• Something wrong with this record ?

Cystic and necrotic papillary renal cell carcinoma: prognosis, morphology, immunohistochemical, and molecular-genetic profile of 10 cases

K. Peckova, P. Martinek, K. Pivovarcikova, T. Vanecek, R. Alaghehbandan, K. Prochazkova, DP. Montiel, M. Hora, F. Skenderi, M. Ulamec, P. Rotterova, O. Daum, J. Ferda, W. Davidson, O. Ondic, M. Dubova, M. Michal, O. Hes,

. 2017 ; 26 (-) : 23-30. [pub] 20161020

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc17013325

Conflicting data have been published on the prognostic significance of tumor necrosis in papillary renal cell carcinoma (PRCC). Although the presence of necrosis is generally considered an adverse prognostic feature in PRCC, we report a cohort of 10 morphologically distinct cystic and extensively necrotic PRCC with favorable biological behavior. Ten cases of type 1 PRCC with a uniform morphologic pattern were selected from the 19 500 renal tumors, of which 1311 were PRCCs in our registry. We focused on precise morphologic diagnosis supported by immunohistochemical and molecular-genetic analysis. Patients included 8 men and 2 women with an age range of 32-85 years (mean, 62.6 years). Tumor size ranged from 6 to 14 cm (mean, 9.4 cm). Follow-up data were available in 7 patients, ranging from 0.5 to 14 years (mean, 4 years). All tumors were spherical, cystic, and circumscribed by a thick fibrous capsule, filled with hemorrhagic/necrotic contents. Limited viable neoplastic tissue was present only as a thin rim in the inner surface of the cyst wall, consistent with type 1 PRCC. All cases were positive for AMACR, OSCAR, CAM 5.2, HIF-2, and vimentin. Chromosome 7 and 17 polysomy was found in 5 of 9 analyzable cases, 2 cases demonstrated chromosome 7 and 17 disomy, and 1 case showed only chromosome 17 polysomy. Loss of chromosome Y was found in 5 cases, including 1 case with disomic chromosomes 7 and 17. No VHL gene abnormalities were found. Papillary renal cell carcinoma type 1 can present as a large hemorrhagic/necrotic unicystic lesion with a thick fibroleiomyomatous capsule. Most cases showed a chromosomal numerical aberration pattern characteristic of PRCC. All tumors followed a nonaggressive clinical course. Large liquefactive necrosis should not necessarily be considered an adverse prognostic feature, particularly in a subset of type 1 PRCC with unilocular cysts filled with necrotic/hemorrhagic material.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17013325
003      
CZ-PrNML
005      
20170418103328.0
007      
ta
008      
170413s2017 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.anndiagpath.2016.10.007 $2 doi
035    __
$a (PubMed)28038707
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Peckova, Kvetoslava $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
245    10
$a Cystic and necrotic papillary renal cell carcinoma: prognosis, morphology, immunohistochemical, and molecular-genetic profile of 10 cases / $c K. Peckova, P. Martinek, K. Pivovarcikova, T. Vanecek, R. Alaghehbandan, K. Prochazkova, DP. Montiel, M. Hora, F. Skenderi, M. Ulamec, P. Rotterova, O. Daum, J. Ferda, W. Davidson, O. Ondic, M. Dubova, M. Michal, O. Hes,
520    9_
$a Conflicting data have been published on the prognostic significance of tumor necrosis in papillary renal cell carcinoma (PRCC). Although the presence of necrosis is generally considered an adverse prognostic feature in PRCC, we report a cohort of 10 morphologically distinct cystic and extensively necrotic PRCC with favorable biological behavior. Ten cases of type 1 PRCC with a uniform morphologic pattern were selected from the 19 500 renal tumors, of which 1311 were PRCCs in our registry. We focused on precise morphologic diagnosis supported by immunohistochemical and molecular-genetic analysis. Patients included 8 men and 2 women with an age range of 32-85 years (mean, 62.6 years). Tumor size ranged from 6 to 14 cm (mean, 9.4 cm). Follow-up data were available in 7 patients, ranging from 0.5 to 14 years (mean, 4 years). All tumors were spherical, cystic, and circumscribed by a thick fibrous capsule, filled with hemorrhagic/necrotic contents. Limited viable neoplastic tissue was present only as a thin rim in the inner surface of the cyst wall, consistent with type 1 PRCC. All cases were positive for AMACR, OSCAR, CAM 5.2, HIF-2, and vimentin. Chromosome 7 and 17 polysomy was found in 5 of 9 analyzable cases, 2 cases demonstrated chromosome 7 and 17 disomy, and 1 case showed only chromosome 17 polysomy. Loss of chromosome Y was found in 5 cases, including 1 case with disomic chromosomes 7 and 17. No VHL gene abnormalities were found. Papillary renal cell carcinoma type 1 can present as a large hemorrhagic/necrotic unicystic lesion with a thick fibroleiomyomatous capsule. Most cases showed a chromosomal numerical aberration pattern characteristic of PRCC. All tumors followed a nonaggressive clinical course. Large liquefactive necrosis should not necessarily be considered an adverse prognostic feature, particularly in a subset of type 1 PRCC with unilocular cysts filled with necrotic/hemorrhagic material.
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a nádorové biomarkery $x analýza $7 D014408
650    _2
$a papilární karcinom $x diagnóza $x patologie $7 D002291
650    _2
$a karcinom z renálních buněk $x diagnóza $x patologie $7 D002292
650    _2
$a chromozomální aberace $7 D002869
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a imunohistochemie $x metody $7 D007150
650    _2
$a hybridizace in situ fluorescenční $x metody $7 D017404
650    _2
$a nádory ledvin $x diagnóza $x patologie $7 D007680
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a molekulární patologie $x metody $7 D057089
650    _2
$a prognóza $7 D011379
655    _2
$a časopisecké články $7 D016428
700    1_
$a Martinek, Petr $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Pivovarcikova, Kristyna $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Vanecek, Tomas $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Alaghehbandan, Reza $u Department of Pathology, University of British Columbia, Royal Columbian Hospital, Vancouver, Canada. $7 gn_A_00003232
700    1_
$a Prochazkova, Kristyna $u Department of Urology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Montiel, Delia Perez $u Department of Pathology, Instituto Nacional de Cancerologia, Mexico City, Mexico.
700    1_
$a Hora, Milan $u Department of Urology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Skenderi, Faruk $u Department of Pathology, University Clinical Center, Sarajevo, Bosnia and Herzegovina.
700    1_
$a Ulamec, Monika $u "Ljudevit Jurak" Pathology Department, Clinical Hospital Center "Sestre milosrdnice,", Zagreb, Croatia.
700    1_
$a Rotterova, Pavla $u Biopticka Laborator, Plzen, Czech Republic.
700    1_
$a Daum, Ondrej $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Ferda, Jiri $u Department of Radiodiology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Davidson, Whitney $u Department of Pathology, The University of Kansas School of Medicine, Kansas City, KS.
700    1_
$a Ondic, Ondrej $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Dubova, Magdalena $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Michal, Michal $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic.
700    1_
$a Hes, Ondrej $u Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Plzen, Czech Republic. Electronic address: hes@medima.cz.
773    0_
$w MED00166541 $t Annals of diagnostic pathology $x 1532-8198 $g Roč. 26, č. - (2017), s. 23-30
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28038707 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20170413 $b ABA008
991    __
$a 20170418103636 $b ABA008
999    __
$a ok $b bmc $g 1199790 $s 974103
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 26 $c - $d 23-30 $e 20161020 $i 1532-8198 $m Annals of diagnostic pathology $n Ann. diagn. pathol. $x MED00166541
LZP    __
$a Pubmed-20170413

Find record

Citation metrics

Archiving options