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A Novel Risk Locus at 6p21.3 for Epstein-Barr Virus-Positive Hodgkin Lymphoma
M. Delahaye-Sourdeix, KY. Urayama, V. Gaborieau, R. Veenstra, M. Foll, A. Chabrier, Y. Benavente, A. Nieters, N. Becker, L. Foretova, M. Maynadié, A. Staines, KE. Smedby, I. Glimelius, T. Lightfoot, P. Cocco, P. Galan, LJ. Vatten, EJ. Duell, L....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1991 do Před 1 rokem
Freely Accessible Science Journals
od 1991 do Před 12 měsíci
Open Access Digital Library
od 1991-11-01
Open Access Digital Library
od 1991-11-01
- MeSH
- dospělí MeSH
- genetická predispozice k nemoci MeSH
- hlavní histokompatibilní komplex genetika MeSH
- Hodgkinova nemoc epidemiologie genetika patologie virologie MeSH
- infekce virem Epsteina-Barrové epidemiologie genetika patologie virologie MeSH
- jednonukleotidový polymorfismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- lidské chromozomy, pár 6 * MeSH
- mladiství MeSH
- mladý dospělý MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Nizozemsko epidemiologie MeSH
- Skandinávie a severské státy epidemiologie MeSH
BACKGROUND: A proportion of the genetic variants involved in susceptibility to Hodgkin lymphoma differ by the tumor's Epstein-Barr virus (EBV) status, particularly within the MHC region. METHODS: We have conducted an SNP imputation study of the MHC region, considering tumor EBV status in 1,200 classical Hodgkin lymphoma (cHL) cases and 5,726 control subjects of European origin. Notable findings were genotyped in an independent study population of 468 cHL cases and 551 controls. RESULTS: We identified and subsequently replicated a novel association between a common genetic variant rs6457715 and cHL. Although strongly associated with EBV-positive cHL [OR, 2.33; 95% confidence interval (CI), 1.83-2.97; P = 7 × 10(-12)], there was little evidence for association between rs6457715 and the EBV-negative subgroup of cHL (OR, 1.06; 95% CI, 0.92-1.21), indicating that this association was specific to the EBV-positive subgroup (Phet < P = 10(-8)). Furthermore, the association was limited to EBV-positive cHL subgroups within mixed cell (MCHL) and nodular sclerosis subtypes (NSHL), suggesting that the association is independent of histologic subtype of cHL. CONCLUSIONS: rs6457715, located near the HLA-DPB1 gene, is associated with EBV-positive cHL and suggests this region as a novel susceptibility locus for cHL. IMPACT: This expands the number of genetic variants that are associated with cHL and provides additional evidence for a critical and specific role of EBV in the etiology of this disease.
Centre of Chronic Immunodeficiency Freiburg University Medical Centre Freiburg Freiburg Germany
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Epidemiology Research Statens Serum Institut Copenhagen Denmark
Department of Human Genetics and Disease Diversity Tokyo Medical and Dental University Tokyo Japan
Department of Public Health Occupational Health Section University of Cagliari Cagliari Italy
Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany
Epidemiology and Genetics Unit Department of Health Sciences University of York York United Kingdom
International Agency for Research on Cancer Lyon France
McGill University and Genome Quebec Innovation Centre Montreal Quebec Canada
MRC University of Glasgow Centre for Virus Research University of Glasgow Glasgow United Kingdom
Norwegian University of Science and Technology Trondheim Norway
Radboud University Medical Centre Radboud Institute for Health Sciences Nijmegen the Netherlands
School of Nursing Dublin City University Glasnevin Dublin Ireland
Citace poskytuje Crossref.org
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