Skin toxicity is the most important side effect of cetuximab administration, but little is known about the eye toxicity, including periorbital skin. We present here four cases of patients with metastatic colorectal carcinoma treated with the combination of cetuximab, irinotecan, 5-fluorouracil and leucovorin who had manifestation of complications in the eye or periorbital skin. These manifestations consisted of erythematous eruptions in the periorbital skin with blepharitis and conjunctivitis in three patients and trichomegaly in one patient. The symptoms were controlled with local therapy including corticosteroids and antibiotics. The skin toxicity in the periorbital region is more important than in other skin areas because of the impact on the social activity of the patient and the vision. The manifestations of eye toxicity of cetuximab may be controlled by local therapy, and the management of these patients requires the collaboration of medical oncologist and ophthalmologist.

Department of Medicine Charles University Medical School and Teaching Hospital Hradec Králové Czech Republic

Citace poskytuje Crossref.org

Neopterin as a biomarker of immune response in cancer patients

Risk factors of atherosclerosis during systemic therapy targeting vascular endothelial growth factor

FOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy