-
Je něco špatně v tomto záznamu ?
Testing for ROS1 in non-small cell lung cancer: a review with recommendations
L. Bubendorf, R. Büttner, F. Al-Dayel, M. Dietel, G. Elmberger, K. Kerr, F. López-Ríos, A. Marchetti, B. Öz, P. Pauwels, F. Penault-Llorca, G. Rossi, A. Ryška, E. Thunnissen,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 2003-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2003-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2003-01-01 do Před 1 rokem
- MeSH
- genová přestavba genetika MeSH
- lidé MeSH
- nádory plic diagnóza genetika metabolismus MeSH
- nemalobuněčný karcinom plic diagnóza genetika MeSH
- onkogeny genetika MeSH
- protoonkogenní proteiny genetika MeSH
- tyrosinkinasové receptory genetika MeSH
- tyrosinkinasy genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Rearrangements of the ROS1 gene occur in 1-2 % of non-small cell lung cancers (NSCLCs). Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the treatment of patients with advanced ROS1-positive NSCLC. Consequently, focus on ROS1 testing is growing. Most laboratories currently rely on fluorescence in situ hybridisation (FISH) assays using a dual-colour break-apart probe to detect ROS1 rearrangements. Given the rarity of these rearrangements in NSCLC, detection of elevated ROS1 protein levels by immunohistochemistry may provide cost-effective screening prior to confirmatory FISH testing. Non-in situ testing approaches also hold potential as stand-alone methods or complementary tests, including multiplex real-time PCR assays and next-generation sequencing (NGS) platforms which include commercial test kits covering a range of fusion genes. In order to ensure high-quality biomarker testing, appropriate tissue handling, adequate control materials and participation in external quality assessment programmes are essential, irrespective of the testing technique employed. ROS1 testing is often only considered after negative tests for EGFR mutation and ALK gene rearrangement, based on the assumption that these oncogenic driver events tend to be exclusive. However, as the use of ROS1 inhibitors becomes routine, accurate and timely detection of ROS1 gene rearrangements will be critical for the optimal treatment of patients with NSCLC. As NGS techniques are introduced into routine diagnostic practice, ROS1 fusion gene testing will be provided as part of the initial testing package.
Center of Predictive Molecular Medicine University Foundation Chieti Italy
Cerrahpasa Medical Faculty Istanbul University Istanbul Turkey
Department of Pathology Aberdeen University Medical School Aberdeen UK
Department of Pathology and Cytology Karolinska University Hospital Stockholm Sweden
Department of Pathology Centre Jean Perrin Clermont Ferrand France
Department of Pathology VU University Medical Centre Amsterdam The Netherlands
Institute of Pathology Charité Campus Mitte Berlin Germany
Institute of Pathology University Hospital Antwerp Edegem Belgium
Institute of Pathology University Hospital Basel Basel Switzerland
Institute of Pathology University Hospital Cologne and Network Genomic Medicine Cologne Germany
Laboratorio de Dianas Terapéuticas Hospital Universitario HM Sanchinarro C Oña 10 28050 Madrid Spain
Unit of Pathologic Anatomy Azienda USL Valle d'Aosta Aosta Italy
- 000
- 00000naa a2200000 a 4500
- 001
- bmc17013445
- 003
- CZ-PrNML
- 005
- 20180807105621.0
- 007
- ta
- 008
- 170413s2016 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00428-016-2000-3 $2 doi
- 035 __
- $a (PubMed)27535289
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Bubendorf, Lukas $u Institute of Pathology, University Hospital Basel, Basel, Switzerland.
