• Something wrong with this record ?

TDM1 Regulation Determines the Number of Meiotic Divisions

M. Cifuentes, S. Jolivet, L. Cromer, H. Harashima, P. Bulankova, C. Renne, W. Crismani, Y. Nomura, H. Nakagami, K. Sugimoto, A. Schnittger, K. Riha, R. Mercier,

. 2016 ; 12 (2) : e1005856. [pub] 20160212

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc16027673

Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division are poorly understood. We show here that Arabidopsis thaliana TDM1, which has been previously shown to be essential for meiotic termination, interacts directly with the Anaphase-Promoting Complex. Further, mutations in TDM1 in a conserved putative Cyclin-Dependant Kinase (CDK) phosphorylation site (T16-P17) dominantly provoked premature meiosis termination after the first division, and the production of diploid spores and gametes. The CDKA;1-CYCA1.2/TAM complex, which is required to prevent premature meiotic exit, phosphorylated TDM1 at T16 in vitro. Finally, while CYCA1;2/TAM was previously shown to be expressed only at meiosis I, TDM1 is present throughout meiosis. These data, together with epistasis analysis, lead us to propose that TDM1 is an APC/C component whose function is to ensure meiosis termination at the end of meiosis II, and whose activity is inhibited at meiosis I by CDKA;1-TAM-mediated phosphorylation to prevent premature meiotic exit. This provides a molecular mechanism for the differential decision of performing an additional round of division, or not, at the end of meiosis I and II, respectively.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc16027673
003      
CZ-PrNML
005      
20161031124425.0
007      
ta
008      
161005s2016 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1371/journal.pgen.1005856 $2 doi
024    7_
$a 10.1371/journal.pgen.1005856 $2 doi
035    __
$a (PubMed)26871453
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Cifuentes, Marta $u Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026 Versailles Cedex, France.
245    10
$a TDM1 Regulation Determines the Number of Meiotic Divisions / $c M. Cifuentes, S. Jolivet, L. Cromer, H. Harashima, P. Bulankova, C. Renne, W. Crismani, Y. Nomura, H. Nakagami, K. Sugimoto, A. Schnittger, K. Riha, R. Mercier,
520    9_
$a Cell cycle control must be modified at meiosis to allow two divisions to follow a single round of DNA replication, resulting in ploidy reduction. The mechanisms that ensure meiosis termination at the end of the second and not at the end of first division are poorly understood. We show here that Arabidopsis thaliana TDM1, which has been previously shown to be essential for meiotic termination, interacts directly with the Anaphase-Promoting Complex. Further, mutations in TDM1 in a conserved putative Cyclin-Dependant Kinase (CDK) phosphorylation site (T16-P17) dominantly provoked premature meiosis termination after the first division, and the production of diploid spores and gametes. The CDKA;1-CYCA1.2/TAM complex, which is required to prevent premature meiotic exit, phosphorylated TDM1 at T16 in vitro. Finally, while CYCA1;2/TAM was previously shown to be expressed only at meiosis I, TDM1 is present throughout meiosis. These data, together with epistasis analysis, lead us to propose that TDM1 is an APC/C component whose function is to ensure meiosis termination at the end of meiosis II, and whose activity is inhibited at meiosis I by CDKA;1-TAM-mediated phosphorylation to prevent premature meiotic exit. This provides a molecular mechanism for the differential decision of performing an additional round of division, or not, at the end of meiosis I and II, respectively.
650    _2
$a anafázi podporující komplex $x metabolismus $7 D064173
650    _2
$a Arabidopsis $x cytologie $x genetika $7 D017360
650    _2
$a proteiny huseníčku $x genetika $x metabolismus $7 D029681
650    _2
$a chromozomy rostlin $x genetika $7 D032461
650    _2
$a cykliny $x genetika $x metabolismus $7 D016213
650    _2
$a genetická epistáze $7 D004843
650    _2
$a dominantní geny $7 D005799
650    _2
$a genetické testování $7 D005820
650    12
$a meióza $7 D008540
650    _2
$a biologické modely $7 D008954
650    _2
$a mutace $x genetika $7 D009154
650    _2
$a fosforylace $7 D010766
650    _2
$a fosfothreonin $x metabolismus $7 D010769
650    _2
$a vazba proteinů $7 D011485
650    _2
$a podjednotky proteinů $x metabolismus $7 D021122
650    _2
$a tetraploidie $7 D057891
650    _2
$a tubulin $x metabolismus $7 D014404
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Jolivet, Sylvie $u Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026 Versailles Cedex, France.
700    1_
$a Cromer, Laurence $u Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026 Versailles Cedex, France.
700    1_
$a Harashima, Hirofumi $u RIKEN Center for Sustainable Resource Science, Suehiro, Tsurumi, Yokohama, Japan.
700    1_
$a Bulankova, Petra $u Gregor Mendel Institute, Austrian Academy of Sciences, Vienna, Austria.
700    1_
$a Renne, Charlotte $u Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026 Versailles Cedex, France.
700    1_
$a Crismani, Wayne $u Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026 Versailles Cedex, France.
700    1_
$a Nomura, Yuko $u RIKEN Center for Sustainable Resource Science, Suehiro, Tsurumi, Yokohama, Japan.
700    1_
$a Nakagami, Hirofumi $u RIKEN Center for Sustainable Resource Science, Suehiro, Tsurumi, Yokohama, Japan.
700    1_
$a Sugimoto, Keiko $u RIKEN Center for Sustainable Resource Science, Suehiro, Tsurumi, Yokohama, Japan.
700    1_
$a Schnittger, Arp $u University of Hamburg, Biozentrum Klein Flottbek, Department of Developmental Biology, Hamburg, Germany.
700    1_
$a Riha, Karel $u Gregor Mendel Institute, Austrian Academy of Sciences, Vienna, Austria. Central European Institute of Technology (CEITEC), Masaryk University, Kamenice, Brno, Czech Republic.
700    1_
$a Mercier, Raphael $u Institut Jean-Pierre Bourgin, INRA, AgroParisTech, CNRS, Université Paris-Saclay, RD10, 78026 Versailles Cedex, France.
773    0_
$w MED00008920 $t PLoS genetics $x 1553-7404 $g Roč. 12, č. 2 (2016), s. e1005856
856    41
$u https://pubmed.ncbi.nlm.nih.gov/26871453 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20161005 $b ABA008
991    __
$a 20161031124349 $b ABA008
999    __
$a ok $b bmc $g 1165987 $s 952303
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 12 $c 2 $d e1005856 $e 20160212 $i 1553-7404 $m PLoS genetics $n PLoS Genet $x MED00008920
LZP    __
$a Pubmed-20161005

Find record

Citation metrics

Archiving options