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Effect of Porphyrin Sensitizer MgTPPS4 on Cytoskeletal System of HeLa Cell Line-Microscopic Study
J. Malohlava, K. Tomankova, L. Malina, J. Jiravova, A. Hanakova, K. Pizova, J. Zapletalova, H. Kolarova,
Cell biochemistry and biophysics.
2016 ;
74 (3) :
419-25.
[pub] 20160621
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc17013756
Online
Plný text
NLK
ProQuest Central
od 1997-10-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-10-01 do Před 1 rokem
- MeSH
- cytoskelet účinky léků fyziologie účinky záření MeSH
- fotosenzibilizující látky chemie farmakologie MeSH
- HeLa buňky MeSH
- konfokální mikroskopie MeSH
- lidé MeSH
- metaloporfyriny chemie farmakologie MeSH
- mikroskopie atomárních sil MeSH
- modul pružnosti MeSH
- světlo MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Metalloporphyrins are an important group of sensitizers with a porphyrin skeleton. Their photophysical properties are significantly affected by the nature of the central ion. In this work, we focus on the mechanical properties of a cervix carcinoma cell line which underwent photodynamic treatment (PDT) with MgTPPS4 photosensitzer. Atomic force microscopy alongside confocal microscopy was used to quantify and qualify the structural characteristics before and after PDT. Cells before PDT showed a fine actin network and higher elasticity with the median of Young modulus 12.2 kPa. After PDT, the median of Young modulus was 13.4 kPa and a large redistribution in the actin network was observed.
Citace poskytuje Crossref.org
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- $a Malohlava, Jakub $u Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 3, 77515, Olomouc, Czech Republic. jakub.malohlava@upol.cz. Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hnevotinska 5, 77515, Olomouc, Czech Republic. jakub.malohlava@upol.cz.
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