-
Je něco špatně v tomto záznamu ?
Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis
LA. Cerezo, M. Kuklová, H. Hulejová, Z. Vernerová, N. Kaspříková, D. Veigl, K. Pavelka, J. Vencovský, L. Šenolt,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 1992
Free Medical Journals
od 1992
PubMed Central
od 1992
Europe PubMed Central
od 1992
ProQuest Central
od 2014-01-01
Open Access Digital Library
od 1992-01-01
Open Access Digital Library
od 1992-01-01
Open Access Digital Library
od 1992-01-01
Medline Complete (EBSCOhost)
od 1997-02-01
Health & Medicine (ProQuest)
od 2014-01-01
Wiley-Blackwell Open Access Titles
od 1992
ROAD: Directory of Open Access Scholarly Resources
od 1992
PubMed
26339140
DOI
10.1155/2015/740357
Knihovny.cz E-zdroje
- MeSH
- C-reaktivní protein metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mezibuněčné signální peptidy a proteiny metabolismus MeSH
- revmatoidní artritida metabolismus patologie MeSH
- senioři MeSH
- synoviální membrána metabolismus MeSH
- synoviální tekutina metabolismus MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVE: Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS: PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied. RESULTS: Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001). Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (r = 0.327, P = 0.049) and HAQ score (r = 0.323, P = 0.032), while synovial fluid PGRN correlated only with HAQ (r = 0.310, P = 0.043) in patients with RA. PGRN levels were not associated with CRP or autoantibodies. CONCLUSIONS: This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16020326
- 003
- CZ-PrNML
- 005
- 20160727122137.0
- 007
- ta
- 008
- 160722s2015 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1155/2015/740357 $2 doi
- 024 7_
- $a 10.1155/2015/740357 $2 doi
- 035 __
- $a (PubMed)26339140
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Cerezo, Lucie Andrés $u Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic.
- 245 10
- $a Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis / $c LA. Cerezo, M. Kuklová, H. Hulejová, Z. Vernerová, N. Kaspříková, D. Veigl, K. Pavelka, J. Vencovský, L. Šenolt,
- 520 9_
- $a OBJECTIVE: Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS: PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical analysis of PGRN in synovial tissues was performed. The association between PGRN and C-reactive protein (CRP), disease activity score (DAS28-CRP), and health assessment questionnaire (HAQ) was studied. RESULTS: Circulating PGRN was elevated in patients with RA and OA compared to healthy controls (227.1 ± 100.2 and 221.5 ± 102.5 versus 128.1 ± 34.7 ng/mL; P < 0.001). Synovial fluid levels of PGRN were higher in patients with RA compared to OA (384.5 ± 275.3 versus 241.4 ± 165.2 ng/mL; P = 0.002). PGRN expression was significantly upregulated in the synovial tissue of RA patients particularly in the inflammatory infiltrates. Serum PGRN levels correlated with DAS28 (r = 0.327, P = 0.049) and HAQ score (r = 0.323, P = 0.032), while synovial fluid PGRN correlated only with HAQ (r = 0.310, P = 0.043) in patients with RA. PGRN levels were not associated with CRP or autoantibodies. CONCLUSIONS: This study demonstrates increased PGRN expression at local sites of inflammation and association between PGRN levels, disease activity, and functional impairment in patients with RA.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a revmatoidní artritida $x metabolismus $x patologie $7 D001172
- 650 _2
- $a C-reaktivní protein $x metabolismus $7 D002097
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mezibuněčné signální peptidy a proteiny $x metabolismus $7 D036341
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a synoviální tekutina $x metabolismus $7 D013582
- 650 _2
- $a synoviální membrána $x metabolismus $7 D013583
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Kuklová, Markéta $u Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic.
- 700 1_
- $a Hulejová, Hana $u Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic.
- 700 1_
- $a Vernerová, Zdeňka $u Department of Pathology, Third Faculty of Medicine, Charles University, Šrobárova 50, 100 34 Prague 10, Czech Republic.
- 700 1_
- $a Kaspříková, Nikola $u Institute of Biophysics and Informatics, First Faculty of Medicine, Charles University, Salmovská 1, 120 00 Prague 2, Czech Republic.
- 700 1_
- $a Veigl, David $u First Orthopaedic Clinic, First Faculty of Medicine, Charles University, V Úvalu 84, 150 06 Prague 5, Czech Republic.
- 700 1_
- $a Pavelka, Karel $u Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic ; Department of Rheumatology, First Faculty of Medicine, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic.
- 700 1_
- $a Vencovský, Jiří $u Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic ; Department of Rheumatology, First Faculty of Medicine, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic.
- 700 1_
- $a Šenolt, Ladislav $u Institute of Rheumatology, Na Slupi 4, 12850 Prague 2, Czech Republic ; Department of Rheumatology, First Faculty of Medicine, Charles University, Na Slupi 4, 128 50 Prague 2, Czech Republic.
- 773 0_
- $w MED00006378 $t Mediators of inflammation $x 1466-1861 $g Roč. 2015, č. - (2015), s. 740357
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26339140 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20160722 $b ABA008
- 991 __
- $a 20160727122358 $b ABA008
- 999 __
- $a ok $b bmc $g 1154996 $s 944854
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 2015 $c - $d 740357 $e 20150803 $i 1466-1861 $m Mediators of inflammation $n Mediators Inflamm $x MED00006378
- LZP __
- $a Pubmed-20160722
