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Effects of novel maleimide derivatives on cell cultures with different properties

G. Ostrovska, O. Maslova, D. Delev, R. Opatrilova, P. Kuzliak, N. Savytska,

. 2016 ; 17 (3) : 505-15. [pub] 20160430

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17013888
E-zdroje Online Plný text

NLK ProQuest Central od 2000-01-01 do 2017-12-31
Medline Complete (EBSCOhost) od 2011-02-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest) od 2000-01-01 do 2017-12-31
Health & Medicine (ProQuest) od 2000-01-01 do 2017-12-31

Odkazy

PubMed 27139892
DOI 10.1007/s10561-016-9558-5
Knihovny.cz E-zdroje

The paper is focused on pilot study of effects of novel synthetic protein kinase inhibitors-maleimide derivatives in different concentrations on normal, transformed and multipotent cell lines. Influence on cell proliferation and morphological characteristics has been demonstrated. The chosen agents cause antiproliferative effect on transformed cells and are not cytotoxic to normal cell lines. Moreover, different maleimide derivatives' effects on multipotent cells in attached and floating states has been shown. Described results can be used for further research of the maleimide derivatives as antitumor agents.

Citace poskytuje Crossref.org

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$a Maslova, Olga $u Taras Shevchenko National University of Kyiv, Kiev, Ukraine. Hemafund Ltd., Kiev, Ukraine.
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$a Delev, Delian $u Department Pharmacology and Clinical Pharmacology, Medical Faculty, Medical University of Plovdiv, Plovdiv, Bulgaria.
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