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Cost-effectiveness of Tyrosine Kinase Inhibitor Treatment Strategies for Chronic Myeloid Leukemia in Chronic Phase After Generic Entry of Imatinib in the United States
WV. Padula, RA. Larson, SB. Dusetzina, JF. Apperley, R. Hehlmann, M. Baccarani, E. Eigendorff, J. Guilhot, F. Guilhot, R. Hehlmann, FX. Mahon, G. Martinelli, J. Mayer, MC. Müller, D. Niederwieser, S. Saussele, CA. Schiffer, RT. Silver, B....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu srovnávací studie, časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Odkazy
PubMed
26944912
DOI
10.1093/jnci/djw003
Knihovny.cz E-zdroje
- MeSH
- analýza nákladů a výnosů MeSH
- analýza přežití MeSH
- antitumorózní látky ekonomika terapeutické užití MeSH
- chronická myeloidní leukemie farmakoterapie ekonomika mortalita MeSH
- dospělí MeSH
- ekonometrické modely MeSH
- generika * ekonomika terapeutické užití MeSH
- imatinib mesylát ekonomika terapeutické užití MeSH
- inhibitory proteinkinas ekonomika terapeutické užití MeSH
- kvalitativně upravené roky života MeSH
- lékařská praxe - způsoby provádění * normy trendy MeSH
- lidé středního věku MeSH
- lidé MeSH
- Markovovy řetězce MeSH
- senioři MeSH
- tyrosinkinasy antagonisté a inhibitory MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- srovnávací studie MeSH
- Geografické názvy
- Spojené státy americké MeSH
BACKGROUND: We analyzed the cost-effectiveness of treating incident chronic myeloid leukemia in chronic phase (CML-CP) with generic imatinib when it becomes available in United States in 2016. In the year following generic entry, imatinib's price is expected to drop 70% to 90%. We hypothesized that initiating treatment with generic imatinib in these patients and then switching to the other tyrosine-kinase inhibitors (TKIs), dasatinib or nilotinib, because of intolerance or lack of effectiveness ("imatinib-first") would be cost-effective compared with the current standard of care: "physicians' choice" of initiating treatment with any one of the three TKIs. METHODS: We constructed Markov models to compare the five-year cost-effectiveness of imatinib-first vs physician's choice from a US commercial payer perspective, assuming 3% annual discounting ($US 2013). The models' clinical endpoint was five-year overall survival taken from a systematic review of clinical trial results. Per-person spending on incident CML-CP treatment overall care components was estimated using Truven's MarketScan claims data. The main outcome of the models was cost per quality-adjusted life-year (QALY). We interpreted outcomes based on a willingness-to-pay threshold of $100 000/QALY. A panel of European LeukemiaNet experts oversaw the study's conduct. RESULTS: Both strategies met the threshold. Imatinib-first ($277 401, 3.87 QALYs) offered patients a 0.10 decrement in QALYs at a savings of $88 343 over five years to payers compared with physician's choice ($365 744, 3.97 QALYs). The imatinib-first incremental cost-effectiveness ratio was approximately $883 730/QALY. The results were robust to multiple sensitivity analyses. CONCLUSION: When imatinib loses patent protection and its price declines, its use will be the cost-effective initial treatment strategy for CML-CP.
