-
Je něco špatně v tomto záznamu ?
Biomarkers for the early detection of anthracycline-induced cardiotoxicity: current status
J. M. Horacek, M. Vasatova, R. Pudil, M. Tichy, P. Zak, M. Jakl, L. Jebavy, J. Maly
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Free Medical Journals od 1998
Medline Complete (EBSCOhost) od 2007-06-01
ROAD: Directory of Open Access Scholarly Resources od 2001
Odkazy
PubMed
24457832
DOI
10.5507/bp.2014.004
domovská stránka časopisu
Knihovny.cz E-zdroje
- MeSH
- antibiotika antitumorózní škodlivé účinky MeSH
- antracykliny škodlivé účinky MeSH
- biologické markery analýza MeSH
- kardiotoxicita diagnóza etiologie MeSH
- lidé MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
BACKGROUND: Cardiotoxicity is a well-known and potentially serious complication of anticancer therapy. Anthracycline-based chemotherapy represents the greatest risk. Early detection of cardiotoxicity is crucial for applying preventive and supportive therapeutic strategies. METHODS AND RESULTS: Various methods have been recommended for monitoring of cardiotoxicity. In our conditions, echocardiography and electrocardiography are routinely used. However, this approach shows low sensitivity for the early prediction of cardiomyopathy when the possibilities of appropriate management could still improve the patient's outcome. Recently, biomarkers of cardiac injury have been investigated in the assessment of chemotherapy-induced cardiotoxicity. Cardiospecific biomarkers, such as cardiac troponins, show high diagnostic efficacy in the early subclinical phase of the disease before the clinical onset of cardiomyopathy. Increase in their concentrations correlates with disease severity. As for natriuretic peptides, some studies, including ours, have shown promising results. Definitive evidence of their diagnostic and prognostic role in this context is still lacking and natriuretic peptides have not been routinely used for monitoring of cardiotoxicity in clinical practice. Other perspective biomarkers of cardiotoxicity in oncology are under study, especially heart-type fatty acid-binding protein (H-FABP) and glycogen phosphorylase BB (GPBB). Our studies using GPBB have provided encouraging results. However, the available data are limited and their practical use in this context cannot be recommended until their clinical efficacy is clearly defined. CONCLUSIONS: This review covers the current status of biomarkers for the early detection of anthracycline-induced cardiotoxicity. The authors present in brief, their own experience with multiple biomarkers in the detection of cardiotoxicity.
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17006104
- 003
- CZ-PrNML
- 005
- 20200211134804.0
- 007
- ta
- 008
- 170210s2014 xr f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.5507/bp.2014.004 $2 doi
- 035 __
- $a (PubMed)24457832
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Horáček, Jan $u Department of Internal Medicine, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic; 4th Department of Internal Medicine - Hematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove $7 xx0040415
- 245 10
- $a Biomarkers for the early detection of anthracycline-induced cardiotoxicity: current status / $c J. M. Horacek, M. Vasatova, R. Pudil, M. Tichy, P. Zak, M. Jakl, L. Jebavy, J. Maly
- 520 9_
- $a BACKGROUND: Cardiotoxicity is a well-known and potentially serious complication of anticancer therapy. Anthracycline-based chemotherapy represents the greatest risk. Early detection of cardiotoxicity is crucial for applying preventive and supportive therapeutic strategies. METHODS AND RESULTS: Various methods have been recommended for monitoring of cardiotoxicity. In our conditions, echocardiography and electrocardiography are routinely used. However, this approach shows low sensitivity for the early prediction of cardiomyopathy when the possibilities of appropriate management could still improve the patient's outcome. Recently, biomarkers of cardiac injury have been investigated in the assessment of chemotherapy-induced cardiotoxicity. Cardiospecific biomarkers, such as cardiac troponins, show high diagnostic efficacy in the early subclinical phase of the disease before the clinical onset of cardiomyopathy. Increase in their concentrations correlates with disease severity. As for natriuretic peptides, some studies, including ours, have shown promising results. Definitive evidence of their diagnostic and prognostic role in this context is still lacking and natriuretic peptides have not been routinely used for monitoring of cardiotoxicity in clinical practice. Other perspective biomarkers of cardiotoxicity in oncology are under study, especially heart-type fatty acid-binding protein (H-FABP) and glycogen phosphorylase BB (GPBB). Our studies using GPBB have provided encouraging results. However, the available data are limited and their practical use in this context cannot be recommended until their clinical efficacy is clearly defined. CONCLUSIONS: This review covers the current status of biomarkers for the early detection of anthracycline-induced cardiotoxicity. The authors present in brief, their own experience with multiple biomarkers in the detection of cardiotoxicity.
- 650 _2
- $a antracykliny $x škodlivé účinky $7 D018943
- 650 _2
- $a antibiotika antitumorózní $x škodlivé účinky $7 D000903
- 650 _2
- $a biologické markery $x analýza $7 D015415
- 650 _2
- $a kardiotoxicita $x diagnóza $x etiologie $7 D066126
- 650 _2
- $a lidé $7 D006801
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Vašatová, Martina $7 xx0135924 $u Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove
- 700 1_
- $a Pudil, Radek $7 xx0040409 $u 1st Department of Internal Medicine - Cardioangiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove
- 700 1_
- $a Tichý, Miloš, $d 1941- $7 xx0112487 $u Institute of Clinical Biochemistry and Diagnostics, University Hospital Hradec Kralove
- 700 1_
- $a Žák, Pavel, $d 1966- $7 mzk2006354145 $u 4th Department of Internal Medicine - Hematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove
- 700 1_
- $a Jakl, Martin $7 xx0135493 $u Department of Internal Medicine, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic; 1st Department of Internal Medicine - Cardioangiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove
- 700 1_
- $a Jebavý, Ladislav, $d 1950- $7 mzk2007408362 $u Department of Internal Medicine, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic; 4th Department of Internal Medicine - Hematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove
- 700 1_
- $a Malý, Jaroslav, $d 1946- $7 nlk19990073524 $u 4th Department of Internal Medicine - Hematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove
- 773 0_
- $w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czech Republic $x 1213-8118 $g Roč. 158, č. 4 (2014), s. 511-517
- 856 41
- $u http://biomed.papers.upol.cz/ $y domovská stránka časopisu
- 910 __
- $a ABA008 $b A 1502 $c 958 $y 4 $z 0
- 990 __
- $a 20170210 $b ABA008
- 991 __
- $a 20200211135158 $b ABA008
- 999 __
- $a ok $b bmc $g 1192291 $s 966751
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2014 $b 158 $c 4 $d 511-517 $e 20140123 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
- LZP __
- $b NLK118 $a Pubmed-20170210