Infectious stomatitis represents the most common oral cavity ailments. Current therapy is insufficiently effective because of the short residence time of topical liquid or semisolid medical formulations. An innovative application form based on bioadhesive polymers featuring prolonged residence time on the oral mucosa may be a solution to this challenge. This formulation consists of a mucoadhesive oral film with incorporated nanocomposite biomaterial that is able to release the drug directly at the target area. This study describes the unique approach of preparing mucoadhesive oral films from carmellose with incorporating a nanotechnologically modified clay mineral intercalated with chlorhexidine. The multivariate data analysis was employed to evaluate the influence of the formulation and process variables on the properties of the medical preparation. This evaluation was complemented by testing the antimicrobial and antimycotic activity of prepared films with the aim of finding the most suitable composition for clinical application. Generally, the best results were obtained with sample containing 20 mg of chlorhexidine diacetate carried by vermiculite, with carmellose in the form of nonwoven textile in its structure. In addition to its promising physicomechanical, chemical, and mucoadhesive properties, the formulation inhibited the growth of Staphylococcus and Candida; the effect was prolonged for tens of hours.
- MeSH
- antiinfekční látky aplikace a dávkování chemie MeSH
- biokompatibilní materiály aplikace a dávkování chemie MeSH
- chemie farmaceutická MeSH
- chitosan chemie MeSH
- chlorhexidin aplikace a dávkování chemie MeSH
- lidé MeSH
- nanokompozity aplikace a dávkování chemie MeSH
- polymery aplikace a dávkování chemie MeSH
- sodná sůl karboxymethylcelulosy aplikace a dávkování chemie MeSH
- stomatitida farmakoterapie mikrobiologie MeSH
- systémy cílené aplikace léků * MeSH
- ústa účinky léků mikrobiologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
