-
Something wrong with this record ?
Tobacco smoking strongly modifies the association of prothrombin G20210A with undetermined stroke: consecutive survivors and population-based controls
A. Krajcoviechova, P. Wohlfahrt, O. Mayer, J. Vanek, J. Hajkova, D. Hlinovsky, T. Kvasnicka, J. Tremblay, P. Hamet, J. Filipovsky, J. Kvasnicka, R. Cifkova,
Language English Country Ireland
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NT12102
MZ0
CEP Register
- MeSH
- Stroke diagnosis epidemiology genetics MeSH
- Adult MeSH
- Phenotype MeSH
- Gene Frequency MeSH
- Genetic Predisposition to Disease MeSH
- Heterozygote MeSH
- Risk Assessment MeSH
- Homozygote MeSH
- Brain Ischemia diagnosis epidemiology genetics MeSH
- Smoking adverse effects epidemiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Logistic Models MeSH
- Adolescent MeSH
- Young Adult MeSH
- Multivariate Analysis MeSH
- Odds Ratio MeSH
- Polymorphism, Genetic * MeSH
- Prevalence MeSH
- Prothrombin genetics MeSH
- Risk Factors MeSH
- Chi-Square Distribution MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Case-Control Studies MeSH
- Thrombophilia blood complications diagnosis epidemiology genetics MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
OBJECTIVE: Due to contradictory results of previous studies evaluating the association between ischemic stroke (IS) and thrombophilic polymorphisms, their routine screening in IS patients, particularly those older than 60 years, is not recommended. We evaluated the differences in the distribution of rs6025 and rs1799963 polymorphisms according to IS subtypes and their interaction with smoking. METHODS: We conducted a case-control study of 423 hospital-based consecutive survivors of their first-ever IS and 614 population-based controls. Survivors (18-81 years) with IS documented by brain imagining were examined at a median of 16 months after the index event. The stroke subtype was categorized using the Causative Classification of Stroke System. Controls (50-75 years) were free of a history of stroke/TIA, coronary heart disease, and venous thromboembolism. RESULTS: Age- and gender-adjusted prevalence of individuals carrying at least one copy of the rs1799963A minor allele was 5.3% among stroke survivors (by subtypes: 3.1% in large artery atherosclerosis, 2.0% in cardio-aortic embolism, 2.4% in small artery occlusion, and 10.3% in undetermined stroke) vs. 2.4% among controls. In multinomial multivariate adjusted analysis, rs1799963 was exclusively associated with undetermined stroke (OR: 3.67; 95% CI: 1.52-8.85; p = 0.004). There was strong evidence of rs1799963 × smoking synergistic interaction (OR: 5.14; 95% CI: 1.65-16.01; p = 0.005). There was no association of rs6025 with IS in general, or with any subtype. CONCLUSIONS: In our consecutive IS survivors, carriage of the rs1799963A allele is associated with undetermined stroke. This effect appears to be confined to smokers.
Department of Neurology of Thomayer Hospital Prague Czech Republic
Montreal University Hospital Research Center CRCHUM Montreal Canada
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16010289
- 003
- CZ-PrNML
- 005
- 20170425101500.0
- 007
- ta
- 008
- 160408s2015 ie f 000 0|engg|
- 009
- AR
- 024 7_
- $a 10.1016/j.atherosclerosis.2015.04.010 $2 doi
- 024 7_
- $a 10.1016/j.atherosclerosis.2015.04.010 $2 doi
- 035 __
- $a (PubMed)25897999
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ie
- 100 1_
- $a Krajčoviechová, Alena $u Center for Cardiovascular Prevention, First Medical School of Charles University in Prague and Thomayer Hospital, Czech Republic. Electronic address: alena.krajcoviechova@ftn.cz. $7 xx0095262
- 245 10
- $a Tobacco smoking strongly modifies the association of prothrombin G20210A with undetermined stroke: consecutive survivors and population-based controls / $c A. Krajcoviechova, P. Wohlfahrt, O. Mayer, J. Vanek, J. Hajkova, D. Hlinovsky, T. Kvasnicka, J. Tremblay, P. Hamet, J. Filipovsky, J. Kvasnicka, R. Cifkova,
- 520 9_