- 245 10
- $a Testing for ROS1 in non-small cell lung cancer: a review with recommendations / $c L. Bubendorf, R. Büttner, F. Al-Dayel, M. Dietel, G. Elmberger, K. Kerr, F. López-Ríos, A. Marchetti, B. Öz, P. Pauwels, F. Penault-Llorca, G. Rossi, A. Ryška, E. Thunnissen,
- 520 9_
- $a Rearrangements of the ROS1 gene occur in 1-2 % of non-small cell lung cancers (NSCLCs). Crizotinib, a highly effective inhibitor of ROS1 kinase activity, is now FDA-approved for the treatment of patients with advanced ROS1-positive NSCLC. Consequently, focus on ROS1 testing is growing. Most laboratories currently rely on fluorescence in situ hybridisation (FISH) assays using a dual-colour break-apart probe to detect ROS1 rearrangements. Given the rarity of these rearrangements in NSCLC, detection of elevated ROS1 protein levels by immunohistochemistry may provide cost-effective screening prior to confirmatory FISH testing. Non-in situ testing approaches also hold potential as stand-alone methods or complementary tests, including multiplex real-time PCR assays and next-generation sequencing (NGS) platforms which include commercial test kits covering a range of fusion genes. In order to ensure high-quality biomarker testing, appropriate tissue handling, adequate control materials and participation in external quality assessment programmes are essential, irrespective of the testing technique employed. ROS1 testing is often only considered after negative tests for EGFR mutation and ALK gene rearrangement, based on the assumption that these oncogenic driver events tend to be exclusive. However, as the use of ROS1 inhibitors becomes routine, accurate and timely detection of ROS1 gene rearrangements will be critical for the optimal treatment of patients with NSCLC. As NGS techniques are introduced into routine diagnostic practice, ROS1 fusion gene testing will be provided as part of the initial testing package.
- 650 _2
- $a nemalobuněčný karcinom plic $x diagnóza $x genetika $7 D002289
- 650 _2
- $a genová přestavba $x genetika $7 D015321
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a nádory plic $x diagnóza $x genetika $x metabolismus $7 D008175
- 650 _2
- $a onkogeny $x genetika $7 D009857
- 650 _2
- $a tyrosinkinasy $x genetika $7 D011505
- 650 _2
- $a protoonkogenní proteiny $x genetika $7 D011518
- 650 _2
- $a tyrosinkinasové receptory $x genetika $7 D020794
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Büttner, Reinhard $u Institute of Pathology, University Hospital Cologne and Network Genomic Medicine, Cologne, Germany.
- 700 1_
- $a Al-Dayel, Fouad $u Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. $7 gn_A_00003638
- 700 1_
- $a Dietel, Manfred, $d 1948- $7 xx0226417 $u Institute of Pathology, Charité Campus Mitte, Berlin, Germany.
- 700 1_
- $a Elmberger, Göran $u Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.
- 700 1_
- $a Kerr, Keith $u Department of Pathology, Aberdeen University Medical School, Aberdeen, UK.
- 700 1_
- $a López-Ríos, Fernando $u Laboratorio de Dianas Terapéuticas, Hospital Universitario HM Sanchinarro, C/Oña, 10, 28050, Madrid, Spain. flopezrios@hmhospitales.com.
- 700 1_
- $a Marchetti, Antonio $u Center of Predictive Molecular Medicine, University-Foundation, Chieti, Italy.
- 700 1_
- $a Öz, Büge $u Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
- 700 1_
- $a Pauwels, Patrick $u Institute of Pathology, University Hospital Antwerp, Edegem, Belgium.
- 700 1_
- $a Penault-Llorca, Frédérique $u Department of Pathology, Centre Jean Perrin, Clermont-Ferrand, France.
- 700 1_
- $a Rossi, Giulio $u Unit of Pathologic Anatomy, Azienda USL Valle d'Aosta, Aosta, Italy.
- 700 1_
- $a Ryška, Aleš $u The Fingerland Department of Pathology, Charles University Faculty of Medicine and Faculty Hospital in Hradec Kralove, Hradec Kralove, Czech Republic.
- 700 1_
- $a Thunnissen, Erik $u Department of Pathology, VU University Medical Centre, Amsterdam, The Netherlands.
- 773 0_
- $w MED00004660 $t Virchows Archiv an international journal of pathology $x 1432-2307 $g Roč. 469, č. 5 (2016), s. 489-503
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/27535289 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20170413 $b ABA008
- 991 __
- $a 20180807105942 $b ABA008
- 999 __
- $a ok $b bmc $g 1199910 $s 974223
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2016 $b 469 $c 5 $d 489-503 $e 20160817 $i 1432-2307 $m Virchows Archiv $n Virchows Arch $x MED00004660
- LZP __
- $a Pubmed-20170413