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Cancer prevention and therapy through the modulation of the tumor microenvironment
SC. Casey, A. Amedei, K. Aquilano, AS. Azmi, F. Benencia, D. Bhakta, AE. Bilsland, CS. Boosani, S. Chen, MR. Ciriolo, S. Crawford, H. Fujii, AG. Georgakilas, G. Guha, D. Halicka, WG. Helferich, P. Heneberg, K. Honoki, WN. Keith, SP. Kerkar, SI....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, práce podpořená grantem, přehledy
Grantová podpora
NT13663
MZ0
CEP - Centrální evidence projektů
- MeSH
- cílená molekulární terapie MeSH
- karcinogeneze účinky léků genetika MeSH
- lidé MeSH
- nádorové mikroprostředí účinky léků genetika MeSH
- nádory farmakoterapie genetika prevence a kontrola MeSH
- patologická angiogeneze farmakoterapie genetika prevence a kontrola MeSH
- proliferace buněk účinky léků MeSH
- protinádorové látky terapeutické užití MeSH
- signální transdukce MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, N.I.H., Intramural MeSH
Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve dynamically through indirect and direct cellular interactions, eliciting multiscale effects on many biological programs, including cellular proliferation, growth, and metabolism, as well as angiogenesis and hypoxia and innate and adaptive immunity. Here we highlight specific biological processes that could be exploited as targets for the prevention and therapy of cancer. Specifically, we describe how inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted. We have also identified therapeutic agents as approaches, in particular natural products such as berberine, resveratrol, onionin A, epigallocatechin gallate, genistein, curcumin, naringenin, desoxyrhapontigenin, piperine, and zerumbone, that may warrant further investigation to target the tumor microenvironment for the treatment and/or prevention of cancer.
Charles University Prague 3rd Faculty of Medicine Prague Czech Republic
Department of Biology Southern Connecticut State University New Haven CT United States
Department of Biology University of Rome Tor Vergata Rome Italy
Department of Biomedical Sciences Ohio University Athens OH United States
Department of Biomedical Sciences School of Medicine Creighton University Omaha NE United States
Department of Clinical Pharmacy and Therapeutics Applied Science University Amman Jordan
Department of Environmental Sciences Faculty of Agriculture Dalhousie University Nova Scotia Canada
Department of Experimental and Clinical Medicine University of Florence Florence Italy
Department of Oncology Wayne State University School of Medicine Detroit MI United States
Department of Orthopedic Surgery Nara Medical University Kashihara Japan
Division of Urology Sunnybrook Health Sciences Centre Toronto Ontario Canada
Institute of Cancer Sciences University of Glasgow Glasgow United Kingdom
Mount Sinai Roosevelt Hospital Icahn Mount Sinai School of Medicine New York City NY United States
New York Medical College Valhalla NY United States
Ovarian and Prostate Cancer Research Laboratory Guildford Surrey United Kingdom
Sanus Biosciences San Diego United States
School of Chemical and Biotechnology SASTRA University Thanjavur 613401 Tamil Nadu India
University of Florence Florence Italy
University of Illinois at Urbana Champaign Champaign Urbana IL United States
Citace poskytuje Crossref.org
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