• Je něco špatně v tomto záznamu ?

Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model

P. Dostal, J. Schreiberova, V. Dostalova, V. Dostalova, T. Tyll, J. Paral, I. Abdo, M. Cihlo, D. Astapenko, Z. Turek,

. 2015 ; 15 (-) : 88. [pub] 20150609

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16010115

BACKGROUND: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model. METHODS: Rabbits (weight, 2.0-3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3.75 ml/kg intravenous infusion of either 3.2% HTS (group HTS, n = 8) or 20% mannitol (group MTL, n = 8). Microcirculation in the cerebral cortex was evaluated using sidestream dark-field (SDF) imaging before and 20 min after the end of the 15-min HTS infusion. Global hemodynamic data were recorded, and blood samples for laboratory analysis were obtained at the time of SDF image recording. RESULTS: No differences in the microcirculatory parameters were observed between the groups before the use of osmotherapy. After osmotherapy, lower proportions of perfused small vessel density (P = 0.0474), perfused vessel density (P = 0.0457), and microvascular flow index (P = 0.0207) were observed in the MTL group compared with those in the HTS group. CONCLUSIONS: Our findings suggest that an equivolemic, equiosmolar HTS solution better preserves perfusion of cortical brain microcirculation compared to MTL in a rabbit craniotomy model.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16010115
003      
CZ-PrNML
005      
20160412122600.0
007      
ta
008      
160408s2015 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12871-015-0067-z $2 doi
024    7_
$a 10.1186/s12871-015-0067-z $2 doi
035    __
$a (PubMed)26055873
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Dostal, Pavel $u Department of Anesthesia and Intensive Care Medicine, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. pavel.dostal@fnhk.cz.
245    10
$a Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model / $c P. Dostal, J. Schreiberova, V. Dostalova, V. Dostalova, T. Tyll, J. Paral, I. Abdo, M. Cihlo, D. Astapenko, Z. Turek,
520    9_
$a BACKGROUND: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model. METHODS: Rabbits (weight, 2.0-3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3.75 ml/kg intravenous infusion of either 3.2% HTS (group HTS, n = 8) or 20% mannitol (group MTL, n = 8). Microcirculation in the cerebral cortex was evaluated using sidestream dark-field (SDF) imaging before and 20 min after the end of the 15-min HTS infusion. Global hemodynamic data were recorded, and blood samples for laboratory analysis were obtained at the time of SDF image recording. RESULTS: No differences in the microcirculatory parameters were observed between the groups before the use of osmotherapy. After osmotherapy, lower proportions of perfused small vessel density (P = 0.0474), perfused vessel density (P = 0.0457), and microvascular flow index (P = 0.0207) were observed in the MTL group compared with those in the HTS group. CONCLUSIONS: Our findings suggest that an equivolemic, equiosmolar HTS solution better preserves perfusion of cortical brain microcirculation compared to MTL in a rabbit craniotomy model.
650    _2
$a zvířata $7 D000818
650    _2
$a mozková kůra $x krevní zásobení $x účinky léků $7 D002540
650    _2
$a mozkový krevní oběh $x účinky léků $7 D002560
650    _2
$a kraniotomie $x metody $7 D003399
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a hemodynamika $x účinky léků $7 D006439
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a mannitol $x farmakologie $7 D008353
650    _2
$a mikrocirkulace $x účinky léků $7 D008833
650    _2
$a králíci $7 D011817
650    _2
$a hypertonický solný roztok $x farmakologie $7 D012462
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Schreiberova, Jitka $u Department of Anesthesia and Intensive Care Medicine, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. jitka.schreiberova@fnhk.cz.
700    1_
$a Dostalova, Vlasta $u Department of Anesthesia and Intensive Care Medicine, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. vlasta.dostalova@fnhk.cz.
700    1_
$a Dostalova, Vlasta $u Department of Anesthesia and Intensive Care Medicine, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. vlahado@seznam.cz.
700    1_
$a Tyll, Tomas $u Department of Anesthesia and Intensive Care Medicine, Charles University, 1st Faculty of Medicine Prague, Military University Hospital Prague, Prague, Czech Republic. tomas.tyll@uvn.cz.
700    1_
$a Paral, Jiri $u Department of Military Surgery, Faculty of Military Health Sciences, Hradec Kralove, University of Defence, Brno, Czech Republic. jiri.paral@seznam.cz.
700    1_
$a Abdo, Islam $u Department of Anesthesia and Intensive Care Medicine, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. islamsalehabdo@gmail.cz. $7 gn_A_00000398
700    1_
$a Cihlo, Miroslav $u Department of Neurosurgery, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. miroslav.cihlo@fnhk.cz.
700    1_
$a Astapenko, David $u Department of Anesthesia and Intensive Care Medicine, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. david.astapenko@fnhk.cz. $7 gn_A_00009572
700    1_
$a Turek, Zdenek $u Department of Anesthesia and Intensive Care Medicine, Charles University, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. zdenek.turek@fnhk.cz.
773    0_
$w MED00006769 $t BMC anesthesiology $x 1471-2253 $g Roč. 15, č. - (2015), s. 88
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26055873 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20160408 $b ABA008
991    __
$a 20160412122643 $b ABA008
999    __
$a ok $b bmc $g 1113544 $s 934483
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2015 $b 15 $c - $d 88 $e 20150609 $i 1471-2253 $m BMC anesthesiology $n BMC Anesthesiol $x MED00006769
LZP    __
$a Pubmed-20160408

Najít záznam

Citační ukazatele

Možnosti archivace