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Biotherapies of rabbit serum modulate the immune response and decrease parasite load in mice infected with Trypanosoma cruzi
Fabiana Nabarro Ferraz, Franciele Karina da Veiga, Denise Lessa Aleixo, Larissa Ciupa, Benício Alves de Abreu Filho, Suelen Santos da Silva, Ivete Conchon-Costa, Wander Rogério Pavanelli, Silvana Marques de Araújo
Language English Country Czech Republic
Document type Randomized Controlled Trial, Research Support, Non-U.S. Gov't
- MeSH
- Antiparasitic Agents pharmacology therapeutic use MeSH
- Biological Therapy MeSH
- Biological Products pharmacology therapeutic use MeSH
- Chagas Disease * drug therapy immunology parasitology pathology MeSH
- Cytokines blood MeSH
- Homeopathy * MeSH
- Interleukin-17 blood MeSH
- Interleukin-4 blood MeSH
- Disease Models, Animal MeSH
- Mice MeSH
- Parasitemia drug therapy MeSH
- Heart parasitology MeSH
- Trypanosoma cruzi * MeSH
- Inflammation blood MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Randomized Controlled Trial MeSH
The use of biotherapies as intervention in murine infection with Trypanosoma cruzi is a possible means to understand the effects of these highly diluted medications. This study evaluated the effects of biotherapies that were prepared from rabbit serum uninfected (BSNI13c group) and chronically infected with Y strain of T. cruzi (BSI13c group), dynamization 13c, in mice experimentally infected. Parasitological, histopathological, and immunological parameters were evaluated. BSNI13c group exhibited the best outcome, including decreases in parasitemia and parasite load/inflammation in the heart, with pronounced Th1 response on days 8 and 12 after infection (a.i.) that was attributable to decrease in IL-4 concentrations, with no increases in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. In contrast, BSI13c group did not exhibit alterations in parasitemia but a significant decrease in parasite load/inflammation in the heart, with pronounced Th2 response on day 12 a.i. that was attributable to increase in IL-4 concentrations, with no changes in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. This study suggest that biotherapies that were prepared from rabbit serum uninfected and chronically infected with T. cruzi differentially modulate the immune system in mice infected with this protozoan, providing evidence of the actions of these medications.
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Literatura
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- $a The use of biotherapies as intervention in murine infection with Trypanosoma cruzi is a possible means to understand the effects of these highly diluted medications. This study evaluated the effects of biotherapies that were prepared from rabbit serum uninfected (BSNI13c group) and chronically infected with Y strain of T. cruzi (BSI13c group), dynamization 13c, in mice experimentally infected. Parasitological, histopathological, and immunological parameters were evaluated. BSNI13c group exhibited the best outcome, including decreases in parasitemia and parasite load/inflammation in the heart, with pronounced Th1 response on days 8 and 12 after infection (a.i.) that was attributable to decrease in IL-4 concentrations, with no increases in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. In contrast, BSI13c group did not exhibit alterations in parasitemia but a significant decrease in parasite load/inflammation in the heart, with pronounced Th2 response on day 12 a.i. that was attributable to increase in IL-4 concentrations, with no changes in TNF-α and IFN-γ, associated to decrease in IL-17A compared to control. This study suggest that biotherapies that were prepared from rabbit serum uninfected and chronically infected with T. cruzi differentially modulate the immune system in mice infected with this protozoan, providing evidence of the actions of these medications.
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