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Synthesis and evaluation of condensed magnetic nanocrystal clusters with in vivo multispectral optoacoustic tomography for tumour targeting
Y. Sarigiannis, Α. Kolokithas-Ntoukas, N. Beziere, R. Zbořil, E. Papadimitriou, K. Avgoustakis, M. Lamprou, Z. Medrikova, E. Rousalis, V. Ntziachristos, A. Bakandritsos,
Language English Country Netherlands
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Doxorubicin administration & dosage MeSH
- Drug Delivery Systems MeSH
- Magnets chemistry MeSH
- Mice, Nude MeSH
- Mice MeSH
- Breast Neoplasms pathology MeSH
- Nanoparticles analysis chemistry MeSH
- Photoacoustic Techniques methods MeSH
- Tomography, X-Ray Computed methods MeSH
- Polyethylene Glycols chemistry pharmacokinetics MeSH
- Antibiotics, Antineoplastic administration & dosage MeSH
- Breast pathology MeSH
- Ferric Compounds chemistry pharmacokinetics MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Colloidal clusters of magnetic iron oxide nanocrystals (MIONs), particularly in the condensed pattern (co-CNCs), have emerged as new superstructures to improve further the performance of MIONs in applications pertaining to magnetic manipulation (drug delivery) and magnetic resonance imaging (MRI). Exploitation of the advantages they represent and their establishment in the area of nanomedicine demands a particular set of assets. The present work describes the development and evaluation of MION-based co-CNCs featuring for the first time such assets: High magnetization, as well as magnetic content and moment, high relaxivities (r2 = 400 and r2* = 905 s(-1) mMFe(-1)) and intrinsic loss power (2.3 nH m(2) kgFe(-1)) are combined with unprecedented colloidal stability and structural integrity, stealth and drug-loading properties. The reported nanoconstructs are endowed with additional important features such as cost-effective synthesis and storage, prolonged self-life and biocompatibility. It is finally showcased with in vivo multispectral optoacoustic tomography how these properties culminate in a system suitable for targeting breast cancer and for forceful in vivo manipulation with low magnetic field gradients.
Department of Materials Science University of Patras 26504 Rio Greece
Department of Pharmacy University of Patras 26504 Rio Greece
References provided by Crossref.org
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