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Uterine smooth muscle tumor analysis by comparative genomic hybridization: a useful diagnostic tool in challenging lesions
S. Croce, A. Ribeiro, C. Brulard, JC. Noel, F. Amant, E. Stoeckle, M. Devouassoux-Shisheborah, A. Floquet, L. Arnould, F. Guyon, F. Mishellany, D. Garbay, T. Cuppens, M. Zikan, A. Leroux, E. Frouin, P. Duvillard, P. Terrier, I. Farre, I. Valo,...
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 2000 to 1 year ago
ProQuest Central
from 2000-01-01 to 2022-12-31
Open Access Digital Library
from 2000-01-01
Nursing & Allied Health Database (ProQuest)
from 2000-01-01 to 2022-12-31
Health & Medicine (ProQuest)
from 2000-01-01 to 2022-12-31
ROAD: Directory of Open Access Scholarly Resources
from 1988
- MeSH
- Adult MeSH
- Leiomyoma diagnosis genetics pathology MeSH
- Middle Aged MeSH
- Humans MeSH
- Neoplasm Recurrence, Local genetics pathology MeSH
- Young Adult MeSH
- Smooth Muscle Tumor diagnosis genetics pathology MeSH
- Uterine Neoplasms diagnosis genetics pathology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Comparative Genomic Hybridization MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The diagnosis and management of uterine smooth muscle tumors with uncertain malignant potential (STUMP) is often challenging, and genomic data on these lesions as well as on uterine smooth muscle lesions are limited. We tested the hypothesis that genomic profile determination by array-CGH could split STUMP into a benign group with scarce chromosomal alterations akin to leiomyoma and a malignant group with high chromosomal instability akin to leiomyosarcoma. Array-CGH genomic profile analysis was conducted for a series of 29 cases of uterine STUMP. A group of ten uterine leiomyomas and ten uterine leiomyosarcomas served as controls. The mean age was 50 years (range, 24-85) and the follow-up ranged from 12 to 156 months (average 70 months). Since STUMP is a heterogenous group of tumors with genomic profiles that can harbor few to many chromosomal alterations, we compared genomic indices in leiomyomas and leiomyosarcomas and set a genomic index=10 threshold. Tumors with a genomic index <10 were classified as nonrecurring STUMPs and those with a genomic index >10 represented STUMPs with recurrences and unfavorable outcomes. Hence, the genomic index threshold splits the STUMP category into two groups of tumors with different outcomes: a group comparable to leiomyomas and another similar to leiomyosarcomas, but more indolent. In our STUMP series, genomic analysis by array-CGH is an innovative diagnostic tool for problematic smooth muscle uterine lesions, complementary to the morphological evaluation approach. We provide an improved classification method for distinguishing truly malignant tumors from benign lesions within the category of STUMP, especially those with equivocal morphological features.
Department of Biopathology Institut Bergonié Comprehensive Cancer Centre Bordeaux France
Department of Medical Oncology Institut Bergonié Comprehensive Cancer Centre Bordeaux France
Department of Pathology Centre Jean Perrin Comprehensive Cancer Centre Clermont Ferrand France
Department of Pathology Centre JF Leclerc Comprehensive Cancer Centre Dijon France
Department of Pathology Centre Oscar Lambret Comprehensive Cancer Centre Lille France
Department of Pathology Hôpital de la Croix Rousse Lyon France
Department of Pathology ICO Paul Papin Comprehensive Cancer Centre Angers France
Department of Pathology Institut Gustave Roussy Comprehensive Cancer Centre Villejuif France
Department of Pathology University Hospital Montpellier France
Department of Surgery Institut Bergonié Comprehensive Cancer Centre Bordeaux France
References provided by Crossref.org
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- $a Croce, Sabrina $u 1] Department of Biopathology, Institut Bergonié, Comprehensive Cancer Centre, Bordeaux, France [2] Institut National de la Santé et de la Recherche Medicale (INSERM) U916, Bordeaux, France.
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- $a The diagnosis and management of uterine smooth muscle tumors with uncertain malignant potential (STUMP) is often challenging, and genomic data on these lesions as well as on uterine smooth muscle lesions are limited. We tested the hypothesis that genomic profile determination by array-CGH could split STUMP into a benign group with scarce chromosomal alterations akin to leiomyoma and a malignant group with high chromosomal instability akin to leiomyosarcoma. Array-CGH genomic profile analysis was conducted for a series of 29 cases of uterine STUMP. A group of ten uterine leiomyomas and ten uterine leiomyosarcomas served as controls. The mean age was 50 years (range, 24-85) and the follow-up ranged from 12 to 156 months (average 70 months). Since STUMP is a heterogenous group of tumors with genomic profiles that can harbor few to many chromosomal alterations, we compared genomic indices in leiomyomas and leiomyosarcomas and set a genomic index=10 threshold. Tumors with a genomic index <10 were classified as nonrecurring STUMPs and those with a genomic index >10 represented STUMPs with recurrences and unfavorable outcomes. Hence, the genomic index threshold splits the STUMP category into two groups of tumors with different outcomes: a group comparable to leiomyomas and another similar to leiomyosarcomas, but more indolent. In our STUMP series, genomic analysis by array-CGH is an innovative diagnostic tool for problematic smooth muscle uterine lesions, complementary to the morphological evaluation approach. We provide an improved classification method for distinguishing truly malignant tumors from benign lesions within the category of STUMP, especially those with equivocal morphological features.
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