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History of organophosphorus cholinesterase inhibitors & reactivators

Georg Petroianu

. 2015 ; 84 (4) : 182-185.

Jazyk angličtina Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc16007869

It was with interest and pleasure that I read the contribution of Petronilho & Figueroa-Villaret in the MMSL reviewing the literature on agents for defense against chemical warfare [Petronilho & Figueroa-Villaret, 2015]. The authors briefly touch on the history of organophosphates emphasizing the pioneering contribution of Jean Louis Lassaigne, the synthesis of triethyl- phosphate (TEP) and finally the achievements of Philippe de Clermont who codeveloped the first organophosphate (OP) acetylcholinesterase inhibitor, tetraethyl pyrophosphate (TEEP). They continue by pointing out that Wilson and Ginsburg managed to reactivate OP-inhibited acetylcholinesterase using pralidoxime (2 -PAM), which reactivates the enzyme much faster than hydroxylamine. I believe that the scientists involved in organophosphorus cholinesterase inhibitor & reactivator development deserve more attention and that the colleagues’ contribution contains a number of ambiguities deserving additional.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

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