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Effect of pterostilbene on lipids and lipid profiles in streptozotocin–nicotinamide induced type 2 diabetes mellitus
Marudamuthu Amarnath Satheesh, Leelavinothan Pari
Jazyk angličtina Země Česko
NLK
Free Medical Journals
od 2003 do 2013
Freely Accessible Science Journals
od 2003 do 2013
ROAD: Directory of Open Access Scholarly Resources
od 2002
- MeSH
- diabetes mellitus 2. typu farmakoterapie komplikace metabolismus MeSH
- hypoglykemika metabolismus terapeutické užití MeSH
- hypolipidemika metabolismus terapeutické užití MeSH
- lipoproteiny chemie metabolismus MeSH
- mastné kyseliny metabolismus MeSH
- poruchy metabolismu lipidů komplikace metabolismus MeSH
- potkani Wistar metabolismus MeSH
- receptory aktivované proliferátory peroxizomů metabolismus MeSH
- stilbeny chemie metabolismus MeSH
- streptozocin aplikace a dávkování metabolismus MeSH
Hyperlipidaemia is one of the major risk factors of cardiovascular complication in diabetes. A study was undertaken to evaluate the antihyperlipidaemic activity of pterostilbene. Oral administration of pterostilbene (40mg/kg bodyweight) to streptozotocin-nicotinamide induced diabetic rats for 6 weeks significantly reduced the elevated serum very low density lipoprotein (VLDL) and low density lipoprotein (LDL)-cholesterol levels and significantly increased the serum high-density lipoprotein (HDL)-cholesterol level. In addition, pterostilbene also significantly lowered the levels of triglycerides, phospholipids, free fatty acids and total cholesterol in the serum, liver and kidney of diabetic rats.
Department of Biochemistry and Biotechnology Faculty of Science Annamalai University Annamalai Nagar
Citace poskytuje Crossref.org
Lit.: 31
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- $a Hyperlipidaemia is one of the major risk factors of cardiovascular complication in diabetes. A study was undertaken to evaluate the antihyperlipidaemic activity of pterostilbene. Oral administration of pterostilbene (40mg/kg bodyweight) to streptozotocin-nicotinamide induced diabetic rats for 6 weeks significantly reduced the elevated serum very low density lipoprotein (VLDL) and low density lipoprotein (LDL)-cholesterol levels and significantly increased the serum high-density lipoprotein (HDL)-cholesterol level. In addition, pterostilbene also significantly lowered the levels of triglycerides, phospholipids, free fatty acids and total cholesterol in the serum, liver and kidney of diabetic rats.
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