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Cancer-associated fibroblasts are not formed from cancer cells by epithelial-to-mesenchymal transition in nu/nu mice
B. Dvořánková, K. Smetana, B. Říhová, J. Kučera, R. Mateu, P. Szabo,
Language English Country Germany
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NT13488
MZ0
CEP Register
Digital library NLK
Full text - Article
Source
NLK
ProQuest Central
from 1997-01-01 to 2017-12-31
Medline Complete (EBSCOhost)
from 2000-01-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 1997-01-01 to 2017-12-31
Health & Medicine (ProQuest)
from 1997-01-01 to 2017-12-31
Public Health Database (ProQuest)
from 1997-01-01 to 2017-12-31
- MeSH
- Adenocarcinoma metabolism pathology MeSH
- Cell Lineage * MeSH
- HT29 Cells MeSH
- Stromal Cells metabolism pathology MeSH
- Time Factors MeSH
- Epithelial-Mesenchymal Transition * MeSH
- Fibroblasts metabolism pathology MeSH
- Heterografts MeSH
- Colorectal Neoplasms metabolism pathology MeSH
- Humans MeSH
- Mice, Nude MeSH
- Biomarkers, Tumor metabolism MeSH
- Head and Neck Neoplasms metabolism pathology MeSH
- Pharyngeal Neoplasms metabolism pathology MeSH
- Carcinoma, Squamous Cell metabolism pathology MeSH
- Neoplasm Transplantation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Cancer-associated fibroblasts are bioactive elements influencing the biological properties of malignant tumors. Their origin from different cell types has been established, and the possibility of their formation by epithelial-to-mesenchymal transition from cancer cells is under debate. This study shows that human cancer cells grafted to nu/nu mice induced formation of tumor stroma with the presence of typical smooth muscle actin-containing cancer-associated fibroblasts. These cells seem to be of the host origin because they are not recognized by an antibody specific for human vimentin, as was also verified in vitro. These results suggest that cancer-associated stromal fibroblasts are not formed by epithelial-to-mesenchymal transition from cancer cells.
References provided by Crossref.org
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