- $a OBJECTIVE: Due to contradictory results of previous studies evaluating the association between ischemic stroke (IS) and thrombophilic polymorphisms, their routine screening in IS patients, particularly those older than 60 years, is not recommended. We evaluated the differences in the distribution of rs6025 and rs1799963 polymorphisms according to IS subtypes and their interaction with smoking. METHODS: We conducted a case-control study of 423 hospital-based consecutive survivors of their first-ever IS and 614 population-based controls. Survivors (18-81 years) with IS documented by brain imagining were examined at a median of 16 months after the index event. The stroke subtype was categorized using the Causative Classification of Stroke System. Controls (50-75 years) were free of a history of stroke/TIA, coronary heart disease, and venous thromboembolism. RESULTS: Age- and gender-adjusted prevalence of individuals carrying at least one copy of the rs1799963A minor allele was 5.3% among stroke survivors (by subtypes: 3.1% in large artery atherosclerosis, 2.0% in cardio-aortic embolism, 2.4% in small artery occlusion, and 10.3% in undetermined stroke) vs. 2.4% among controls. In multinomial multivariate adjusted analysis, rs1799963 was exclusively associated with undetermined stroke (OR: 3.67; 95% CI: 1.52-8.85; p = 0.004). There was strong evidence of rs1799963 × smoking synergistic interaction (OR: 5.14; 95% CI: 1.65-16.01; p = 0.005). There was no association of rs6025 with IS in general, or with any subtype. CONCLUSIONS: In our consecutive IS survivors, carriage of the rs1799963A allele is associated with undetermined stroke. This effect appears to be confined to smokers.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a ischemie mozku $x diagnóza $x epidemiologie $x genetika $7 D002545
- 650 _2
- $a studie případů a kontrol $7 D016022
- 650 _2
- $a rozdělení chí kvadrát $7 D016009
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a frekvence genu $7 D005787
- 650 _2
- $a genetická predispozice k nemoci $7 D020022
- 650 _2
- $a heterozygot $7 D006579
- 650 _2
- $a homozygot $7 D006720
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a logistické modely $7 D016015
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a multivariační analýza $7 D015999
- 650 _2
- $a odds ratio $7 D016017
- 650 _2
- $a fenotyp $7 D010641
- 650 12
- $a polymorfismus genetický $7 D011110
- 650 _2
- $a prevalence $7 D015995
- 650 _2
- $a protrombin $x genetika $7 D011516
- 650 _2
- $a hodnocení rizik $7 D018570
- 650 _2
- $a rizikové faktory $7 D012307
- 650 _2
- $a kouření $x škodlivé účinky $x epidemiologie $7 D012907
- 650 _2
- $a cévní mozková příhoda $x diagnóza $x epidemiologie $x genetika $7 D020521
- 650 _2
- $a trombofilie $x krev $x komplikace $x diagnóza $x epidemiologie $x genetika $7 D019851
- 650 _2
- $a mladý dospělý $7 D055815
- 651 _2
- $a Česká republika $x epidemiologie $7 D018153
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Wohlfahrt, Peter $u Center for Cardiovascular Prevention, First Medical School of Charles University in Prague and Thomayer Hospital, Czech Republic. $7 xx0230851
- 700 1_
- $a Mayer, Otto, $u 2nd Department of Internal Medicine, Charles University Medical Faculty and Teaching Hospital, Pilsen, Czech Republic. $d 1969- $7 xx0053346
- 700 1_
- $a Vaněk, Jiří $u 2nd Department of Internal Medicine, Charles University Medical Faculty and Teaching Hospital, Pilsen, Czech Republic. $7 xx0273624
- 700 1_
- $a Hájková, Jaroslava $u Central Laboratory for Hematology and Thrombotic Centre, First Medical School of Charles University in Prague and General Teaching Hospital, Prague, Czech Republic. $7 xx0121179
- 700 1_
- $a Hlinovský, David $u Department of Neurology of Thomayer Hospital in Prague, Czech Republic. $7 xx0270534
- 700 1_
- $a Kvasnička, Tomáš $u Central Laboratory for Hematology and Thrombotic Centre, First Medical School of Charles University in Prague and General Teaching Hospital, Prague, Czech Republic. $7 xx0061420
- 700 1_
- $a Tremblay, J $u Montreal University Hospital Research Center, CRCHUM, Montreal, Canada.
- 700 1_
- $a Hamet, Pavel, $u Montreal University Hospital Research Center, CRCHUM, Montreal, Canada. $d 1943- $7 xx0044620
- 700 1_
- $a Filipovský, Jan, $u 2nd Department of Internal Medicine, Charles University Medical Faculty and Teaching Hospital, Pilsen, Czech Republic. $d 1958- $7 xx0058293
- 700 1_
- $a Kvasnicka, J $u Central Laboratory for Hematology and Thrombotic Centre, First Medical School of Charles University in Prague and General Teaching Hospital, Prague, Czech Republic.
- 700 1_
- $a Cífková, Renata, $u Center for Cardiovascular Prevention, First Medical School of Charles University in Prague and Thomayer Hospital, Czech Republic. $d 1955- $7 nlk20010094490
- 773 0_
- $w MED00009284 $t Atherosclerosis $x 1879-1484 $g Roč. 240, č. 2 (2015), s. 446-452
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/25897999 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20160408 $b ABA008
- 991 __
- $a 20170425101817 $b ABA008
- 999 __
- $a ok $b bmc $g 1113718 $s 934657
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 240 $c 2 $d 446-452 $e 20150411 $i 1879-1484 $m Atherosclerosis $n Atherosclerosis $x MED00009284
- GRA __
- $a NT12102 $p MZ0
- LZP __
- $a Pubmed-20160408
