-
Je něco špatně v tomto záznamu ?
Changes of the complement system and rheological indicators after therapy with rheohemapheresis
M. Blaha, C. Andrys, H. Langrova, J. Studnicka, J. Drsata, M. Lanska, V. Blaha, P. Zak,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NT14265
MZ0
CEP - Centrální evidence projektů
NT14037
MZ0
CEP - Centrální evidence projektů
NT13475
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Plný text - Článek
Plný text - Článek
Zdroj
Zdroj
Zdroj
- MeSH
- aktivace komplementu * MeSH
- komplement - faktor H metabolismus MeSH
- komplement metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- makulární degenerace krev diagnóza imunologie terapie MeSH
- náhlá nedoslýchavost krev diagnóza imunologie terapie MeSH
- percepční nedoslýchavost krev diagnóza imunologie terapie MeSH
- reologie krve * MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- separace krevních složek metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
INTRODUCTION: In the last 10 years, many studies have been published on the role of the complement system in microcirculation disorders. However, as for the changes of complement components after rheohemapheresis, there is still a lack of detailed data in the literature. Complement changes may play an important role in pathogenesis of some microcirculation disorders, such as age-related macular degeneration and acute hearing loss. The objective of this study was to investigate the effect of rheohemapheresis on the basic complement pathways. PATIENTS AND METHODS: 32 patients were treated with rheohemapheresis, including 16 patients (10 men and 6 women) for age-related macular degeneration (AMD), mean age 69.7 ± 6.06 years (range 62-87 years) and 16 patients (11 men and 5 women) aged 56.4 ± 11.5 (range 34-73 years) for acute hearing loss. RESULTS: Rheohemapheresis led to a significant drop of all three complement-activation pathways in both groups of patients. Moreover, complement factor H was also reduced. CONCLUSION: The observed reduction in all three basic complement activation pathways after rheohemapheresis could be clinically important. The search continues both to find substances which influence complement systems and to develop more effective new drugs that require less frequent administration and that provide improved intraocular therapy for AMD patients.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16010239
- 003
- CZ-PrNML
- 005
- 20191126102743.0
- 007
- ta
- 008
- 160408s2015 ne f 000 0|engg|
- 009
- AR
- 024 7_
- $a 10.1016/j.atherosclerosissup.2015.02.009 $2 doi
- 024 7_
- $a 10.1016/j.atherosclerosissup.2015.02.009 $2 doi
- 035 __
- $a (PubMed)25936318
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Bláha, Milan, $u 4th Department of Internal Medicine - Hematology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. Electronic address: blaham@email.cz. $d 1938- $7 xx0034440
- 245 10
- $a Changes of the complement system and rheological indicators after therapy with rheohemapheresis / $c M. Blaha, C. Andrys, H. Langrova, J. Studnicka, J. Drsata, M. Lanska, V. Blaha, P. Zak,
- 520 9_
- $a INTRODUCTION: In the last 10 years, many studies have been published on the role of the complement system in microcirculation disorders. However, as for the changes of complement components after rheohemapheresis, there is still a lack of detailed data in the literature. Complement changes may play an important role in pathogenesis of some microcirculation disorders, such as age-related macular degeneration and acute hearing loss. The objective of this study was to investigate the effect of rheohemapheresis on the basic complement pathways. PATIENTS AND METHODS: 32 patients were treated with rheohemapheresis, including 16 patients (10 men and 6 women) for age-related macular degeneration (AMD), mean age 69.7 ± 6.06 years (range 62-87 years) and 16 patients (11 men and 5 women) aged 56.4 ± 11.5 (range 34-73 years) for acute hearing loss. RESULTS: Rheohemapheresis led to a significant drop of all three complement-activation pathways in both groups of patients. Moreover, complement factor H was also reduced. CONCLUSION: The observed reduction in all three basic complement activation pathways after rheohemapheresis could be clinically important. The search continues both to find substances which influence complement systems and to develop more effective new drugs that require less frequent administration and that provide improved intraocular therapy for AMD patients.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a separace krevních složek $x metody $7 D001781
- 650 12
- $a aktivace komplementu $7 D003167
- 650 _2
- $a komplement - faktor H $x metabolismus $7 D017242
- 650 _2
- $a komplement $x metabolismus $7 D003165
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a percepční nedoslýchavost $x krev $x diagnóza $x imunologie $x terapie $7 D006319
- 650 _2
- $a náhlá nedoslýchavost $x krev $x diagnóza $x imunologie $x terapie $7 D003639
- 650 12
- $a reologie krve $7 D018056
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a makulární degenerace $x krev $x diagnóza $x imunologie $x terapie $7 D008268
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a výsledek terapie $7 D016896
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Andrýs, Ctirad $u Institute of Immunology and Allergology, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. $7 mzk2008430528
- 700 1_
- $a Langrová, Hana, $u Department of Ophthalmology, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. $d 1971- $7 xx0062299
- 700 1_
- $a Studnička, Jan $u Department of Ophthalmology, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. $7 jx20090420023
- 700 1_
- $a Dršata, Jakub, $u Department of Otorhinolaryngology, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. $d 1970- $7 xx0077630
- 700 1_
- $a Lánská, Miriam $u 4th Department of Internal Medicine - Hematology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. $7 jx20100315020
- 700 1_
- $a Bláha, Vladimír, $u 3rd Department of Medicine - Metabolic Care and Gerontology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. $d 1964- $7 xx0002944
- 700 1_
- $a Žák, Pavel, $u 4th Department of Internal Medicine - Hematology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic. $d 1966- $7 mzk2006354145
- 773 0_
- $w MED00006853 $t Atherosclerosis. Supplements $x 1878-5050 $g Roč. 18, č. - (2015), s. 140-145
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/25936318 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20160408 $b ABA008
- 991 __
- $a 20191126103029 $b ABA008
- 999 __
- $a ok $b bmc $g 1113668 $s 934607
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 18 $c - $d 140-145 $i 1878-5050 $m Atherosclerosis supplements $n Atheroscler Suppl $x MED00006853
- GRA __
- $a NT14265 $p MZ0
- GRA __
- $a NT14037 $p MZ0
- GRA __
- $a NT13475 $p MZ0
- LZP __
- $a Pubmed-20160408
