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Effect of Porphyrin Sensitizer MgTPPS4 on Cytoskeletal System of HeLa Cell Line-Microscopic Study
J. Malohlava, K. Tomankova, L. Malina, J. Jiravova, A. Hanakova, K. Pizova, J. Zapletalova, H. Kolarova,
Cell biochemistry and biophysics.
2016 ;
74 (3) :
419-25.
[pub] 20160621
Language English Country United States
Document type Journal Article
Persistent link
https://www.medvik.cz/link/bmc17013756
Online
Full text
NLK
ProQuest Central
from 1997-10-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2011-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-10-01 to 1 year ago
- MeSH
- Cytoskeleton drug effects physiology radiation effects MeSH
- Photosensitizing Agents chemistry pharmacology MeSH
- HeLa Cells MeSH
- Microscopy, Confocal MeSH
- Humans MeSH
- Metalloporphyrins chemistry pharmacology MeSH
- Microscopy, Atomic Force MeSH
- Elastic Modulus MeSH
- Light MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Metalloporphyrins are an important group of sensitizers with a porphyrin skeleton. Their photophysical properties are significantly affected by the nature of the central ion. In this work, we focus on the mechanical properties of a cervix carcinoma cell line which underwent photodynamic treatment (PDT) with MgTPPS4 photosensitzer. Atomic force microscopy alongside confocal microscopy was used to quantify and qualify the structural characteristics before and after PDT. Cells before PDT showed a fine actin network and higher elasticity with the median of Young modulus 12.2 kPa. After PDT, the median of Young modulus was 13.4 kPa and a large redistribution in the actin network was observed.
References provided by Crossref.org
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