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DNA repair mechanisms and human cytomegalovirus (HCMV) infection
B. Smolarz, J. Wilczyński, D. Nowakowska,
Language English Country United States
Document type Journal Article, Review
- MeSH
- Cytomegalovirus Infections enzymology genetics metabolism microbiology MeSH
- Cytomegalovirus physiology MeSH
- DNA Repair Enzymes genetics metabolism MeSH
- Humans MeSH
- DNA Repair * MeSH
- DNA Damage MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Herpesvirus infections, such as those induced by human cytomegalovirus (HCMV), induce specific DNA damages. DNA damages can lead to cell mutation, death, apoptosis and immune system activation. Various types of DNA damage are repaired through multiple repair pathways, such as base excision, nucleotide excision, homologous recombination and nonhomologous end joining. Changes in the activity of DNA repair proteins during viral infection can cause disturbances in the DNA repair system and change its mechanisms. This report reviews results from studies, assaying a DNA repair system in HCMV infection.
References provided by Crossref.org
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- $a Herpesvirus infections, such as those induced by human cytomegalovirus (HCMV), induce specific DNA damages. DNA damages can lead to cell mutation, death, apoptosis and immune system activation. Various types of DNA damage are repaired through multiple repair pathways, such as base excision, nucleotide excision, homologous recombination and nonhomologous end joining. Changes in the activity of DNA repair proteins during viral infection can cause disturbances in the DNA repair system and change its mechanisms. This report reviews results from studies, assaying a DNA repair system in HCMV infection.
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