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Biotherapies of rabbit serum modulate the immune response and decrease parasite load in mice infected with Trypanosoma cruzi
Fabiana Nabarro Ferraz, Franciele Karina da Veiga, Denise Lessa Aleixo, Larissa Ciupa, Benício Alves de Abreu Filho, Suelen Santos da Silva, Ivete Conchon-Costa, Wander Rogério Pavanelli, Silvana Marques de Araújo
Jazyk angličtina Země Česko
Typ dokumentu randomizované kontrolované studie, práce podpořená grantem
- MeSH
- antiparazitární látky farmakologie terapeutické užití MeSH
- biologická terapie MeSH
- biologické přípravky farmakologie terapeutické užití MeSH
- Chagasova nemoc * farmakoterapie imunologie parazitologie patologie MeSH
- cytokiny krev MeSH
- homeopatie * MeSH
- interleukin-17 krev MeSH
- interleukin-4 krev MeSH
- modely nemocí na zvířatech MeSH
- myši MeSH
- parazitemie farmakoterapie MeSH
- srdce parazitologie MeSH
- Trypanosoma cruzi * MeSH
- zánět krev MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
The use of biotherapies as intervention in murine infection with Trypanosoma cruzi is a possible means to understand the effects of these highly diluted medications. This study evaluated the effects of biotherapies that were prepared from rabbit serum uninfected (BSNI13c group) and chronically infected with Y strain of T. cruzi (BSI13c group), dynamization 13c, in mice experimentally infected. Parasitological, histopathological, and immunological parameters were evaluated. BSNI13c group exhibited the best outcome, including decreases in parasitemia and parasite load/inflammation in the heart, with pronounced Th1 response on days 8 and 12 after infection (a.i.) that was attributable to decrease in IL-4 concentrations, with no increases in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. In contrast, BSI13c group did not exhibit alterations in parasitemia but a significant decrease in parasite load/inflammation in the heart, with pronounced Th2 response on day 12 a.i. that was attributable to increase in IL-4 concentrations, with no changes in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. This study suggest that biotherapies that were prepared from rabbit serum uninfected and chronically infected with T. cruzi differentially modulate the immune system in mice infected with this protozoan, providing evidence of the actions of these medications.
Citace poskytuje Crossref.org
Literatura
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- $a The use of biotherapies as intervention in murine infection with Trypanosoma cruzi is a possible means to understand the effects of these highly diluted medications. This study evaluated the effects of biotherapies that were prepared from rabbit serum uninfected (BSNI13c group) and chronically infected with Y strain of T. cruzi (BSI13c group), dynamization 13c, in mice experimentally infected. Parasitological, histopathological, and immunological parameters were evaluated. BSNI13c group exhibited the best outcome, including decreases in parasitemia and parasite load/inflammation in the heart, with pronounced Th1 response on days 8 and 12 after infection (a.i.) that was attributable to decrease in IL-4 concentrations, with no increases in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. In contrast, BSI13c group did not exhibit alterations in parasitemia but a significant decrease in parasite load/inflammation in the heart, with pronounced Th2 response on day 12 a.i. that was attributable to increase in IL-4 concentrations, with no changes in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. This study suggest that biotherapies that were prepared from rabbit serum uninfected and chronically infected with T. cruzi differentially modulate the immune system in mice infected with this protozoan, providing evidence of the actions of these medications.
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