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Regulation of human oncogenes' expression by human papillomavirus (HPV) 16 E6 protein

Ana Maria Jimenez Jimenez, Kristyna Cihalova, Dagmar Chudobova, Branislav Ruttkay-Nedecky, Radek Vesely, Vojtech Adam, Rene Kizek

. 2015 ; 2 (1) : 25-29.

Jazyk angličtina Země Česko

Typ dokumentu přehledy, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc16016197

Human papillomavirus (HPV) is a DNA virus from the Papillomaviridae family that is capable of infecting humans. Infection with HPV causes anogenital neoplastic lesions in men and in women. HPV is transmitted by sexual contact generally by asymptomatic carriers. These viruses establish productive infections only in keratinocytes of the skin or mucous membranes. Most HPV infections are subclinical and will cause no physical symptoms; however, in some peoples subclinical infections will become clinical and may cause benign papilloma or cancers, which mainly involve genital regions, and the head and neck areas. In this manuscript, we discuss HPV virology, the molecular mechanisms of carcinogenesis and the regulation of human oncogenes’ expression by E6 HPV 16 protein.

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$a Jimenez Jimenez, Ana Maria $7 xx0301575 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union; Central European Institute of Technology, Brno University of Technology, Czech Republic, European Union
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$a Číhalová, Kristýna $7 xx0260072 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union; Central European Institute of Technology, Brno University of Technology, Czech Republic, European Union
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$a Chudobová, Dagmar $7 _AN075697 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union; Central European Institute of Technology, Brno University of Technology, Czech Republic, European Union
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$a Ruttkay-Nedecký, Branislav $7 xx0237909 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union; Central European Institute of Technology, Brno University of Technology, Czech Republic, European Union
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$a Veselý, Radek, $d 1972- $7 mzk2011673138 $u Department of Traumatology at the Medical Faculty, Masaryk University and Trauma Hospital of Brno, Czech Republic, European Union
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$a Adam, Vojtěch, $d 1982- $7 xx0064599 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union; Central European Institute of Technology, Brno University of Technology, Czech Republic, European Union
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