Colloidal clusters of magnetic iron oxide nanocrystals (MIONs), particularly in the condensed pattern (co-CNCs), have emerged as new superstructures to improve further the performance of MIONs in applications pertaining to magnetic manipulation (drug delivery) and magnetic resonance imaging (MRI). Exploitation of the advantages they represent and their establishment in the area of nanomedicine demands a particular set of assets. The present work describes the development and evaluation of MION-based co-CNCs featuring for the first time such assets: High magnetization, as well as magnetic content and moment, high relaxivities (r2 = 400 and r2* = 905 s(-1) mMFe(-1)) and intrinsic loss power (2.3 nH m(2) kgFe(-1)) are combined with unprecedented colloidal stability and structural integrity, stealth and drug-loading properties. The reported nanoconstructs are endowed with additional important features such as cost-effective synthesis and storage, prolonged self-life and biocompatibility. It is finally showcased with in vivo multispectral optoacoustic tomography how these properties culminate in a system suitable for targeting breast cancer and for forceful in vivo manipulation with low magnetic field gradients.

Department of Materials Science University of Patras 26504 Rio Greece

Department of Materials Science University of Patras 26504 Rio Greece; Regional Centre of Advanced Technologies and Materials Departments of Physical Chemistry and Experimental Physics Faculty of Science Palacky University 783 71 Olomouc Czech Republic

Department of Pharmacy University of Patras 26504 Rio Greece

Institute for Biological and Medical Imaging Helmholtz Zentrum München and Technische Universität München D 85764 Neuherberg Germany

Regional Centre of Advanced Technologies and Materials Departments of Physical Chemistry and Experimental Physics Faculty of Science Palacky University 783 71 Olomouc Czech Republic

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