Barbara Ann Karmanos Cancer Institute Wayne State University Detroit MI
Department of Haematology and Oncology University Hospital Jena Germany
Department of Haematology Hammersmith Hospital Imperial College London UK
Department of Health Policy and Management Johns Hopkins University Baltimore MD
Department of Hematology and Oncology University Hospital Leipzig Leipzig Germany
Department of Internal Medicine Hematology and Oncology University Hospital Brno Brno Czech Republic
Department of Medicine University of Chicago Chicago IL
Department of Medicine University of Heidelberg Mannheim Germany
Department of Medicine Weill Cornell Medical Center New York NY
INSERM Centre d'Investigation Clinique
Laboratoire d'Hematologie Universite Victor Segalen Bordeaux Pessac France
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- $a Padula, William V $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 245 10
- $a Cost-effectiveness of Tyrosine Kinase Inhibitor Treatment Strategies for Chronic Myeloid Leukemia in Chronic Phase After Generic Entry of Imatinib in the United States / $c WV. Padula, RA. Larson, SB. Dusetzina, JF. Apperley, R. Hehlmann, M. Baccarani, E. Eigendorff, J. Guilhot, F. Guilhot, R. Hehlmann, FX. Mahon, G. Martinelli, J. Mayer, MC. Müller, D. Niederwieser, S. Saussele, CA. Schiffer, RT. Silver, B. Simonsson, RM. Conti,
- 520 9_
- $a BACKGROUND: We analyzed the cost-effectiveness of treating incident chronic myeloid leukemia in chronic phase (CML-CP) with generic imatinib when it becomes available in United States in 2016. In the year following generic entry, imatinib's price is expected to drop 70% to 90%. We hypothesized that initiating treatment with generic imatinib in these patients and then switching to the other tyrosine-kinase inhibitors (TKIs), dasatinib or nilotinib, because of intolerance or lack of effectiveness ("imatinib-first") would be cost-effective compared with the current standard of care: "physicians' choice" of initiating treatment with any one of the three TKIs. METHODS: We constructed Markov models to compare the five-year cost-effectiveness of imatinib-first vs physician's choice from a US commercial payer perspective, assuming 3% annual discounting ($US 2013). The models' clinical endpoint was five-year overall survival taken from a systematic review of clinical trial results. Per-person spending on incident CML-CP treatment overall care components was estimated using Truven's MarketScan claims data. The main outcome of the models was cost per quality-adjusted life-year (QALY). We interpreted outcomes based on a willingness-to-pay threshold of $100 000/QALY. A panel of European LeukemiaNet experts oversaw the study's conduct. RESULTS: Both strategies met the threshold. Imatinib-first ($277 401, 3.87 QALYs) offered patients a 0.10 decrement in QALYs at a savings of $88 343 over five years to payers compared with physician's choice ($365 744, 3.97 QALYs). The imatinib-first incremental cost-effectiveness ratio was approximately $883 730/QALY. The results were robust to multiple sensitivity analyses. CONCLUSION: When imatinib loses patent protection and its price declines, its use will be the cost-effective initial treatment strategy for CML-CP.
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- 700 1_
- $a Larson, Richard A $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Dusetzina, Stacie B $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Apperley, Jane F $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS). $7 gn_A_00007843
- 700 1_
- $a Hehlmann, Rudiger $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Baccarani, Michele $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Eigendorff, Ekkehard $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Guilhot, Joelle $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Guilhot, Francois $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Hehlmann, Rüdiger, $d 1941- $7 xx0110206 $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Mahon, Francois-Xavier $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Martinelli, Giovanni $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Mayer, Jiri $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Müller, Martin C $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Niederwieser, Dietger $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Saussele, Susanne $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Schiffer, Charles A $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Silver, Richard T $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Simonsson, Bengt $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS).
- 700 1_
- $a Conti, Rena M $u Department of Health Policy and Management, Johns Hopkins University, Baltimore, MD (WVP); Department of Medicine (RAL) and Departments of Pediatrics and of Public Health Sciences (RMC), University of Chicago, Chicago, IL; Eshelman School of Pharmacy and Gillings School of Global Public Health, Lineberger Comprehensive Cancer Center, and Cecil G. Sheps Center for Health Services Research, University of North Carolina, Chapel Hill, NC (SBD); Department of Haematology, Hammersmith Hospital, Imperial College, London, UK (JFA); Department of Medicine (RH, SS) and Department of Hematology and Oncology (MCM), University of Heidelberg, Mannheim, Germany; Department of Haematology and Oncology, S. Orsola-Malpighi University Hospital (MB), and Department of Hematology, "L. e A. Seragnoli" (GM), University of Bologna, Bologna, Italy; Department of Haematology and Oncology, University Hospital, Jena, Germany (EE); INSERM Centre d'Investigation Clinique (CIC) 1402, CHU de Poitiers, Poitiers, France (JG, FG); Laboratoire d'Hematologie, Universite Victor Segalen, Bordeaux, Pessac, France (FXM); Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic (JM); Department of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany (DN); Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI (CAS); Department of Medicine, Weill Cornell Medical Center, New York, NY (RTS); Uppsala University, Uppsala, Sweden (BS). rconti@peds.bsd.uchicago.edu.
- 773 0_
- $w MED00003002 $t Journal of the National Cancer Institute $x 1460-2105 $g Roč. 108, č. 7 (2016)
- 856 41
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