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Carmellose Mucoadhesive Oral Films Containing Vermiculite/Chlorhexidine Nanocomposites as Innovative Biomaterials for Treatment of Oral Infections
J. Gajdziok, S. Holešová, J. Štembírek, E. Pazdziora, H. Landová, P. Doležel, D. Vetchý,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NT14477
MZ0
CEP Register
NLK
Free Medical Journals
from 2013
PubMed Central
from 2013
Europe PubMed Central
from 2013
ProQuest Central
from 2013
Open Access Digital Library
from 2001-01-01
Open Access Digital Library
from 2012-12-04
Open Access Digital Library
from 2013-01-01
CINAHL Plus with Full Text (EBSCOhost)
from 2013-01-01
Medline Complete (EBSCOhost)
from 2013-01-01
Health & Medicine (ProQuest)
from 2013
Wiley-Blackwell Open Access Titles
from 2001
ROAD: Directory of Open Access Scholarly Resources
from 2013
PubMed
26064926
DOI
10.1155/2015/580146
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents administration & dosage chemistry MeSH
- Biocompatible Materials administration & dosage chemistry MeSH
- Chitosan chemistry MeSH
- Chlorhexidine administration & dosage chemistry MeSH
- Chemistry, Pharmaceutical MeSH
- Drug Delivery Systems * MeSH
- Humans MeSH
- Nanocomposites administration & dosage chemistry MeSH
- Polymers administration & dosage chemistry MeSH
- Carboxymethylcellulose Sodium administration & dosage chemistry MeSH
- Stomatitis drug therapy microbiology MeSH
- Mouth drug effects microbiology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Infectious stomatitis represents the most common oral cavity ailments. Current therapy is insufficiently effective because of the short residence time of topical liquid or semisolid medical formulations. An innovative application form based on bioadhesive polymers featuring prolonged residence time on the oral mucosa may be a solution to this challenge. This formulation consists of a mucoadhesive oral film with incorporated nanocomposite biomaterial that is able to release the drug directly at the target area. This study describes the unique approach of preparing mucoadhesive oral films from carmellose with incorporating a nanotechnologically modified clay mineral intercalated with chlorhexidine. The multivariate data analysis was employed to evaluate the influence of the formulation and process variables on the properties of the medical preparation. This evaluation was complemented by testing the antimicrobial and antimycotic activity of prepared films with the aim of finding the most suitable composition for clinical application. Generally, the best results were obtained with sample containing 20 mg of chlorhexidine diacetate carried by vermiculite, with carmellose in the form of nonwoven textile in its structure. In addition to its promising physicomechanical, chemical, and mucoadhesive properties, the formulation inhibited the growth of Staphylococcus and Candida; the effect was prolonged for tens of hours.
References provided by Crossref.org
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