-
Je něco špatně v tomto záznamu ?
Comparative assessment of the environmental hazards of and exposure to perfluoroalkyl phosphonic and phosphinic acids (PFPAs and PFPiAs): Current knowledge, gaps, challenges and research needs
Z. Wang, IT. Cousins, U. Berger, K. Hungerbühler, M. Scheringer,
Jazyk angličtina Země Nizozemsko
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem, přehledy
- MeSH
- ekotoxikologie MeSH
- fluorokarbony analýza farmakokinetika toxicita MeSH
- hodnocení rizik MeSH
- kyseliny fosfinové analýza farmakokinetika toxicita MeSH
- kyseliny fosforité analýza farmakokinetika toxicita MeSH
- látky znečišťující životní prostředí analýza farmakokinetika toxicita MeSH
- lidé MeSH
- monitorování životního prostředí metody MeSH
- nebezpečné látky analýza farmakokinetika toxicita MeSH
- výzkumný projekt MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- srovnávací studie MeSH
Perfluoroalkyl phosphonic and phosphinic acids (PFPAs and PFPiAs) are sub-groups of per- and polyfluoroalkyl substances (PFASs) that have been commercialized since the 1970s, particularly as defoamers in pesticide formulations and wetting agents in consumer products. Recently, C4/C4 PFPiA and its derivatives have been presented as alternatives to long-chain PFASs in certain applications. In this study, we systematically assess the publicly available information on the hazardous properties, occurrence, and exposure routes of PFPAs and PFPiAs, and make comparisons to the corresponding properties of their better-known carboxylic and sulfonic acid analogs (i.e. PFCAs and PFSAs). This comparative assessment indicates that [i] PFPAs likely have high persistence and long-range transport potential; [ii] PFPiAs may transform to PFPAs (and possibly PFCAs) in the environment and biota; [iii] certain PFPAs and PFPiAs can only be slowly eliminated from rainbow trout and rats, similarly to long-chain PFCAs and PFSAs; [iv] PFPAs and PFPiAs have modes-of-action that are both similar to, and different from, those of PFCAs and PFSAs; and [v] the measured levels of PFPAs/PFPiAs in the global environment and biota appear to be low in comparison to PFCAs and PFSAs, suggesting, for the time being, low risks from PFPAs and PFPiAs alone. Although risks from individual PFPAs/PFPiAs are currently low, their ongoing production and use and high persistence will lead to increasing exposure and risks over time. Furthermore, simultaneous exposure to PFPAs, PFPiAs and other PFASs may result in additive effects necessitating cumulative risk assessments. To facilitate effective future research, we highlight possible strategies to overcome sampling and analytical challenges.
Department Analytical Chemistry Helmholtz Centre for Environmental Research DE 04318 Leipzig Germany
Institute for Chemical and Bioengineering ETH Zurich CH 8093 Zurich Switzerland
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17000398
- 003
- CZ-PrNML
- 005
- 20170116104557.0
- 007
- ta
- 008
- 170103s2016 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.envint.2016.01.023 $2 doi
- 024 7_
- $a 10.1016/j.envint.2016.01.023 $2 doi
- 035 __
- $a (PubMed)26922149
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Wang, Zhanyun $u Institute for Chemical and Bioengineering, ETH Zurich, CH-8093 Zurich, Switzerland. Electronic address: zhanyun.wang@chem.ethz.ch.
- 245 10
- $a Comparative assessment of the environmental hazards of and exposure to perfluoroalkyl phosphonic and phosphinic acids (PFPAs and PFPiAs): Current knowledge, gaps, challenges and research needs / $c Z. Wang, IT. Cousins, U. Berger, K. Hungerbühler, M. Scheringer,
- 520 9_
- $a Perfluoroalkyl phosphonic and phosphinic acids (PFPAs and PFPiAs) are sub-groups of per- and polyfluoroalkyl substances (PFASs) that have been commercialized since the 1970s, particularly as defoamers in pesticide formulations and wetting agents in consumer products. Recently, C4/C4 PFPiA and its derivatives have been presented as alternatives to long-chain PFASs in certain applications. In this study, we systematically assess the publicly available information on the hazardous properties, occurrence, and exposure routes of PFPAs and PFPiAs, and make comparisons to the corresponding properties of their better-known carboxylic and sulfonic acid analogs (i.e. PFCAs and PFSAs). This comparative assessment indicates that [i] PFPAs likely have high persistence and long-range transport potential; [ii] PFPiAs may transform to PFPAs (and possibly PFCAs) in the environment and biota; [iii] certain PFPAs and PFPiAs can only be slowly eliminated from rainbow trout and rats, similarly to long-chain PFCAs and PFSAs; [iv] PFPAs and PFPiAs have modes-of-action that are both similar to, and different from, those of PFCAs and PFSAs; and [v] the measured levels of PFPAs/PFPiAs in the global environment and biota appear to be low in comparison to PFCAs and PFSAs, suggesting, for the time being, low risks from PFPAs and PFPiAs alone. Although risks from individual PFPAs/PFPiAs are currently low, their ongoing production and use and high persistence will lead to increasing exposure and risks over time. Furthermore, simultaneous exposure to PFPAs, PFPiAs and other PFASs may result in additive effects necessitating cumulative risk assessments. To facilitate effective future research, we highlight possible strategies to overcome sampling and analytical challenges.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a ekotoxikologie $7 D054750
- 650 _2
- $a monitorování životního prostředí $x metody $7 D004784
- 650 _2
- $a látky znečišťující životní prostředí $x analýza $x farmakokinetika $x toxicita $7 D004785
- 650 _2
- $a fluorokarbony $x analýza $x farmakokinetika $x toxicita $7 D005466
- 650 _2
- $a nebezpečné látky $x analýza $x farmakokinetika $x toxicita $7 D015386
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a kyseliny fosfinové $x analýza $x farmakokinetika $x toxicita $7 D010721
- 650 _2
- $a kyseliny fosforité $x analýza $x farmakokinetika $x toxicita $7 D010757
- 650 _2
- $a výzkumný projekt $7 D012107
- 650 _2
- $a hodnocení rizik $7 D018570
- 655 _2
- $a srovnávací studie $7 D003160
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Cousins, Ian T $u Department of Environmental Science and Analytical Chemistry (ACES), Stockholm University, SE-10691 Stockholm, Sweden.
- 700 1_
- $a Berger, Urs $u Department Analytical Chemistry, Helmholtz Centre for Environmental Research (UFZ), DE-04318 Leipzig, Germany.
- 700 1_
- $a Hungerbühler, Konrad $u Institute for Chemical and Bioengineering, ETH Zurich, CH-8093 Zurich, Switzerland.
- 700 1_
- $a Scheringer, Martin $u Institute for Chemical and Bioengineering, ETH Zurich, CH-8093 Zurich, Switzerland; RECETOX, Masaryk University, 625 00 Brno, Czech Republic.
- 773 0_
- $w MED00001541 $t Environment international $x 1873-6750 $g Roč. 89-90, č. - (2016), s. 235-47
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/26922149 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20170103 $b ABA008
- 991 __
- $a 20170116104702 $b ABA008
- 999 __
- $a ok $b bmc $g 1179538 $s 960965
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2016 $b 89-90 $c - $d 235-47 $e 20160226 $i 1873-6750 $m Environment international $n Environ Int $x MED00001541
- LZP __
- $a Pubmed-20170103
