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The role of the endoplasmic reticulum stress in stemness, pluripotency and development

K. Kratochvílová, L. Moráň, S. Paďourová, S. Stejskal, L. Tesařová, P. Šimara, A. Hampl, I. Koutná, P. Vaňhara,

. 2016 ; 95 (3-5) : 115-23. [pub] 20160206

Language English Country Germany

Document type Journal Article, Research Support, Non-U.S. Gov't, Review

Persistent link   https://www.medvik.cz/link/bmc17000420

The molecular machinery of endoplasmic reticulum (ER) integrates various intracellular and extracellular cues to maintain homeostasis in diverse physiological or pathological scenarios. ER stress and the unfolded protein response (UPR) have been found to mediate molecular and biochemical mechanisms that affect cell proliferation, differentiation, and apoptosis. Although a number of reviews on the ER stress response have been published, comprehensive reviews that broadly summarize ER physiology in the context of pluripotency, embryonic development, and tissue homeostasis are lacking. This review complements the current ER literature and provides a summary of the important findings on the role of the ER stress and UPR in embryonic development and pluripotent stem cells.

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$a Paďourová, Stanislava $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
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$a Stejskal, Stanislav $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
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$a Tesařová, Lenka $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
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$a Šimara, Pavel $u Masaryk University, Faculty of Medicine, Department of Histology and Embryology, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
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$a Hampl, Aleš $u Masaryk University, Faculty of Medicine, Department of Histology and Embryology, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.
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$a Koutná, Irena $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic; Centre for Biomedical Image Analysis, Faculty of Informatics, Masaryk University, Brno, Czech Republic.
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$a Vaňhara, Petr $u Masaryk University, Faculty of Medicine, Department of Histology and Embryology, Brno, Czech Republic; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. Electronic address: pvanhara@med.muni.cz.
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