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Epidemiology and pathogenesis of Ebola viruses

Petr Michalek, Ludmila Krejcova, Vojtech Adam, Rene Kizek

Language English Country Czech Republic

Document type Review, Research Support, Non-U.S. Gov't

The family Filoviridae consists of three genera, the Ebolaviruses, Marburgviruses, and the recently described Cuevaviruses. The two first of them belong among the most virulent viruses. The Ebola viruses, respectively Zaire species of this genera is the causative agent of the biggest ebola outbreak, namely West Africa Ebola Outbreak, which started in 2014, and in which the case-mortality rate has been reported to be at about 50 percent, with the number of total cases exceeding twenty-four thousands[1]. In comparison with earlier Ebola outbreaks mortality have been higher (80 - 90 percent), but number of cases was a thousand times lower. In this study will be presented epidemiology and pathogenesis of Ebola virus disease including new findings resulting from the studies linked with 2014 Ebola Outbreak in West Africa. The EVD epidemiology, pathogenesis, and clinical characterization will be discussed in this study.

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$a Michálek, Petr $7 _AN082249 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union
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$a Epidemiology and pathogenesis of Ebola viruses / $c Petr Michalek, Ludmila Krejcova, Vojtech Adam, Rene Kizek
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$a The family Filoviridae consists of three genera, the Ebolaviruses, Marburgviruses, and the recently described Cuevaviruses. The two first of them belong among the most virulent viruses. The Ebola viruses, respectively Zaire species of this genera is the causative agent of the biggest ebola outbreak, namely West Africa Ebola Outbreak, which started in 2014, and in which the case-mortality rate has been reported to be at about 50 percent, with the number of total cases exceeding twenty-four thousands[1]. In comparison with earlier Ebola outbreaks mortality have been higher (80 - 90 percent), but number of cases was a thousand times lower. In this study will be presented epidemiology and pathogenesis of Ebola virus disease including new findings resulting from the studies linked with 2014 Ebola Outbreak in West Africa. The EVD epidemiology, pathogenesis, and clinical characterization will be discussed in this study.
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$a Krejčová, Ludmila $7 _AN074759 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union
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$a Adam, Vojtěch, $d 1982- $7 xx0064599 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union; Central European Institute of Technology, Brno University of Technology, Czech Republic, European Union
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$a Kizek, René, $d 1972- $7 jn20001005291 $u Department of Chemistry and Biochemistry, Mendel University in Brno, Czech Republic, European Union; Central European Institute of Technology, Brno University of Technology, Czech Republic, European Union
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