-CIT ([(123)I]ioflupane, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[(123)I]iodophenyl)nortropane) SPECT (single photon emission computed tomography) findings and the diagnosis of PD. A total of 49 patients were enrolled in the study: 29 patients with PD, 7 patients with other parkinsonian syndromes, 11 patients with essential tremor and 2 with psychogenic movement disorder. Substantia nigra echogenicity was measured using TCS. SPECT was performed using DaTSCAN ([(123)I]ioflupane). TCS and SPECT findings were correlated in 84% of patients, with κ = 0.62 (95% confidence interval: 0.38-0.86). TCS-measured substantia nigra echogenicity and SPECT-measured striatal binding ratio were negatively correlated (r = -0.326, p = 0.003). TCS/SPECT sensitivity, specificity and positive and negative predictive values for the diagnosis of PD were 89.7%/96.6%, 60.0%/70.0%, 76.5%/82.4% and 80.0%/93.3%, respectively. Both positive TCS and SPECT findings correlated significantly with the diagnosis of PD (κ = 0.52, 95% confidence interval: 0.27-0.76, and κ = 0.69, 95% confidence interval: 0.49-0.90, respectively).

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16000637
003      
CZ-PrNML
005      
20160127124516.0
007      
ta
008      
160108s2014 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ultrasmedbio.2014.05.014 $2 doi
035    __
$a (PubMed)25194454
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Bártová, Petra $u Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic. Electronic address: petrabartova@seznam.cz.
245    10
$a Transcranial sonography and (123)I-FP-CIT single photon emission computed tomography in movement disorders / $c P. Bártová, O. Kraft, J. Bernátek, M. Havel, P. Ressner, K. Langová, R. Herzig, D. Skoloudík,
520    9_
$a Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and (123)I-FP-CIT ([(123)I]ioflupane, N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[(123)I]iodophenyl)nortropane) SPECT (single photon emission computed tomography) findings and the diagnosis of PD. A total of 49 patients were enrolled in the study: 29 patients with PD, 7 patients with other parkinsonian syndromes, 11 patients with essential tremor and 2 with psychogenic movement disorder. Substantia nigra echogenicity was measured using TCS. SPECT was performed using DaTSCAN ([(123)I]ioflupane). TCS and SPECT findings were correlated in 84% of patients, with κ = 0.62 (95% confidence interval: 0.38-0.86). TCS-measured substantia nigra echogenicity and SPECT-measured striatal binding ratio were negatively correlated (r = -0.326, p = 0.003). TCS/SPECT sensitivity, specificity and positive and negative predictive values for the diagnosis of PD were 89.7%/96.6%, 60.0%/70.0%, 76.5%/82.4% and 80.0%/93.3%, respectively. Both positive TCS and SPECT findings correlated significantly with the diagnosis of PD (κ = 0.52, 95% confidence interval: 0.27-0.76, and κ = 0.69, 95% confidence interval: 0.49-0.90, respectively).
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a diferenciální diagnóza $7 D003937
650    _2
$a esenciální tremor $x radioizotopová diagnostika $x ultrasonografie $7 D020329
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a parkinsonské poruchy $x radioizotopová diagnostika $x ultrasonografie $7 D020734
650    _2
$a prediktivní hodnota testů $7 D011237
650    _2
$a radiofarmaka $7 D019275
650    _2
$a senzitivita a specificita $7 D012680
650    _2
$a substantia nigra $x radioizotopová diagnostika $7 D013378
650    _2
$a jednofotonová emisní výpočetní tomografie $x metody $7 D015899
650    _2
$a tropany $7 D014326
650    _2
$a ultrasonografie dopplerovská transkraniální $x metody $7 D017585
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Kraft, Otakar $u Department of Nuclear Medicine, University Hospital, Ostrava, Czech Republic.
700    1_
$a Bernátek, Jaromír $u Department of Nuclear Medicine, Bata Hospital Zlín, Zlín, Czech Republic.
700    1_
$a Havel, Martin $u Department of Nuclear Medicine, University Hospital, Ostrava, Czech Republic.
700    1_
$a Ressner, Pavel $u Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic.
700    1_
$a Langová, Kateřina $u Department of Biophysics, Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacký University, Olomouc, Czech Republic.
700    1_
$a Herzig, Roman $u Department of Neurology, Faculty of Medicine, Charles University, Hradec Králové, Czech Republic.
700    1_
$a Skoloudík, David $u Department of Neurology, Ostrava University and University Hospital, Ostrava, Czech Republic; Department of Nursing, Faculty of Health Science, Palacký University and University Hospital, Olomouc, Czech Republic.
773    0_
$w MED00004601 $t Ultrasound in medicine & biology $x 1879-291X $g Roč. 40, č. 10 (2014), s. 2365-71
856    41
$u https://pubmed.ncbi.nlm.nih.gov/25194454 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160108 $b ABA008
991    __
$a 20160127124641 $b ABA008
999    __
$a ok $b bmc $g 1102918 $s 924843
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 40 $c 10 $d 2365-71 $i 1879-291X $m Ultrasound in medicine & biology $n Ultrasound Med Biol $x MED00004601
LZP    __
$a Pubmed-20160108
Back

Find record

Citation metrics

Logged in users only

Archiving options