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Molecular typing of Treponema pallidum in the Czech Republic during 2011 to 2013: increased prevalence of identified genotypes and of isolates with macrolide resistance

L. Grillová, H. Pĕtrošová, L. Mikalová, R. Strnadel, E. Dastychová, I. Kuklová, M. Kojanová, M. Kreidlová, D. Vaňousová, J. Hercogová, P. Procházka, H. Zákoucká, A. Krchňáková, V. Vašků, D. Šmajs,

. 2014 ; 52 (10) : 3693-3700. [pub] 20140806

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16000673

Grantová podpora
NT11159 MZ0 CEP - Centrální evidence projektů

Digitální knihovna NLK
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NLK Free Medical Journals od 1975 do Před 6 měsíci
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Open Access Digital Library od 1975-01-01

Odkazy

PubMed 25100820
DOI 10.1128/jcm.01292-14
Knihovny.cz E-zdroje

From January 2011 to December 2013, a total of 262 samples, from 188 patients suspected of having syphilis were tested for the presence of treponemal DNA by PCR amplification of five chromosomal loci, including the polA (TP0105), tmpC (TP0319), TP0136, TP0548, and 23S rRNA genes. Altogether, 146 samples from 103 patients were PCR positive for treponemal DNA. A set of 81 samples from 62 PCR-positive patients were typeable, and among them, nine different genotypes were identified. Compared to a previous study in the Czech Republic during 2004 to 2010, the number of genotypes detected among syphilis patients in a particular year increased to six in both 2012 and 2013, although they were not the same six. The proportion of macrolide-resistant clinical isolates in this 3-year study was 66.7%.

Citace poskytuje Crossref.org

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